ChemicalBook > CAS DataBase List > AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER

AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER

Product Name
AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER
CAS No.
148451-96-1
Chemical Name
AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER
Synonyms
L732138;L-732,138;L-732138, 10 mM in DMSO;AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER;N-acetyl-L-tryptophan 3,5-bis*(trifluoromethyl)be;3,5-bis(trifluoromethyl)benzyl N-acetyltryptophan;N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROM ETHYL)BENZ;3,5-Bis(trifluoromethyl)benzyl acetyl-L-tryptophanate;N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROMETHYL)-BENZYL ESTER;N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester,L-732,138
CBNumber
CB1721780
Molecular Formula
C22H18F6N2O3
Formula Weight
472.38
MOL File
148451-96-1.mol
More
Less

AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER Property

Melting point:
147-148 °C(lit.)
Boiling point:
554.1±50.0 °C(Predicted)
Density 
1.396±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble to 100 mM in ethanol and to 100 mM in DMSO
pka
14.63±0.46(Predicted)
form 
powder
color 
White to off-white
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Tocris
Product number
0868
Product name
L-732,138
Purity
≥98%(HPLC)
Packaging
10
Price
$95
Updated
2021/12/16
Tocris
Product number
0868
Product name
L-732,138
Purity
≥98%(HPLC)
Packaging
50
Price
$382
Updated
2021/12/16
TRC
Product number
L730980
Product name
L-732,138
Packaging
100mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB100988
Product name
[3,5-Bis(Trifluoromethyl)phenyl]methyl (2S)-2-acetamido-3-(1H-Indol-3-Yl)propanoate
Packaging
10mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0021036
Product name
L-732138
Purity
99.43%
Packaging
5mg
Price
$230
Updated
2021/12/16
More
Less

AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER Chemical Properties,Usage,Production

Uses

L-732,138 is a Substance P (SP) receptor antagonist.

Biological Activity

Potent and highly selective competitive tachykinin NK 1 receptor antagonist (IC 50 = 2.3 nM).

in vivo

L-732138 (10-4-10-2 mol/kg; intravenous injection; for 15 minutes; male Dunkin-Hartley guinea-pigs) treatment abolishes vagally-induced plasma exudation and significantly inhibits the enhancement by LPS. The LPS-enhanced vagally-induced plasma exudation is not completely inhibited by either L-732138 or SOD pretreatment alone, but is blocked by the combination of both pretreatments[3].

Animal Model:Male Dunkin-Hartley guinea-pigs (350-500 g) injected with lipopolysaccharide (LPS)[3]
Dosage:10-4 mol/kg , 10-3 mol/kg and 10-2 mol/kg
Administration:Intravenous injection; for 15 minutes
Result:Abolished the vagally-induced plasma leakage in tracheobronchial tissues, and dose-dependently inhibited the LPS enhanced vagally-induced plasma exudation in traceobronchial tissues.

IC 50

NK1: 2.3 nM (IC50)

storage

Store at RT

AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER Suppliers

China 50 Germany 1 Switzerland 2 United Kingdom 3 United States 11 Global 67
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
Aikon International Limited
Tel
025-58851090 15955137747
Fax
(6)02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15949
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
9987
Advantage
58

148451-96-1, AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTERRelated Search:

N-Acetyl-L-tryptophan AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER 3,5-Bis(trifluoromethyl)benzyl alcohol L-TRYPTOPHAN BENZYL ESTER 98 AC-TRP-OME AC-TRP-OET

  • N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROMETHYL)-BENZYL ESTER
  • L-732,138
  • AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER
  • N-acetyl-L-tryptophan 3,5-bis*(trifluoromethyl)be
  • L732138
  • N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROM ETHYL)BENZ
  • 3,5-bis(trifluoromethyl)benzyl N-acetyltryptophan
  • N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester,L-732,138
  • [3,5-Bis(Trifluoromethyl)phenyl]methyl (2S)-2-acetamido-3-(1H-Indol-3-Yl)propanoate
  • L-Tryptophan, N-acetyl-, [3,5-bis(trifluoromethyl)phenyl]methyl ester
  • N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester >=99% (TLC), powder
  • 3,5-Bis(trifluoromethyl)benzyl acetyl-L-tryptophanate
  • cytotoxicity,vagally-induced,NK receptor,Neurokinin Receptor,Inhibitor,ntravenously,lipopolysaccharide,plasma,Tachykinin receptor,stimulation,L732138,mitogen,peralgesia,inhibit,L-732138,Antitumorhy,apoptotic,L 732138
  • L-732138, 10 mM in DMSO
  • 148451-96-1
  • C22H18F6N2O3
  • Amino Acids and Peptides
  • BioChemical
  • Biochemicals and Reagents
  • Antagonist
  • Tachykinins
  • Peptides