BENZYL N-HYDROXYCARBAMATE
- Product Name
- BENZYL N-HYDROXYCARBAMATE
- CAS No.
- 3426-71-9
- Chemical Name
- BENZYL N-HYDROXYCARBAMATE
- Synonyms
- Z-HNOH;Z-NHOH;Cbz-NH-OH;N-Z-HYDROXYLAMINE;N-CBZ-HYDROXYLAMINE;Benyl N-hydroxycarbame;Benzyl hydroxycarbamate;Benyl N-hydroxycarbaMate;BENZYL N-HYDROXYCARBAMATE;N-CARBOBENZOXYHYDROXYLAMINE
- CBNumber
- CB1747920
- Molecular Formula
- C8H9NO3
- Formula Weight
- 167.16
- MOL File
- 3426-71-9.mol
BENZYL N-HYDROXYCARBAMATE Property
- Melting point:
- 65-70 °C(lit.)
- Boiling point:
- 295.73°C (rough estimate)
- Density
- 1.2917 (rough estimate)
- refractive index
- 1.5570 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.20±0.23(Predicted)
- color
- White
- Sensitive
- Moisture Sensitive
- BRN
- 1074034
- InChI
- InChI=1S/C8H9NO3/c10-8(9-11)12-6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
- InChIKey
- PQBSPTAPCMSZAA-UHFFFAOYSA-N
- SMILES
- C(OCC1=CC=CC=C1)(=O)NO
- CAS DataBase Reference
- 3426-71-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 323276
- Product name
- N-(Benzyloxycarbonyl)hydroxylamine
- Purity
- 99%
- Packaging
- 5g
- Price
- $42.56
- Updated
- 2025/07/31
- Product number
- 323276
- Product name
- N-(Benzyloxycarbonyl)hydroxylamine
- Purity
- 99%
- Packaging
- 25g
- Price
- $91
- Updated
- 2025/07/31
- Product number
- C1557
- Product name
- N-Carbobenzoxyhydroxylamine
- Purity
- >97.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $71
- Updated
- 2025/07/31
- Product number
- C1557
- Product name
- N-Carbobenzoxyhydroxylamine
- Purity
- >97.0%(HPLC)(N)
- Packaging
- 25g
- Price
- $238
- Updated
- 2025/07/31
- Product number
- B285915
- Product name
- N-Benzyloxycarbonylhydroxylamine
- Packaging
- 25g
- Price
- $335
- Updated
- 2021/12/16
BENZYL N-HYDROXYCARBAMATE Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Solid
Uses
N-(Benzyloxycarbonyl)hydroxylamine reacts with cyclohepta-1,3-diene to produce 6-oxa-7-aza-bicyclo[3.2.2]non-8-ene-7-carboxylic acid benzyl ester.
Synthesis
501-53-1
3426-71-9
The general procedure for the synthesis of N-(benzylcarbonyloxy)hydroxylamine from benzyl chloroformate was as follows: 92.9 g (0.876 mol) of sodium carbonate (Na2CO3) and 300 mL of pure water were added to a 1 L three-necked flask, and the sodium carbonate was completely dissolved by mechanical stirring. Subsequently, 46.83 g (0.674 mol) of hydroxylamine hydrochloride was added, and 220 mL of dichloromethane solution containing 100 g (0.587 mol) of benzyl chloroformate was stirred and slowly added dropwise at room temperature for about 4 hours. After the dropwise addition, stirring was continued at room temperature for 1 h. Then 300 mL of pure water was added to separate the organic and aqueous layers. The aqueous layer was extracted with dichloromethane (150 mL each time, 3 times in total), and all the dichloromethane phases were combined, washed with 300 mL of saturated saline, and then dried with 20.0 g of anhydrous sodium sulfate. The dried solution was distilled under reduced pressure at 45 °C to remove the solvent to give the crude product I. The crude product was dissolved in 100 mL of dichloromethane, ensuring complete dissolution, then cooled to 0 °C in an ice-water bath and 300 mL of petroleum ether was added slowly and dropwise. The solution was crystallized at 0 °C for 1 h. The crystalline product was washed with pre-cooled mixed solvent (200 mL, petroleum ether: dichloromethane = 3:1, v/v) and dried at 35 °C under reduced pressure. Finally, it was stirred at 0 °C for 5 h to give 63.0 g of white powdery solid in 64% overall yield.
References
[1] Organic and Biomolecular Chemistry, 2009, vol. 7, # 21, p. 4531 - 4538
[2] Journal of Organic Chemistry, 2009, vol. 74, # 22, p. 8690 - 8694
[3] Journal of the American Chemical Society, 2010, vol. 132, # 37, p. 12862 - 12864
[4] Synthetic Communications, 2010, vol. 40, # 5, p. 642 - 646
[5] Helvetica Chimica Acta, 1991, vol. 74, # 8, p. 1653 - 1670
BENZYL N-HYDROXYCARBAMATE Preparation Products And Raw materials
Raw materials
Preparation Products
BENZYL N-HYDROXYCARBAMATE Suppliers
- Tel
- --
- Fax
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- chemcontrol@nextra.sk
- Country
- Slovakia
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View Lastest Price from BENZYL N-HYDROXYCARBAMATE manufacturers
- Product
- BENZYL N-HYDROXYCARBAMATE 3426-71-9
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-25
- Product
- Cbz-NH-OH 3426-71-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-07-18
- Product
- BENZYL N-HYDROXYCARBAMATE 3426-71-9
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10MT
- Release date
- 2018-12-16