OXITROPIUM BROMIDE

Product Name: OXITROPIUM BROMIDE
CAS No.: 30286-75-0
Chemical Name: OXITROPIUM BROMIDE
Synonyms: Ba 253;ba253br;Oxivent;Ventilat;Tersigan;tersigat;oxitropium;ba-253-br-l;Oxitropiumbromid;oxitropiobromuro
CBNumber: CB1727939
Molecular Formula: C19H26BrNO4
Formula Weight: 412.32
MOL File: 30286-75-0.mol

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OXITROPIUM BROMIDE Property

Melting point:: 203-204° (dec)
alpha: D21 -25° (c = 2.0 in water)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Very soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
color: Off-White to Pale Yellow
Stability:: Hygroscopic

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Safety

Toxicity: LD50 orl-rat: 2250 mg/kg DRFUD44,117,79

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000709
Product name: Oxitropium bromide
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000709
Price: $220
Updated: 2024/03/01

TRC

Product number: O847165
Product name: Oxitropium bromide
Packaging: 10mg
Price: $105
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003715
Product name: OXITROPIUM BROMIDE
Purity: 95.00%
Packaging: 5MG
Price: $503.89
Updated: 2021/12/16

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OXITROPIUM BROMIDE Chemical Properties,Usage,Production

Description

Oxitropium bromide is an analog of the anticholinergics methscopolamine bromide and ipratropium bromide, useful in the treatment of bronchial asthma. Cited advantages include a long duration of action and lack of cardiovascular effects.

Chemical Properties

White or almost white, crystalline powder.

Originator

Boehringer Ingelheim (W. Germany)

Uses

Anticholinergic; treatment of reversible airways obstruction.

Uses

Oxitropium Bromide is an anticholinergic agent.

Manufacturing Process

14.5 g (0.05 mol) of (-)-norscopolamine and 5.4 g (0.05 mol) of ethyl bromide were dissolved in 300 cc of acetonitrile, 5.3 g (0.05 mol) of anhydrous sodium carbonate were suspended in the solution, and the suspension was heated at the boiling point for 10 hours. After a boiling time of 2.5 and 5 hours, respectively, the supply of ethyl bromide and sodium carbonate in the reaction mixture was replenished by adding each time 5.4 g (0.05 mol) of ethyl bromide and 5.3 g (0.05 mol) of anhydrous sodium carbonate. At the end of 10 hours of boiling, the inorganic sodium salts which had separated out were separated by vacuum filtration, the filter cake was washed with acetonitrile, and the acetonitrile was distilled out of the filtrate. The distillation residue was dissolved in ether, the solution was extracted with a small amount of water and then dried, and the ether was distilled off, yielding raw (-)-N-ethylnorscopolamine.
7.0 g (0.022 mol) of (-)-N-ethylnorscopolamine were dissolved in acetonitrile, 10.4 g (0.11 mol) of methyl bromide were added to the solution, and the mixture was allowed to stand at room temperature. The crystalline precipitate formed thereby was collected and recrystallized from acetonitrile.8.9 g (97.8% of theory) of white crystalline (-)-N-ethylnorscopolamine methobromide, melting point 203°C to 204°C (decomposition), were obtained.

brand name

Oxivent (Boehringer Ingelheim);TERSIGAT.

Therapeutic Function

Anticholinergic bronchodilator

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. An anticholinergic bronchodilator. When heated to decomposition it emits very toxic fumes of NOx and Brí.

OXITROPIUM BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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OXITROPIUM BROMIDE Suppliers

China 20 Europe 2 France 1 Germany 1 India 4 United Kingdom 1 United States 5 USA 1 Global 35

ChemStrong Scientific Co.,Ltd

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Hefei TNJ Chemical Industry Co.,Ltd.

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Dayang Chem (Hangzhou) Co.,Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

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30286-75-0, OXITROPIUM BROMIDERelated Search:

BECLOMETHASONE Tiotropium bromide (r)-budesonide Methyl bromide OXITROPIUM BROMIDE IMPURITY D OXITROPIUM BROMIDE IMPURITY B OXITROPIUM BROMIDE

(-)-n-ethyl-norhyoscine-methobromide

3-oxa-9-azoniatricyclo(3.3.1.0(sup2,4))nonane,9-ethyl-7-(3-hydroxy-1-oxo-2-ph

ba253br

ba-253-br-l

bromurodeoxitropio

Oxivent

Scopolamine ethobromide

Tersigan

Ventilat

Oxitropiumbromid

N-Ethylnorscopolammonium bromide

OXITROPIUM BROMIDE

enylpropoxy)-9-methyl-,bromide,(7(s)-(1-alpha,2-beta,4-beta,5-alpha,7-beta))

n-ethyl-norscopolaminemethobromide

oxitropiobromuro

oxitropium

oxytropiumbromide

tersigat

3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 9-ethyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-, bromide, [7(S)-(1a,2b,4b,5a,7b)]-

3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 9-ethyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-, bromide, (1a,2b,4b,5a,7b)- (9CI)

Ba 253

Hyoscine ethobromide

N-Ethylnorscopolamine methylbromide

N-Ethylnorscopolamine-methyl bromide

N-Ethylscopolammonium bromide (6CI, 7CI)

Oxitropium bromide CRS

(1R,2R,4S,5S,7s,9R)-9-ethyl-7-(((S)-3-hydroxy-2-phenylpropanoyl)oxy)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide

30286-75-0

C19H26NO4Br

C19H26BrNO4