3-Carboxyphenylboronic acid

Product Name: 3-Carboxyphenylboronic acid
CAS No.: 25487-66-5
Chemical Name: 3-Carboxyphenylboronic acid
Synonyms: 3-BORONOBENZOIC ACID;m-carboxybenzeneboronicacid;AKOS BRN-0007;"25487-66-5 ";3-CarboxyphenyL;3-borono-benzoicaci;RARECHEM AH PB 0148;m-borono-benzoicaci;3-Carboxyphenylboron;Benzoic acid, 3-borono-
CBNumber: CB3376096
Molecular Formula: C7H7BO4
Formula Weight: 165.94
MOL File: 25487-66-5.mol

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3-Carboxyphenylboronic acid Property

Melting point:: 243-247 °C (lit.)
Boiling point:: 434.5±47.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka: 4.21±0.10(Predicted)
form: Crystalline Powder
color: Off-white
Water Solubility: 2.5 g/100 mL
BRN: 2967400
InChI: InChI=1S/C7H7BO4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4,11-12H,(H,9,10)
InChIKey: DBVFWZMQJQMJCB-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=CC(B(O)O)=C1
CAS DataBase Reference: 25487-66-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 37/39-26-36
WGK Germany: 2
RTECS: CY8750000
HazardClass: IRRITANT
HS Code: 29163990
Toxicity: mouse,LD50,intravenous,2560mg/kg (2560mg/kg),"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 456764
Product name: 3-Carboxyphenylboronic acid
Purity: ≥95%
Packaging: 1g
Price: $52.12
Updated: 2025/07/31

Sigma-Aldrich

Product number: 456764
Product name: 3-Carboxyphenylboronic acid
Purity: ≥95%
Packaging: 10g
Price: $67.35
Updated: 2025/07/31

TCI Chemical

Product number: C2028
Product name: 3-Carboxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: C2028
Product name: 3-Carboxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $109
Updated: 2025/07/31

Strem Chemicals

Product number: 05-0399
Product name: 3-Carboxyphenylboronic acid, min. 97%
Packaging: 1g
Price: $62
Updated: 2024/03/01

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3-Carboxyphenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

3-Carboxyphenylboronic acid is off-white crystalline powder

Uses

suzuki reaction

Uses

3-Carboxyphenylboronic acid can be used as a substrate in the preparation of:

Biaryl derivatives by reacting with bromoaniline through the Suzuki-Miyaura coupling reaction.
Boronic acid-functionalized block copolymer.
1H-Imidazo[1,2-a]quinoxaline derivatives.

Uses

3-Carboxyphenylboronic acid is used in Suzuki coupling chemistry.1,2,3

Synthesis

150255-96-2

25487-66-5

1. Synthesis of 3-carboxyphenylboronic acid: 10 g (68 mmol) of 3-cyanophenylboronic acid was suspended in 40 mL of ethylene glycol with 15.26 g (272 mmol, 4 eq.) of potassium hydroxide powder, heated to 175 °C and maintained for 3 hours. After completion of the reaction, the reaction mixture was cooled and diluted with 60 mL of water. The pH was adjusted to 2-3 with 32% hydrochloric acid solution, colorless crystalline 3-carboxyphenylboronic acid was precipitated and the product was separated by filtration. The resulting crystals were washed with water and dried under mild vacuum at 35 °C. The final product was 10.04 g in mass. The final product was 10.04 g (60.5 mmol, 89% yield).

References

[1] Patent: US2009/286995, 2009, A1. Location in patent: Page/Page column 4

3-Carboxyphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

3-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 3-(3-PYRIDINYL)BENZOIC ACID

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3-Carboxyphenylboronic acid Suppliers

Americas 1 Belgium 2 China 397 Europe 5 France 4 Germany 13 India 38 Japan 4 Jordan 1 Russia 1 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 25 United States 76 Global 571

Hebei Maison Chemical Co.,Ltd.

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Energy Chemical

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View Lastest Price from 3-Carboxyphenylboronic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Carboxyphenylboronic acid 25487-66-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-25

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 3-Carboxyphenylboronic acid 25487-66-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-28

Hebei Chuanghai Biotechnology Co,.LTD

Product: 3-Carboxyphenylboronic acid 25487-66-5
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2024-08-19

25487-66-5, 3-Carboxyphenylboronic acidRelated Search:

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3-Carboxyphenylboronicacid,min.97%

3-CARBOXYBENZENEBORONIC ACID 98%

3-Carboxyphenylboronic Acid (contains varying amounts of Anhydride)

3-Carboxyphenylboronic acid ,98%

3-Carboxyphenylboronic acid, min. 97%

(3-Formyloxyphenyl)boronicacid

3-Carboxyphenylboron

3-(dihydroxyboryl)benzoic acid(SALTDATA: FREE)

3-Carboxyphenylboronic acid, 98% 5GR

"25487-66-5 "

3-Carboxyphenylboronic acid Eltrombopag Lumacaftor

3-CarboxyphenyL

Benzoic acid, 3-borono-

3-Carboxyphenylboronic acid 25487-66-5

3-Carboxybenzeneboronic Acid extrapure, 97%

Eltrombopag Impurity 31

Benzeneboronic acid, m-carboxy-

3-Carboxyphenylboronic acid, 97%

3-Carboxyphenylboronic acid - [C2160]

25487-66-5

25487-66-6

C7H7BO4

HO2CC6H4BOH2

HOOCC6H4BOH2

BORONIC ACID

B (Classes of Boron Compounds)

Boronic Acids

Boronic Acids and Derivatives

Aryl

Organometallic Reagents

Substituted Boronic Acids

B (Classes of Boron Compounds)

CHIRAL CHEMICALS

Boronic Acids & Esters

Phenyls & Phenyl-Het

Boronic Acids

Boronic Acids and Derivatives

organic or inorganic borate

Boronic Acids & Esters

Phenyls & Phenyl-Het

Boronic acids

Boronic Acid