ChemicalBook > CAS DataBase List > 2,3-Difluoro-4-ethoxybenzeneboronic acid

2,3-Difluoro-4-ethoxybenzeneboronic acid

Product Name: 2,3-Difluoro-4-ethoxybenzeneboronic acid
CAS No.: 212386-71-5
Chemical Name: 2,3-Difluoro-4-ethoxybenzeneboronic acid
Synonyms: 4-Ethoxy-2,3-difluorophenyl;4-Ethoxy-2,3-difluorphenylboronic acid;4-Ethoxy-2,3-difluorophenylboronic acid;2,3-Difluoro-4-ethoxyphenylboronic acid;2,3-Difluror-4-ethoxyphenylboronic acid;(4-ethoxy-2,3-difluorophenyl)boronicaci;2,3-Difluoro-4-ethoxybenzeneboronic acid;4-Ethoxy-2,3-difluorobenzeneboronic Acid;2,3-Difluoro-4-ethoxybenzeneboronicacid98%;B-(4-Ethoxy-2,3-difluorophenyl)boronic acid
CBNumber: CB7958102
Molecular Formula: C8H9BF2O3
Formula Weight: 201.96
MOL File: 212386-71-5.mol

Less

2,3-Difluoro-4-ethoxybenzeneboronic acid Property

Melting point:: 151-154
Boiling point:: 316.0±52.0 °C(Predicted)
Density: 1.29
vapor pressure: 0.002Pa at 25℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Methanol
form: Solid
pka: 7.69±0.58(Predicted)
color: White to Almost white
Water Solubility: 145mg/L at 20℃
InChI: InChI=1S/C8H9BF2O3/c1-2-14-6-4-3-5(9(12)13)7(10)8(6)11/h3-4,12-13H,2H2,1H3
InChIKey: OBKSFBWOZSQGGC-UHFFFAOYSA-N
SMILES: B(C1=CC=C(OCC)C(F)=C1F)(O)O
LogP: 2.3 at 23℃

Less

Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2931900090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: E1192
Product name: 4-Ethoxy-2,3-difluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: E1192
Product name: 4-Ethoxy-2,3-difluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $96
Updated: 2025/07/31

TRC

Product number: D473338
Product name: 2,3-Difluoro-4-ethoxyphenylboronicacid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: D473338
Product name: 2,3-Difluoro-4-ethoxyphenylboronicacid
Packaging: 1g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 035291
Product name: 2,3-Difluoro-4-ethoxyphenylboronic acid
Packaging: 5g
Price: $79
Updated: 2021/12/16

Less

2,3-Difluoro-4-ethoxybenzeneboronic acid Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

suzuki reaction

Flammability and Explosibility

Not classified

Synthesis

156573-09-0

121-43-7

212386-71-5

General procedure for the synthesis of 2,3-difluoro-4-bromophenyl ethyl ether and trimethyl borate as raw materials for the synthesis of 2,3-difluoro-4-ethoxyphenylboronic acid: intermediate compound T-2 (129.5 g) obtained in Example 1 was dissolved in dry tetrahydrofuran (Dry THF, 500 ml) and the resulting solution was cooled to -70 °C. Under nitrogen protection, n-butyllithium (n-BuLi, 500 ml) was slowly added dropwise and the reaction was stirred at -70 °C for 2 hours. Subsequently, a dry tetrahydrofuran (Dry THF) solution of trimethyl borate (129.5 g) was added slowly dropwise at the same temperature. Upon completion of the reaction, the reaction solution was warmed to room temperature and stirring was continued for 16 hours. The reaction mixture was acidified by adding 2N hydrochloric acid (200 ml) to the reaction mixture and subsequently extracted with toluene. The organic layer was washed sequentially with water and saturated aqueous sodium chloride solution and then dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give a light brown solid. Purification by recrystallization (heptane: toluene = 4:1, v/v) resulted in colorless crystals T-20 (117.2 g, yield: 71%).

References

[1] Patent: EP2484658, 2012, A1. Location in patent: Page/Page column 42
[2] Patent: JP5663957, 2015, B2. Location in patent: Paragraph 0137-0138; 0140
[3] Patent: US2009/278089, 2009, A1. Location in patent: Page/Page column 13

2,3-Difluoro-4-ethoxybenzeneboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2,3-Difluoro-4-ethoxybenzeneboronic acid Suppliers

Americas 1 China 180 Europe 3 France 1 Germany 2 India 3 Japan 3 Switzerland 1 The Netherlands 1 United Kingdom 3 United States 20 Global 218

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2802
Advantage: 65

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9309
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527621225
Email: 1791901229@qq.com
Country: China
ProdList: 6945
Advantage: 52

DKD Shijiazhuang Chemical Co., Ltd.

Tel: 0311-0311-67790228 15531158659
Fax: 66571013
Email: 1257738041@qq.com
Country: China
ProdList: 297
Advantage: 62

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Springchem New Material Technology Co.,Limited

Tel: +86-021-62885108 +8613917661608
Email: info@spring-chem.com
Country: China
ProdList: 2068
Advantage: 57

Wuhan Haizheng Industry & Trade Development Co. Ltd

Tel: 027-8866 0053/88660577/88660578
Fax: 027-8899 1911
Country: China
ProdList: 1073
Advantage: 55

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Xi'an Manareco New Materials Co., Ltd.

Tel: 029-68669089-8816
Fax: +86-29-68669073
Email: market@xarlm.com
Country: China
ProdList: 499
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Hunan Furui Biopharma Technology Co., Ltd.

Tel: 1822-2954721 15901640172
Fax: 0731-57805668
Email: sales03@hn-furui.com
Country: China
ProdList: 421
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

NINGBO INNO PHARMCHEM CO.,LTD.

Tel: 86-574-27787657
Fax: 86-574-27912196
Email: info@dearchem.com
Country: China
ProdList: 4613
Advantage: 58

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9986
Advantage: 58

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5674
Advantage: 50

Taizhou Jun Rui Import and Export Co., Ltd.

Tel: 0576-88808091 13958565781
Fax: 0576-88808091
Email: janney.liu@groundfortune.com
Country: China
ProdList: 61
Advantage: 55

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q2635253576
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
ProdList: 1984
Advantage: 55

Wuhan Chemwish Technology Co.， Ltd

Tel: 027-67849912
Fax: 027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 9148
Advantage: 60

Boron Technology (Beijing) Co., Ltd.

Tel: 010-010-15313962280 15313962280
Fax: 010-51669040
Email: 3004509780@qq.com
Country: China
ProdList: 824
Advantage: 55

Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 9021
Advantage: 60

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9288
Advantage: 55

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Nanjing XiLang Chemical Products Co., Ltd.

Tel: 18936048580
Email: chemxilang@163.com
Country: China
ProdList: 3909
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Suzhou Future Chemical Technology Co., Ltd.

Tel: 13921981169
Fax: -
Email: ftchem2016@163.com
Country: China
ProdList: 464
Advantage: 58

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10109
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shijiazhuang Yesheng Chemical Technology Co., Ltd

Tel: 18031147013 18031147013;
Fax: 0311-68030586
Email: yeshengchemical@163.com
Country: China
ProdList: 2606
Advantage: 58

Dalian lichuang Chemical Co., Ltd

Tel: 0411-0411-00000000 13644282108
Fax: -
Email: 3500508746@qq.com
Country: China
ProdList: 2896
Advantage: 55

Mirro Chemical Co.,Ltd.

Tel: 0086-15313090952
Fax: 0086-010-80236392
Country: China
ProdList: 2355
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

Shanghai Shuai Sun Industrial Co., Ltd.

Tel: 021-37590756 57450129
Fax: 021-57450128
Country: China
ProdList: 4284
Advantage: 58

Less

View Lastest Price from 2,3-Difluoro-4-ethoxybenzeneboronic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2,3-Difluoro-4-ethoxybenzeneboronic acid 212386-71-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-28

Guangzhou Sunton Biotechnology Co., Ltd.

Product: 2,3-Difluoro-4-ethoxybenzeneboronic acid cas 212386-71-5
Price: US $48.00-40.00/Kg
Min. Order: 1KG
Purity: 99%
Supply Ability: 200tons
Release date: 2021-04-18

Changzhou waston chemical technology Co.,Ltd

Product: 2,3-Difluoro-4-ethoxybenzeneboronic acid 212386-71-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: According to customer requirements
Release date: 2022-10-19

212386-71-5, 2,3-Difluoro-4-ethoxybenzeneboronic acidRelated Search:

4-Chloro-2-fluoro-3-methoxyphenylboronic acid 4-(Hydroxymethyl)phenylboronic acid 3-Carboxyphenylboronic acid 3-Tolylboronic acid 1-Methyl-4-pyrazole boronic acid pinacol ester 2,3-Difluorophenylboronic acid 4-Ethoxyphenylboronic acid 2,6-Difluoro-3-ethoxybenzeneboronic acid,2,6-Difluoro-3-ethoxybenzeneboronic acid 98% 2,3-Difluoro-6-ethoxyphenylboronic acid 4-ISOPROPOXY-2,3,5,6-TETRAFLUOROBENZENEBORONIC ACID 4-Benzyloxy-2,3-difluorobenzeneboronic acid 2,3-Difluoro-4-ethoxybenzeneboronic acid 4-ETHOXY-2,3,5,6-TETRAFLUOROBENZENEBORONIC ACID 4-BUTOXY-2,3,5,6-TETRAFLUOROBENZENEBORONIC ACID 4-PROPOXY-2,3,5,6-TETRAFLUOROBENZENEBORONIC ACID 2,3-DIFLUORO-4-PENTYLOXYPHENYLBORONIC ACID 2,3-DIFLUORO-4-(HEPTYLOXY)PHENYLBORONIC ACID 2,3-DIFLUORO-4-(N-HEXYLOXY)PHENYLBORONIC ACID

4-Ethoxy-2,3-difluorophenylboronic acid

4-Ethoxy-2,3-difluorophenyl

B-(4-Ethoxy-2,3-difluorophenyl)boronic acid

Boronicacid, B-(4-ethoxy-2,3-difluorophenyl)-

4-Ethoxy-2,3-difluorophenylboronic Acid (contains varying amounts of Anhydride)

2,3-Difluror-4-ethoxyphenylboronic acid

2,3-Difluoro-4-ethoxybenzeneboronic acid

Boronic acid, (4-ethoxy-2,3-difluorophenyl)- (9CI)

2,3-Difluoro-4-ethoxybenzeneboronic acid 98%

2,3-Difluoro-4-ethoxybenzeneboronicacid98%

2,3-Difluoro-4-ethoxyphenylboronic acid

2,3-Difluoro-4-ethoxybenzeneboronic acid cas

4-Ethoxy-2,3-difluorobenzeneboronic Acid

(4-ethoxy-2,3-difluorophenyl)boronicaci

2,3-Difluoro-4-ethoxyphenylboronic acid(contains varying amounts of Anhydride)

4-Ethoxy-2,3-difluorphenylboronic acid

212386-71-5

ETHOXY

Boronate Ester

Boronic Acid

Potassium Trifluoroborate

blocks

BoronicAcids

Bromides