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4-Ethoxyphenylboronic acid

Product Name
4-Ethoxyphenylboronic acid
CAS No.
22237-13-4
Chemical Name
4-Ethoxyphenylboronic acid
Synonyms
AKOS BRN-0070;4-Boronophenetole;RARECHEM AH PB 0138;4-Ethoxyphenylboroni;4-Etoxyphenylboronic acid;P-ETHOXYPHENYLBORONIC ACID;4-ETHOXYPHENYLBORONIC ACID;(4-ethoxyphenyl)boronicaci;4-ETHOXYBENZENEBORONIC ACID;4-Ethoxybenzeneboronicacid,96%
CBNumber
CB1724741
Molecular Formula
C8H11BO3
Formula Weight
165.98
MOL File
22237-13-4.mol
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4-Ethoxyphenylboronic acid Property

Melting point:
121-128 °C(lit.)
Boiling point:
317.6±44.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
8.98±0.10(Predicted)
form 
solid
color 
White to Light yellow
BRN 
3530408
InChI
InChI=1S/C8H11BO3/c1-2-12-8-5-3-7(4-6-8)9(10)11/h3-6,10-11H,2H2,1H3
InChIKey
WRQNDLDUNQMTCL-UHFFFAOYSA-N
SMILES
B(C1=CC=C(OCC)C=C1)(O)O
CAS DataBase Reference
22237-13-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-22
Safety Statements 
37/39-26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29163990
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
455539
Product name
4-Ethoxyphenylboronic acid
Packaging
1g
Price
$32.4
Updated
2023/01/07
Sigma-Aldrich
Product number
455539
Product name
4-Ethoxyphenylboronic acid
Packaging
10g
Price
$106
Updated
2023/01/07
TCI Chemical
Product number
E0725
Product name
4-Ethoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
E0725
Product name
4-Ethoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$59
Updated
2025/07/31
TRC
Product number
E892828
Product name
4-Ethoxyphenylboronic acid
Packaging
2.5g
Price
$65
Updated
2021/12/16
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4-Ethoxyphenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

4-Methoxybenzeneboronic acid is used for suzuki reaction.

Application

Reactant involved in Suzuki cross coupling reactions
Reactant involved in the synthesis of biologically active molecules including:
Novel modulators of survival motor neuron protein for treatment of spinal muscular atrophy
Amino-trimethoxyphenyl-aryl thiazoles for use as microtubule inhibitors and antitumor agents
Bicyclic hydroxyphenyl methanone derivatives for use as hydroxysteroid dehydrogenase inhibitors
Dual immunosuppressive and anti-inflammatory agents
Antiproliferatives via Suzuki cross-coupling / amination reactions

Synthesis

A hexane solution of butyllithium (30 mL, 1.58 M, 47 mmol) was added dropwise to a THF solution (50 mL) of 2-bromo-??,??-trifluorotoluene (9.79 g, 43.5 mmol) at -78?? C. The aryllithium was then transferred to a THF solution of B(OEt)3 (30 mL, 176 mmol) by cannulae. After stirring at this temperature for 3 hours, the resulting aryl lithium was transferred via cannula to a THF solution (100 mL) of triethyl borate (B(OEt)3, 30 mL, 176 mmol) (aryl lithium may be unstable at higher temperatures. We recommend making the transfer as soon as possible). Warm the reaction mixture to room temperature and stir overnight. Hydrochloric acid (2M, 80 mL) was added and the mixture was extracted with ethyl acetate. The combined organic layers were dried with anhydrous sodium sulfate and then evaporated under vacuum. The desired boric acid was dissolved in hot toluene and separated from the toluene-insoluble residue. The combined toluene solutions were evaporated and the remaining solid was recrystallized from toluene to give 4-ethoxyphenylboronic acid in 6.02 g, 73% yield. Yield 16%.

4-Ethoxyphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Ethoxyphenylboronic acid Suppliers

Americas 1 Belgium 3 China 175 Europe 3 France 3 Germany 13 India 13 Italy 1 Japan 4 Jordan 1 Russia 1 Switzerland 2 United Kingdom 13 United States 54 Global 287
Tianjin Xinshengjiahe Technology Development Co., Ltd.
Tel
022-83719186 13212251377
Fax
086-022-8789 9925
Email
18522618860@163.com
Country
China
ProdList
79
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55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
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66
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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81
Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
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44802
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
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66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
11777
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60
Shanghai Scientia Pharmaceutical Technology Co., Ltd.
Tel
21-21-54301573 13917723525
Fax
(86)21-51861981
Email
sales@scientiapharm.com
Country
China
ProdList
263
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View Lastest Price from 4-Ethoxyphenylboronic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
4-ETHOXYPHENYLBORONIC ACID 22237-13-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-ETHOXYPHENYLBORONIC ACID 22237-13-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
4-ETHOXYPHENYLBORONIC ACID 22237-13-4
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2018-12-17

22237-13-4, 4-Ethoxyphenylboronic acidRelated Search:

2-CHLORO-4-ETHOXYPHENYLBORONIC ACID (4-CHLORO-2-ETHOXYPHENYL)BORONIC ACID 5-CHLORO-2-ETHOXYPHENYLBORONIC ACID 3,5-DIMETHYL-4-ETHOXYPHENYLBORONIC ACID 3-CHLORO-4-ETHOXYPHENYLBORONIC ACID 2,3-Difluoro-4-ethoxyphenylboronic acid 6-Bromo-2-chloro-3-ethoxyphenylboronic acid 2,6-Difluoro-3-ethoxybenzeneboronic acid 2,5-Dimethyl-4-ethoxyphenylboronic acid 2-Bromo-6-ethoxyphenylboronic acid 3-Ethoxyphenylboronic Acid (contains varying amounts of Anhydride),3-Ethoxyphenylboronic acid ,98%,3-ETHOXYPHENYLBORONIC ACID,M-ETHOXYPHENYLBORONIC ACID 2-ETHOXYPHENYLBORONIC ACID,2-Ethoxyphenylboronic Acid (contains varying amounts of Anhydride) 2,3-Difluoro-6-ethoxyphenylboronic acid 5-Fluoro-2-(trifluoroethoxy)phenylboronicacid Phenylboronic acid 3-BROMO-2-ETHOXYPHENYLBORONIC ACID 2,6-DIFLUORO-3-ETHOXYPHENYLBORONIC ACID 5-FORMYL-2-ETHOXYPHENYLBORONIC ACID

  • 4-Boronophenetole
  • Boronicacid, B-(4-ethoxyphenyl)-
  • 4-ETHOXYPHENYLBORONIC ACID
  • 4-ETHOXYBENZENEBORONIC ACID
  • AKOS BRN-0070
  • RARECHEM AH PB 0138
  • P-ETHOXYPHENYLBORONIC ACID
  • 4-Ethoxybenzeneboronicacid,96%
  • 4-Ethoxyphenylboronic Acid (contains varying amounts of Anhydride)
  • 4-Ethoxyphenylboronic acid ,98%
  • 4-Etoxyphenylboronic acid
  • 4-Ethoxyphenylboroni
  • 4-Ethoxyphenylboronic acid, May contain varying amounts of anhydride, 97%
  • 4-Ethoxyphenylboronic acid, 97%, May contain varying aMounts of anhydride
  • (4-n-Ethoxyphenyl)boronic acid
  • (4-ethoxyphenyl)boronicaci
  • 4-Ethoxyphenylboronic acid - [E3100]
  • 22237-13-4
  • Organometallic Reagents
  • BORONIC ACID
  • Aryl
  • Boronic Acids and Derivatives
  • Boronic Acids
  • Boronate Ester
  • Potassium Trifluoroborate
  • Boronic Acid
  • B (Classes of Boron Compounds)
  • Boronic Acids
  • Boronic Acids
  • Boronic Acids and Derivatives
  • Alkoxy
  • Aryl
  • Organoborons
  • blocks
  • BoronicAcids