3-Tolylboronic acid
- Product Name
- 3-Tolylboronic acid
- CAS No.
- 17933-03-8
- Chemical Name
- 3-Tolylboronic acid
- Synonyms
- AKOS BRN-0018;m-Boronotoluene;3-Boronotoluene;M-TOLYBORONICACID;-Tolylboronic acid;3-TOLYBORONIC ACID;3-TOLYLBORONIC ACID;RARECHEM AH PB 0229;M-TOLYLBORONIC ACID;m-Tolueneboronic acid
- CBNumber
- CB2385101
- Molecular Formula
- C7H9BO2
- Formula Weight
- 135.96
- MOL File
- 17933-03-8.mol
3-Tolylboronic acid Property
- Melting point:
- 160-162 °C(lit.)
- Boiling point:
- 290.4±33.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Water Solubility
- Slightly soluble in water
- pka
- 8.63±0.10(Predicted)
- form
- Powder and Chunks
- color
- Beige
- BRN
- 2935968
- InChI
- InChI=1S/C7H9BO2/c1-6-3-2-4-7(5-6)8(9)10/h2-5,9-10H,1H3
- InChIKey
- BJQCPCFFYBKRLM-UHFFFAOYSA-N
- SMILES
- B(C1=CC=CC(C)=C1)(O)O
- CAS DataBase Reference
- 17933-03-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- ED7788888
- TSCA
- No
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 393614
- Product name
- m-Tolylboronic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $25.8
- Updated
- 2025/07/31
- Product number
- 393614
- Product name
- m-Tolylboronic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $26.8
- Updated
- 2025/07/31
- Product number
- M1314
- Product name
- 3-Methylphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $27
- Updated
- 2025/07/31
- Product number
- M1314
- Product name
- 3-Methylphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $78
- Updated
- 2025/07/31
- Product number
- 05-1049
- Product name
- m-Tolylboronic acid, min. 97%
- Packaging
- 5g
- Price
- $145
- Updated
- 2024/03/01
3-Tolylboronic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white Cryst
Uses
3-methylphenylboronic acid can be used in Suzuki coupling reactions and is studied in the field of chemical engineering.
Application
3-Tolylboronic acid is an impurity of Eltrombopag, Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough.
Synthesis
121-43-7
591-17-3
17933-03-8
The general procedure for the synthesis of 3-methylphenylboronic acid from trimethyl borate and 3-bromomethylbenzene is as follows: 0.10 mol (0.1 eq.) of 3-bromomethylbenzene, 1.1 mol (1.1 eq.) of magnesium scraps, a few iodine crystals, and 800 mL of tetrahydrofuran (THF) were added to a reaction flask, stirred and heated to reflux. When the Grignard reaction was initiated, 0.90 mol (0.9 eq.) of 3-bromomethylbenzene was slowly added dropwise under reflux conditions, and the reaction was continued at reflux after completion of the dropwise addition. After completion of the reaction, the reaction system was cooled down to -50.0 °C. Subsequently, 2.2 mol (2.2 eq.) of trimethyl borate was slowly added dropwise and the reaction was kept at a low temperature until the feedstock was completely consumed. Upon completion of the reaction, the temperature was gradually increased and water was added to quench the reaction. Then, hydrochloric acid was added dropwise to adjust the pH to 1-2 and the reaction was continued with stirring. After completion of the reaction, the solvent was removed by rotary evaporation and the product was dried by filtration to give 0.90 mol of 3-methylphenylboronic acid as a white solid with 0.03% water content, 98.86% purity and 90.0% yield.
References
[1] Patent: CN106946924, 2017, A. Location in patent: Paragraph 0009; 0020; 0023; 0026
[2] Patent: US5183653, 1993, A
3-Tolylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Tolylboronic acid manufacturers
- Product
- Eltrombopag Impurity 41 17933-03-8
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95.18%
- Supply Ability
- 10g/month
- Release date
- 2023-05-10
- Product
- 3-Tolylboronic acid 17933-03-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%Min
- Supply Ability
- 1000kg
- Release date
- 2023-03-12
- Product
- 3-Tolylboronic acid 17933-03-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10