PGP-4008

Product Name: PGP-4008
CAS No.: 365565-02-2
Chemical Name: PGP-4008
Synonyms: Abcb1b;PGP-4408;PGP-4008;Mdr1b Rat;PGP4008,PGP 4008;Mdr1b Rat Vesicular Transport Kit;PGP 4008, P-glycoprotein inhibitor;rodent multidrug resistance protein;Recombinant Human p-Glycoprotein/MRP;N-(1-BENZYL-2,3-DIHYDRO-1H-PYRROLO[2,3-B]QUINOLIN-4-YL)-2-PHENYLACETAMIDE
CBNumber: CB1722686
Molecular Formula: C26H23N3O
Formula Weight: 393.48
MOL File: Mol file

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PGP-4008 Property

storage temp.: −20°C
solubility: DMSO: 50mM; Ethanol: 5mM
form: White to off-white powder.
color: White to off-white

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Safety

Hazard Codes: T
Risk Statements: 45-21/22-34-37-52/53
Safety Statements: 22-24/25-61-45-36/37/39-26-53
WGK Germany: 3
HS Code: 3504009000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P6490
Product name: PGP-4008
Packaging: 2MG
Price: $378
Updated: 2022/05/15

Cayman Chemical

Product number: 20901
Product name: PGP-4008
Purity: ≥95%
Packaging: 500μg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 20901
Product name: PGP-4008
Purity: ≥95%
Packaging: 1mg
Price: $90
Updated: 2024/03/01

AK Scientific

Product number: 3358CR
Product name: N-(1-Benzyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl)-2-phenylacetamide
Packaging: 1mg
Price: $198
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0001016
Product name: PGP-4008
Purity: 95.00%
Packaging: 2MG
Price: $238
Updated: 2021/12/16

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PGP-4008 Chemical Properties,Usage,Production

Description

PGP-4008 is a selective inhibitor of P-glycoprotein (P-gp) that does not affect the activity of multidrug resistance-related protein 1 (MRP1). It is effective in vitro and, when delivered intraperitoneally, in vivo, inhibiting tumor growth when given with doxorubicin . PGP-4008 also enhances the ability of docetaxel to inhibit growth and drive apoptosis in ovarian cancer cells.

Uses

PGP-4008 is a specific P-glycoprotein (Pgp) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin[1].

References

[1] Brian D Lee, et al. Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11;47(6):1413-22. DOI:10.1021/jm0303204

PGP-4008 Preparation Products And Raw materials

Raw materials

Preparation Products

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PGP-4008 Suppliers

China 42 Switzerland 2 United Kingdom 4 United States 8 Global 56

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 18100677375
Email: sales@szzxbio.com
Country: China
ProdList: 2993
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

ZSGB-BIO

Tel: 02-400-810-9781 400810978
Email: sales@zsbio.com
Country: China
ProdList: 2887
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

365565-02-2, PGP-4008Related Search:

2-Phenylacetamide

Recombinant Human p-Glycoprotein/MRP

PGP-4008

PGP-4408

N-(1-BENZYL-2,3-DIHYDRO-1H-PYRROLO[2,3-B]QUINOLIN-4-YL)-2-PHENYLACETAMIDE

Abcb1b

Mdr1b Rat

rodent multidrug resistance protein

Benzeneacetamide, N-[2,3-dihydro-1-(phenylmethyl)-1H-pyrrolo[2,3-b]quinolin-4-yl]-

PGP4008,PGP 4008

PGP 4008, P-glycoprotein inhibitor

Mdr1b Rat Vesicular Transport Kit

365565-02-2

Enzyme Inhibitors

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

P-Glycoprotein

P to Q

BioChemical

Biochemicals and Reagents

proteins