(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER
- Product Name
- (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER
- CAS No.
- 377780-72-8
- Chemical Name
- (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER
- Synonyms
- 2-[2-(Bromomethyl)phenyl]-4,4,5,5-tetra;(2-BROMOMETHYLPHENYL)BORONIC ACID, PICOL ESTER;(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER;2-(BROMOMETHYL)BENZENEBORONIC ACID PINACOL ESTER;2-(Bromomethyl)benzeneboronicacidpinacolcyclicester;2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide;2-(2-(Bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1,3,2-Dioxaborolane, 2-[2-(bromomethyl)phenyl]-4,4,5,5-tetramethyl-;2-[2-(Bromomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl bromide
- CBNumber
- CB7134151
- Molecular Formula
- C13H18BBrO2
- Formula Weight
- 297
- MOL File
- 377780-72-8.mol
(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER Property
- Melting point:
- 78-80°C
- Boiling point:
- 360.6±25.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Sparingly)
- form
- solid
- color
- white to off-white
- CAS DataBase Reference
- 377780-72-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 2
- Hazard Note
- Irritant/Keep Cold
- TSCA
- No
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 716235
- Product name
- 2-Bromomethylphenylboronic acid pinacol ester
- Purity
- 95%
- Packaging
- 1g
- Price
- $180
- Updated
- 2025/07/31
- Product number
- T3393
- Product name
- 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $122
- Updated
- 2025/07/31
- Product number
- T3393
- Product name
- 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $360
- Updated
- 2025/07/31
- Product number
- B683635
- Product name
- 2-Bromomethylphenylboronic acid pinacol ester
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- B683635
- Product name
- 2-Bromomethylphenylboronic acid pinacol ester
- Packaging
- 2.5g
- Price
- $155
- Updated
- 2021/12/16
(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER Chemical Properties,Usage,Production
Uses
2-Bromomethylphenylboronic Acid Pinacol Ester is an intermediate used to prepare [(fluorophenylcarbamoyl)pyridinylsulfanylmethyl]phenylboronic acid and noncompetitive boronic acid antagonist of CXCR1 and CXCR2.
Synthesis
76-09-5
16419-60-6
377780-72-8
To a three-neck flask equipped with a Dean-Stark splitter was added 30 mL of toluene followed by 2-methylphenylboronic acid (0.21 g, 1.55 mmol) and pinacol (0.22 g, 1.86 mmol). The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the mixture was washed three times with 30 mL of water to remove unreacted pinacol and phenylboronic acid. The organic phase was separated and the toluene solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was dissolved in 50 mL of dichloromethane and washed again with 30 mL of water. Anhydrous sodium sulfate was added to the organic phase to dry, and the dried solution was evaporated under reduced pressure to give 0.32 g of crude product. The resulting crude product (0.32 g, 1.47 mmol), N-bromosuccinimide (NBS, 0.39 g, 2.2 mmol) and azobisisobutyronitrile (AIBN, 0.003 g, 0.018 mmol) were dissolved in 10 mL of acetonitrile. The reaction solution was refluxed at 90 °C for 2 hours. After the reaction was completed, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography using petroleum ether (60~90 °C)/ethyl acetate (v/v = 1:1) as eluent to obtain the target product 2-bromoethylphenylboronic acid pinacol ester as white solid (0.53 g, 80% yield).
References
[1] Patent: CN107383078, 2017, A. Location in patent: Paragraph 0058; 0063; 0064; 0065; 0066; 0067; 0068
(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER Suppliers
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- --
- Fax
- --
- brian@chordip.com
- Country
- Jordan
- ProdList
- 704
- Advantage
- 51
View Lastest Price from (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER manufacturers
- Product
- (2-Bromomethylphenyl)boronic acid pinacol ester 377780-72-8
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-07-03
- Product
- (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER 377780-72-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER 377780-72-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09