SE 175

Product Name: SE 175
CAS No.: 258278-64-7
Chemical Name: SE 175
Synonyms: SE 175;SE 175 >=97%;NO PRODRUG, SE 175;JDIVRBDMTYQVOK-UHFFFAOYSA-N;S-(4-NITROOXYMETHYLBENZOYL)METHYLTHIOSALICYLATE;2-[[4-[(NITROOXY)METHYL]BENZOYL]THIO]-BENZOIC ACID, METHYL ESTER;Benzoic acid, 2-[[4-[(nitrooxy)methyl]benzoyl]thio]-, methyl ester
CBNumber: CB1732391
Molecular Formula: C16H13NO6S
Formula Weight: 347.34
MOL File: 258278-64-7.mol

More

Less

SE 175 Property

Boiling point:: 493.8±45.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMF:50.0(Max Conc. mg/mL);143.53(Max Conc. mM)
DMSO:35.0(Max Conc. mg/mL);100.47(Max Conc. mM)
Ethanol:11.0(Max Conc. mg/mL);31.58(Max Conc. mM)
form: A crystalline solid
InChI: 1S/C16H13NO6S/c1-22-15(18)13-4-2-3-5-14(13)24-16(19)12-8-6-11(7-9-12)10-23-17(20)21/h2-9H,10H2,1H3
InChIKey: JDIVRBDMTYQVOK-UHFFFAOYSA-N
SMILES: COC(=O)c1ccccc1SC(=O)c2ccc(CO[N+]([O-])=O)cc2

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
Storage Class: 11 - Combustible Solids

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S2189
Product name: SE 175
Purity: ≥97%
Packaging: 10mg
Price: $123
Updated: 2025/07/31

Cayman Chemical

Product number: 82340
Product name: SE 175
Purity: ≥97%
Packaging: 5mg
Price: $59
Updated: 2024/03/01

Cayman Chemical

Product number: 82340
Product name: SE 175
Purity: ≥97%
Packaging: 10mg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 82340
Product name: SE 175
Purity: ≥97%
Packaging: 50mg
Price: $448
Updated: 2024/03/01

Cayman Chemical

Product number: 82340
Product name: SE 175
Purity: ≥97%
Packaging: 100mg
Price: $783
Updated: 2024/03/01

More

Less

SE 175 Chemical Properties,Usage,Production

Description

SE 175 is an organic nitrate compound of the same general class as nitroglycerin. These nitrate compounds can act as NO-donors in vivo following reductive transformation of the nitrate group to nitric oxide. The nitroxyacylated thiosalicylates, such as SE 175, were developed in an effort to facilitate this reductive process and accelerate the release of NO. SE 175 is stable in buffer or saline solution. In the intact rat, it stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC₅₀ of 20 μM, which is intermediate in potency between nitroglycerine and isosorbide dinitrate.

Uses

SE 175 is an organic nitrate compound that acts as an NO donor in vivo following reductive transformation of the nitrate group to nitric oxide. SE 175 stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC50 of 0.20 μM[1].

References

[1] Endres S,et al. NO-Donors, part 3: nitrooxyacylated thiosalicylates and salicylates - synthesis and biological activities(#). Eur J Med Chem. 1999;34(11):895-901. DOI:10.1016/s0223-5234(99)00110-5

SE 175 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

SE 175 Suppliers

China 24 Switzerland 1 United States 5 Global 30

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Aoki Biotechnology (Shenzhen) Co., Ltd.

Tel: 18566777408
Country: CHINA
ProdList: 156
Advantage: 58

258278-64-7, SE 175Related Search:

SE 175 2-[(4-METHYLBENZYL)SULFANYL]BENZENECARBOXYLIC ACID

2-[[4-[(NITROOXY)METHYL]BENZOYL]THIO]-BENZOIC ACID, METHYL ESTER

JDIVRBDMTYQVOK-UHFFFAOYSA-N

NO PRODRUG, SE 175

S-(4-NITROOXYMETHYLBENZOYL)METHYLTHIOSALICYLATE

SE 175

Benzoic acid, 2-[[4-[(nitrooxy)methyl]benzoyl]thio]-, methyl ester

SE 175 >=97%

258278-64-7

Substrates by Enzyme

Nitric Oxide Synthase/NO Donor

BioChemical

Biochemicals and Reagents

Enzyme Substrates

Enzymes, Inhibitors, and Substrates

Nitric Oxide DonorsEnzyme Substrates

Nitric Oxide Synthase/NO Donor

Nitric Oxide and Cell Stress

Nitric Oxide Metabolism

Substrates by Enzyme