(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)
- Product Name
- (PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)
- CAS No.
- 182912-74-9
- Chemical Name
- (PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)
- Synonyms
- IAB5;IAβ5;LPFFD;IA-BETA5;LEU-PRO-PHE-PHE-ASP;H-LEU-PRO-PHE-PHE-ASP-OH;Beta-Sheet Breaker Peptide iAβ5;BETA-SHEET BREAKER PEPTIDE IA-BETA5;[PRO18, ASP21] BETA-AMYLOID (17-21);BETA-SHEET BREAKER PEPTIDE IA-BETA5P
- CBNumber
- CB1755202
- Molecular Formula
- C33H43N5O8
- Formula Weight
- 637.72
- MOL File
- 182912-74-9.mol
(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) Property
- Boiling point:
- 980.0±65.0 °C(Predicted)
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- ≥63.7 mg/mL in DMSO; ≥16.33 mg/mL in EtOH; ≥6.9 mg/mL in H2O with ultrasonic
- form
- solid
- pka
- 2.88±0.10(Predicted)
- color
- White to off-white
- Sequence
- Leu-Pro-Phe-Phe-Asp
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- A1005
- Product name
- Beta-SheetBreakerPeptideiAβ5
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A1005
- Product name
- Beta-SheetBreakerPeptideiAβ5
- Packaging
- 10mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- A1005
- Product name
- Beta-SheetBreakerPeptideiAβ5
- Packaging
- 25mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- PEP0000210
- Product name
- [PRO18,ASP21]BETA-AMYLOID(17-21),IAB5
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $588.19
- Updated
- 2021/12/16
(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) Chemical Properties,Usage,Production
Uses
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.
in vivo
β-Sheet Breaker Peptide iAβ5 (100 nmol/rat; Intra-amygdala injection; 7 days) coinjected with Aβ1-42 (5 nmol) into in the rat amygdala, blocks Aβ1-42 neurotoxicity in tissue culture, and amyloid fibril formation in the rat model[1].
β-Sheet Breaker Peptide iAβ5 (100 nmol/rat, 200 nmol/rat; Intra-amygdaloid injection; 7 days) followed by Aβ1-42 (5 nmol), induces disassembly of pre-existing Aβ fibrils in vivo, and leads to a reversal or prevention of Aβ-induced histopathological changes in rat model[2].
References
[1] Soto C, et al. Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nat Med. 1998 Jul;4(7):822-6. DOI:10.1038/nm0798-822
[2] Sigurdsson EM, et al. In vivo reversal of amyloid-beta lesions in rat brain. J Neuropathol Exp Neurol. 2000 Jan;59(1):11-7. DOI:10.1093/jnen/59.1.11
[3] Okada Y, et al. Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis. Org Lett. 2015 Sep 4;17(17):4264-7. DOI:10.1021/acs.orglett.5b02057
(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) Preparation Products And Raw materials
Raw materials
Preparation Products
(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) Suppliers
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- brunschwig@brunschwig.nl
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- The Netherlands
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