6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID
- Product Name
- 6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID
- CAS No.
- 26018-73-5
- Chemical Name
- 6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID
- Synonyms
- 2-Carboxy-6-chlorobenzo[b]thiophene;6-chlorobenzothiophene-2-carboxylic acid;6-chloro-2-benzothiophenecarboxylic acid;6-Chlorobenzo[b]thiophen-2-carboxylic acid;6-Chlorobenzo[b]thiophene-2-carboxylic acid;6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID;Benzo[b]thiophene-2-carboxylic acid, 6-chloro-;2-Carboxy-6-chlorobenzo[b]thiophene, 2-Carboxy-6-chloro-1-benzothiophene, 2-Carboxy-6-chlorothianaphthene
- CBNumber
- CB1730610
- Molecular Formula
- C9H5ClO2S
- Formula Weight
- 212.65
- MOL File
- 26018-73-5.mol
6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID Property
- Melting point:
- 271-274
- Boiling point:
- 408.6±25.0 °C(Predicted)
- Density
- 1.546±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- form
- Solid
- pka
- 3.34±0.30(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C9H5ClO2S/c10-6-2-1-5-3-8(9(11)12)13-7(5)4-6/h1-4H,(H,11,12)
- InChIKey
- AVAGKGZNBMZOLD-UHFFFAOYSA-N
- SMILES
- C12=CC(Cl)=CC=C1C=C(C(O)=O)S2
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C367278
- Product name
- 6-Chloro-1-benzothiophene-2-carboxylicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C367278
- Product name
- 6-Chloro-1-benzothiophene-2-carboxylicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C367278
- Product name
- 6-Chloro-1-benzothiophene-2-carboxylicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR14043
- Product name
- 6-Chlorobenzo[b]thiophene-2-carboxylicacid
- Packaging
- 500mg
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 047320
- Product name
- 6-Chloro-1-benzothiophene-2-carboxylic acid
- Purity
- >95%
- Packaging
- 500mg
- Price
- $26
- Updated
- 2021/12/16
6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
104795-85-9
26018-73-5
1. To a solution of DMF (7 mL) containing 600 mg (3.23 mmol) of 4-chloro-2-nitrobenzaldehyde was added 559 mg (4.04 mmol) of potassium carbonate and 294 μL (3.23 mmol) of methyl thioglycolate sequentially at 0°C. The reaction mixture was stirred for 30 min. at 0°C followed by continued stirring at room temperature for 24 hours. The reaction mixture was stirred at 0°C for 30 minutes, followed by continued stirring at room temperature for 24 hours. Upon completion of the reaction, the mixture was poured into ice water, the precipitate was collected by filtration, and the precipitate was dissolved in ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate and concentrated to give 630 mg (86% yield) of methyl 6-chlorobenzo[b]thiophene-2-carboxylate as a white solid.1H NMR (CDCl3, 300 MHz): δ 3.95 (s, 3H), 7.88 (dd, J = 8.6, 1.9 Hz, 1H), 7.79 (d, J = 8.6 Hz, 1H), 7.85 (d, J = 8.6 Hz, 1H), 7.79 (d, J = 8.6 Hz, 1H). 7.85 (d, J = 1.9 Hz, 1H), 8.02 (s, 1H). 2. 6.95 mL of aqueous 1N LiOH was added to a 630 mg (2.78 mmol) solution of methyl 6-chlorobenzo[b]thiophene-2-carboxylate in THF (5 mL), and the reaction mixture was stirred for 4 h at room temperature. Upon completion of the reaction, the pH was adjusted to 2-3 with 1N HCl and subsequently extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give 579 mg (98% yield) of 6-chlorobenzo[b]thiophene-2-carboxylic acid as a white solid.MS (ISP): 211.0 (M-H)-. 3. 139 mg (0.65 mmol) of 6-chlorobenzo[b]thiophene-2-carboxylic acid was converted to 52 mg (0.14 mmol) of (6-chlorobenzo[b]thiophen-2-ylmethyl)-[2-(3,4-dichlorophenyl)ethyl]amine by reference to the method of Example S3 (Steps a to b), the product was a colorless liquid.MS (ISP): 370.0 (M+H )+.
References
[1] Patent: US2007/185113, 2007, A1. Location in patent: Page/Page column 13
[2] Patent: WO2016/100184, 2016, A1. Location in patent: Paragraph 00270
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 20, p. 4793 - 4807
6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID Suppliers
- Tel
- 18014808303 18014808303
- Fax
- +86-25-58353700
- sales@rennotech.com
- Country
- China
- ProdList
- 60
- Advantage
- 58
- Tel
- 15281070185
- 2865097598@qq.com
- Country
- China
- ProdList
- 898
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 21-57721279
- Fax
- QQ：14057904
- sales@shydchem.com.cn
- Country
- China
- ProdList
- 998
- Advantage
- 56
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 029-86538357
- Fax
- 029-87871708
- Country
- China
- ProdList
- 234
- Advantage
- 57
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
View Lastest Price from 6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID manufacturers
- Product
- 6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID 26018-73-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16