(4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE
- Product Name
- (4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE
- CAS No.
- 86286-50-2
- Chemical Name
- (4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE
- Synonyms
- 4,5-diphenyl-2-oxazolidinone;(4R,5S)-4,5-DIPHENYLOXAZOLIDIN-2-ONE;(4R,5S)-4,5-Diphenyl-2-oxazolidinone;2-Oxazolidinone, 4,5-diphenyl-, (4R,5S)-;(4R,5S)-cis-4,5-Diphenyloxazolidin-2-one;(4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE;(4R,5S)-4,5-Diphenyl-2-oxazolidinone,99%e.e.;(4R,5S)-(+)-cis-4,5-Diphenyl-2-oxazolidinone, ee: 98%;(4R,5S)-(+)-cis-4,5-Diphenyl-2-oxazolidinone, 98%, ee: 98%
- CBNumber
- CB1717996
- Molecular Formula
- C15H13NO2
- Formula Weight
- 239.27
- MOL File
- 86286-50-2.mol
(4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE Property
- Melting point:
- 227-230 °C (lit.)
- Boiling point:
- 466.6±45.0 °C(Predicted)
- Density
- 1.192±0.06 g/cm3(Predicted)
- pka
- 11.56±0.60(Predicted)
- optical activity
- [α]20/D 57±4°, c = 2 in methanol
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 454540
- Product name
- (4R,5S)-(+)-cis-4,5-Diphenyl-2-oxazolidinone
- Purity
- 98%
- Packaging
- 1g
- Price
- $230
- Updated
- 2023/01/07
- Product number
- CHM0004668
- Product name
- (4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $744.02
- Updated
- 2021/12/16
- Product number
- CM190719
- Product name
- (4R,5S)-4,5-diphenyloxazolidin-2-one
- Purity
- 95%
- Packaging
- 5g
- Price
- $408
- Updated
- 2021/12/16
- Product number
- CD11042084
- Product name
- (4R,5S)-cis-4,5-Diphenyloxazolidin-2-one
- Purity
- 95+%
- Packaging
- 5g
- Price
- $432
- Updated
- 2021/12/16
- Product number
- A253448
- Product name
- (4R,5S)-cis-4,5-Diphenyloxazolidin-2-one
- Purity
- 95+%
- Packaging
- 5g
- Price
- $518
- Updated
- 2021/12/16
(4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE Chemical Properties,Usage,Production
Chemical Properties
White powder or crystal
Uses
Versatile chiral auxiliary for asymmetric synthesis. For a recent review, see Aldrichimica Acta .
Preparation
To a stirred suspension of commercially available (10.0 g, 47 mmol) and triethylamine (14.4 mL, 0.10 mol) in dichloromethane (100 mL), diphosgene (3.0 mL, 25 mmol) was added dropwise at 0 °C and the mixture was stirred for 1 h at the same temperature. After concentration in vacuo, the residue was poured into water to precipitate crystals. The crystals were collected by filtration, successively washed with 10% HCl and H2O, and dried in vacuo at 50–60 °C for 3 h to afford 593a as colorless crystals (10.9 g, 97%).