N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE

Product Name: N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE
CAS No.: 13880-05-2
Chemical Name: N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE
Synonyms: NAT, TRIS-acrylamide;N-[Tris(hydroxymethyL;ACRYLAMIDOTRISHYDROXYMETHYLMETHANE;N-(1,3-Dihydroxy-2-(hydroxymethyl);Acryloylaminomethylidynetrimethanol;N-[TRIS(HYDROXYMETHYL)METHYL]ACRYLAMIDE;N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE;N-acryloyl (trihydroxymethyl) aminomethane;N-[Tris(hydroxymethyl)methyl]acrylamide,98%;2-ACRYLAMIDO-2-HYDROXYMETHYL-1,3-PROPANEDIOL
CBNumber: CB1753970
Molecular Formula: C7H13NO4
Formula Weight: 175.18
MOL File: 13880-05-2.mol

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N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE Property

Melting point:: 136-141 °C(lit.)
Boiling point:: 510.8±50.0 °C(Predicted)
Density: 1.272±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.74±0.46(Predicted)
form: solid
Water Solubility: Soluble in water.
Sensitive: Light Sensitive & Hygroscopic
BRN: 2081162
InChI: InChI=1S/C7H13NO4/c1-2-6(12)8-7(3-9,4-10)5-11/h2,9-11H,1,3-5H2,(H,8,12)
InChIKey: MVBJSQCJPSRKSW-UHFFFAOYSA-N
SMILES: C(NC(CO)(CO)CO)(=O)C=C
CAS DataBase Reference: 13880-05-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
F: 8-10-21
HS Code: 29241900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 364959
Product name: N-[Tris(hydroxymethyl)methyl]acrylamide
Purity: contains ≤7% KCl, 93%
Packaging: 5g
Price: $77.42
Updated: 2025/07/31

Sigma-Aldrich

Product number: 364959
Product name: N-[Tris(hydroxymethyl)methyl]acrylamide
Purity: contains ≤7% KCl, 93%
Packaging: 25g
Price: $370.5
Updated: 2025/07/31

TRC

Product number: D489808
Product name: N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 146574
Product name: N-Acryloyltris(hydroxymethyl)aminomethane
Purity: 95%
Packaging: 5g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: U898
Product name: N-[Tris(hydroxymethyl)methyl]acrylamide
Packaging: 5g
Price: $77.3
Updated: 2021/12/16

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N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE Chemical Properties,Usage,Production

Chemical Properties

White crystals or crystalline powder

Uses

N-[Tris(hydroxymethyl)methyl] acrylamide is used to prepare N-(5-hydroxymethyl-2-phenyl-[1,3]dioxan-5-yl)-acrylamide by reaction with benzaldehyde.

Synthesis

814-68-6

77-86-1

13880-05-2

N-Acryloyl(tris(hydroxymethyl)aminomethane was synthesized from acryloyl chloride and tris(hydroxymethyl)aminomethane according to the method reported by Pucci et al. (Eur. Polym. J. 1991, 27, 1101). The procedure was as follows: to a stirred 3N potassium hydroxide methanol solution of tris(hydroxymethyl)aminomethane (3.00 g, 24.8 mmol), acryloyl chloride (3.60 mL, 44.6 mmol) was added slowly and dropwise at 0 °C, keeping the pH of the reaction system between 8 and 8. The reaction mixture was continued to be stirred at 0 °C for 3 h. The reaction was then naturally warmed to room temperature and continued for 4 h. The reaction was carried out at 0 °C. After completion of the reaction, the mixture was filtered and the filtrate was evaporated to dryness under vacuum. The resulting solid was purified by recrystallization from methanol to afford the target compound, N-acryloyl(trimethylol)aminomethane (3.78 g, 87%), as a white powder with a melting point of 205 °C. The product was purified by recrystallization from methanol. The product was characterized by the following data: IR (NaCl, cm^-1): 3420 (br, s), 1653 (s), 1560 (m), 1540 (m), 1018 (m); 1H NMR (300 MHz, DMSO-d6): δ 3.56 (d, 6H, J = 5.7 Hz, CH2), 4.76 (t, 3H, J = 5.7 Hz, OH), 5.54 (dd, 1H, J = 2.4, 9.9 Hz, Ha), 6.02 (dd, 1H, J = 2.4, 17.1 Hz, Hb), 6.37 (dd, 1H, J = 9.9, 17.1 Hz, Hc), 7.42 (s, 1H, NH).

References

[1] Journal of Organic Chemistry, 2008, vol. 73, # 14, p. 5602 - 5605
[2] Patent: WO2016/185425, 2016, A1. Location in patent: Page/Page column 57
[3] Macromolecular Bioscience, 2013, vol. 13, # 4, p. 512 - 522
[4] Tetrahedron, 2001, vol. 57, # 50, p. 9979 - 9987
[5] Tetrahedron Letters, 1991, vol. 32, # 11, p. 1437 - 1440

N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE Suppliers

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View Lastest Price from N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE 13880-05-2
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-18

Henan Aochuang Chemical Co.,Ltd.

Product: N-[Tris(hydroxymethyl)methyl]acrylamide 13880-05-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

13880-05-2, N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANERelated Search:

Stannous oxalate Tris(hydroxymethyl)aminomethane Methacrylamide N-TERT-BUTYLACRYLAMIDE N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE

2-ACRYLAMIDO-2-HYDROXYMETHYL-1,3-PROPANEDIOL

N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE

N-(2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL)-2-PROPENAMIDE

N-[TRIS(HYDROXYMETHYL)METHYL]ACRYLAMIDE

ACRYLAMIDOTRISHYDROXYMETHYLMETHANE

N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]acrylamide

NAT, TRIS-acrylamide

Acryloylaminomethylidynetrimethanol

N-[1,1-Bis(hydroxymethyl)-2-hydroxyethyl]propenamide

N-[1,1-Di(hydroxymethyl)-2-hydroxyethyl]acrylamide

N-[Tris(hydroxyMethyl)Methyl]acrylaMide contains <=7% KCl, 93%

N-(1,3-Dihydroxy-2-(hydroxyMethyl)propan-2-yl)acrylaMide

N-[Tris(hydroxymethyl)methyl]acrylamide,98%

N-(1,3-Dihydroxy-2-(hydroxymethyl)

N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]prop-2-enamide

1,2-dihydroxyethyl-(hydroxymethyl)-methyl-(1-oxoprop-2-enyl)ammonium

N-[Tris(hydroxymethyL

2-Propenamide, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-

TIANFUCHEM--13880-05-2---N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE

<i>N</i>-[Tris(hydroxymethyl)methyl]acrylamide

N-acryloyl (trihydroxymethyl) aminomethane

13880-05-2

CH2CHCONHCCH2OH3

H2CCHCONHCCH2OH3

AMINE

Naphthyridine,Quinoline