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ATPA

Product Name
ATPA
CAS No.
140158-50-5
Chemical Name
ATPA
Synonyms
ATPA;(R,S)-ATPA;ATP synthase α chain;alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate;(RS)-A-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(R,S)-ALPHA-AMINO-3-HYDROXY-5-T-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(RS)-ALPHA-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(RS)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOXAZOL-4-YL)PROPANOIC ACID;2-Amino-3-(5-(tert-butyl)-3-oxo-2,3-dihydroisoxazol-4-yl)propanoic acid;4-Isoxazolepropanoic acid, α-amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-
CBNumber
CB1719521
Molecular Formula
C10H16N2O4
Formula Weight
228.25
MOL File
140158-50-5.mol
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ATPA Property

Density 
1.263±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at +4°C
solubility 
DMSO: 10 mg/mL
form 
solid
pka
2.15±0.10(Predicted)
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1107
Product name
ATPA
Purity
≥98%(HPLC)
Packaging
10
Price
$227
Updated
2021/12/16
Tocris
Product number
1107
Product name
ATPA
Purity
≥98%(HPLC)
Packaging
50
Price
$936
Updated
2021/12/16
Usbiological
Product number
254690
Product name
ATPA
Packaging
10mg
Price
$480
Updated
2021/12/16
TRC
Product number
A790535
Product name
(R,S)-ATPA
Packaging
1mg
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-0021056
Product name
ATPA
Purity
>98.0%
Packaging
10mg
Price
$685
Updated
2021/12/16
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ATPA Chemical Properties,Usage,Production

Uses

(R,S)-ATPA is a selective and potent GluR5 kainate receptor agonist (1,2). It inhibits GluK2 kainate receptor-JNK3 protein pathway by activating GABA type A receptor in rat after cerebral ischemia-reperfusion injury (3). (R,S)-ATPA is a neuroprotective agent.

Definition

ChEBI: 2-amino-3-(5-tert-butyl-3-oxo-4-isoxazolyl)propanoic acid is an alpha-amino acid.

Biological Activity

A selective and potent GluR5 kainate receptor agonist (K i = 4.3 nM), inactive at GluR6 (K i > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (K i values of 6 - 14 μ M). Also available as part of the Kainate Receptor Tocriset™ .

storage

Desiccate at +4°C

ATPA Preparation Products And Raw materials

Raw materials

Preparation Products

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ATPA Suppliers

China 13 Germany 1 Switzerland 3 United Kingdom 1 United States 13 Global 31
EMMX Biotechnology LLC
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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32063
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TargetMol Chemicals Inc.
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+8613564774135
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zijue.cai@tsbiochem.com
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United States
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TargetMol Chemicals Inc.
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support@targetmol.com
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United States
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38463
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Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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United States
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52925
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ApexBio Technology
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MedChemExpress
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3B Scientific Corporation
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Riedel-de Haen AG
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3B Scientific Corporation
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HONEST JOY HOLDINGS LIMITED
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American Radiolabeled Chemicals, Inc.
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Spectrum Chemicals & Laboratory Products
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140158-50-5, ATPARelated Search:

ATPA ( Z )-2-(2-AMINOTHIAZOL-4-YL)-2-PENTENOIC ACID (ATPA) ATPA ((RS)-2-AMINO-3-(3-HYDROXY-5-TERT-B,(R,S)-ATPA,ATPA (R)-ATPA, >97% (RS)-AMPA CHEMBRDG-BB 4009738 (R,S)-2-AMINO-3-[5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL]PROPIONIC ACID 2-ISOXAZOL-4-YL-ETHYLAMINE ATPA (R)-ATPA (S)-ATPA

  • (R,S)-ATPA
  • (RS)-A-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID
  • (R,S)-ALPHA-AMINO-3-HYDROXY-5-T-BUTYL-4-ISOXAZOLEPROPIONIC ACID
  • (RS)-ALPHA-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID
  • (RS)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOXAZOL-4-YL)PROPANOIC ACID
  • ATPA
  • alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate
  • ATP synthase α chain
  • 4-Isoxazolepropanoic acid, α-amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-
  • 2-Amino-3-(5-(tert-butyl)-3-oxo-2,3-dihydroisoxazol-4-yl)propanoic acid
  • 4-Isoxazolepropanoic acid, α-amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-
  • 140158-50-5
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Ligand-Gated Ion Channels
  • Ion Channels
  • Ionotropic Glutamate Receptor Modulators