L-Canavanine sulfate
- Product Name
- L-Canavanine sulfate
- CAS No.
- 2219-31-0
- Chemical Name
- L-Canavanine sulfate
- Synonyms
- L-CANAVANINE SULPHATE;CANAVANINE SULFATE;canavanine sulphate;L-CANAVANINE SULFATE;CANAVANINE SULFATE, L-;CANAVANINE SULFATE, L-(P);L-Canavanine Sulfate L-CANAVANINE SULFATE SALT;CANAVANINE SULFATE, L-(RG);L-CANAVANINE SULFATE HYDRATE
- CBNumber
- CB0746906
- Molecular Formula
- C5H14N4O7S
- Formula Weight
- 274.25
- MOL File
- 2219-31-0.mol
L-Canavanine sulfate Property
- Melting point:
- 160-165 °C (dec.)
- storage temp.
- 2-8°C
- solubility
- H2O: 100 mg/mL
- form
- powder
- color
- white
- BRN
- 6121291
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 2219-31-0(CAS DataBase Reference)
- EPA Substance Registry System
- L-Canavanine sulfate (2219-31-0)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 36-26
- RIDADR
- 2811
- WGK Germany
- 3
- HS Code
- 2925290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C9758
- Product name
- L-Canavanine sulfate salt
- Purity
- ≥99% (TLC), powder
- Packaging
- 1g
- Price
- $242
- Updated
- 2024/03/01
- Product number
- C9758
- Product name
- L-Canavanine sulfate salt
- Purity
- ≥99% (TLC), powder
- Packaging
- 5g
- Price
- $919
- Updated
- 2024/03/01
- Product number
- C0018
- Product name
- L-Canavanine Sulfate Hydrate
- Purity
- >97.0%(T)
- Packaging
- 100mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- C9758
- Product name
- L-Canavanine sulfate salt
- Purity
- ≥99% (TLC), powder
- Packaging
- 100mg
- Price
- $56.1
- Updated
- 2024/03/01
- Product number
- C9758
- Product name
- L-Canavanine sulfate salt
- Purity
- ≥99% (TLC), powder
- Packaging
- 250mg
- Price
- $71.4
- Updated
- 2024/03/01
L-Canavanine sulfate Chemical Properties,Usage,Production
Uses
A Nitric Oxide Synthase inhibitor
Uses
Canavanine sulfate salt has been used:
- as a translation inhibitor in yeast translation studies
- as a component of synthetic complete (SC) drop-out medium for screening yeast
- for screening Saccharomyces cerevisiae in canavanine mutation frequency assay
Definition
ChEBI: An organic sulfate salt obtained by combining L-canavanine with one molar equivalent of sulfuric acid.
General Description
Canavanine is a homolog of arginine and a non-protein amino acid. It is present in plants like alfalfa, cloves, beans onions and sprouts. Canavanine is synthesized from L-canavaninosuccinic acid and the biosynthetic pathway was first elucidated in jack bean plant.
Biological Activity
NO synthase inhibitor.
Biochem/physiol Actions
Canavanine is a naturally occurring?L-amino acid that competes and interferes with?L-arginine-utilizing enzymes due to its structural similarity with this?L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). It acts as a substrate for arginyl tRNA and is incorporated during protein synthesis leading to aberrant canavanyl proteins. Supplementation with canavanine worsens the alfalfa induced Systemic lupus erythematosus (SLE) like syndrome and its incorporation with endosome and proteasome disrupts the antigen processing.
Purification Methods
Recrystallise the sulfate by dissolving (~1g) in H2O (10mL), and adding with stirring 0.5 to 1.0 volumes of 95% EtOH whereby crystals separate. These are collected, washed with Me2CO/EtOH (1:1) and dried over P2O5 in a vacuum. [Hunt & Thompson Biochemical Preparations 13 416 1971, Feacon & Bell Biochem J 59 221 1955, Beilstein 4 III 1636, 4 IV 3188.]
L-Canavanine sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-Canavanine sulfate manufacturers
- Product
- L-CANAVANINE SULFATE 2219-31-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- L-CANAVANINE SULFATE 2219-31-0
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-24