2,3-Difluoro-4-ethoxybenzeneboronic acid
- Product Name
- 2,3-Difluoro-4-ethoxybenzeneboronic acid
- CAS No.
- 212386-71-5
- Chemical Name
- 2,3-Difluoro-4-ethoxybenzeneboronic acid
- Synonyms
- 4-Ethoxy-2,3-difluorophenyl;4-Ethoxy-2,3-difluorphenylboronic acid;4-Ethoxy-2,3-difluorophenylboronic acid;2,3-Difluoro-4-ethoxyphenylboronic acid;2,3-Difluror-4-ethoxyphenylboronic acid;(4-ethoxy-2,3-difluorophenyl)boronicaci;2,3-Difluoro-4-ethoxybenzeneboronic acid;4-Ethoxy-2,3-difluorobenzeneboronic Acid;2,3-Difluoro-4-ethoxybenzeneboronicacid98%;B-(4-Ethoxy-2,3-difluorophenyl)boronic acid
- CBNumber
- CB7958102
- Molecular Formula
- C8H9BF2O3
- Formula Weight
- 201.96
- MOL File
- 212386-71-5.mol
2,3-Difluoro-4-ethoxybenzeneboronic acid Property
- Melting point:
- 151-154
- Boiling point:
- 316.0±52.0 °C(Predicted)
- Density
- 1.29
- vapor pressure
- 0.002Pa at 25℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- Solid
- pka
- 7.69±0.58(Predicted)
- color
- White to Almost white
- Water Solubility
- 145mg/L at 20℃
- InChI
- InChI=1S/C8H9BF2O3/c1-2-14-6-4-3-5(9(12)13)7(10)8(6)11/h3-4,12-13H,2H2,1H3
- InChIKey
- OBKSFBWOZSQGGC-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(OCC)C(F)=C1F)(O)O
- LogP
- 2.3 at 23℃
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- E1192
- Product name
- 4-Ethoxy-2,3-difluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- E1192
- Product name
- 4-Ethoxy-2,3-difluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $96
- Updated
- 2025/07/31
- Product number
- D473338
- Product name
- 2,3-Difluoro-4-ethoxyphenylboronicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- D473338
- Product name
- 2,3-Difluoro-4-ethoxyphenylboronicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 035291
- Product name
- 2,3-Difluoro-4-ethoxyphenylboronic acid
- Packaging
- 5g
- Price
- $79
- Updated
- 2021/12/16
2,3-Difluoro-4-ethoxybenzeneboronic acid Chemical Properties,Usage,Production
Chemical Properties
off-white powder
Uses
suzuki reaction
Flammability and Explosibility
Not classified
Synthesis
156573-09-0
121-43-7
212386-71-5
General procedure for the synthesis of 2,3-difluoro-4-bromophenyl ethyl ether and trimethyl borate as raw materials for the synthesis of 2,3-difluoro-4-ethoxyphenylboronic acid: intermediate compound T-2 (129.5 g) obtained in Example 1 was dissolved in dry tetrahydrofuran (Dry THF, 500 ml) and the resulting solution was cooled to -70 °C. Under nitrogen protection, n-butyllithium (n-BuLi, 500 ml) was slowly added dropwise and the reaction was stirred at -70 °C for 2 hours. Subsequently, a dry tetrahydrofuran (Dry THF) solution of trimethyl borate (129.5 g) was added slowly dropwise at the same temperature. Upon completion of the reaction, the reaction solution was warmed to room temperature and stirring was continued for 16 hours. The reaction mixture was acidified by adding 2N hydrochloric acid (200 ml) to the reaction mixture and subsequently extracted with toluene. The organic layer was washed sequentially with water and saturated aqueous sodium chloride solution and then dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give a light brown solid. Purification by recrystallization (heptane: toluene = 4:1, v/v) resulted in colorless crystals T-20 (117.2 g, yield: 71%).
References
[1] Patent: EP2484658, 2012, A1. Location in patent: Page/Page column 42
[2] Patent: JP5663957, 2015, B2. Location in patent: Paragraph 0137-0138; 0140
[3] Patent: US2009/278089, 2009, A1. Location in patent: Page/Page column 13
2,3-Difluoro-4-ethoxybenzeneboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Difluoro-4-ethoxybenzeneboronic acid manufacturers
- Product
- 2,3-Difluoro-4-ethoxybenzeneboronic acid 212386-71-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-28
- Product
- 2,3-Difluoro-4-ethoxybenzeneboronic acid cas 212386-71-5
- Price
- US $48.00-40.00/Kg
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200tons
- Release date
- 2021-04-18
- Product
- 2,3-Difluoro-4-ethoxybenzeneboronic acid 212386-71-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- According to customer requirements
- Release date
- 2022-10-19