5-Nitroindole

Product Name: 5-Nitroindole
CAS No.: 6146-52-7
Chemical Name: 5-Nitroindole
Synonyms: 5-NITRO-1H-INDOLE;NSC 520594;Nitroindole;5-nitro-indol;5-NITROINDOLE;5-INTRO INDOLE;5-Nitroindole>5-Nitroindole,99%;5-Nitroindole,98+%;1H-Indole, 5-nitro-
CBNumber: CB1758162
Molecular Formula: C8H6N2O2
Formula Weight: 162.15
MOL File: 6146-52-7.mol

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5-Nitroindole Property

Melting point:: 140-142 °C (lit.)
Boiling point:: 288.82°C (rough estimate)
Density: 1.3264 (rough estimate)
refractive index: 1.5770 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Dichloromethane, Ethyl Acetate, Methanol
form: Crystalline Powder or Needles
pka: 15.25±0.30(Predicted)
color: Yellow
BRN: 383777
InChI: InChI=1S/C8H6N2O2/c11-10(12)7-1-2-8-6(5-7)3-4-9-8/h1-5,9H
InChIKey: OZFPSOBLQZPIAV-UHFFFAOYSA-N
SMILES: N1C2=C(C=C([N+]([O-])=O)C=C2)C=C1
CAS DataBase Reference: 6146-52-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-41
Safety Statements: 26-39-45-36/37
WGK Germany: 3
RTECS: NM1168200
F: 8
Hazard Note: Irritant
HazardClass: IRRITANT, IRRITANT-HARMFUL
HS Code: 29339900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Eye Dam. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N17602
Product name: 5-Nitroindole
Purity: 98%
Packaging: 5g
Price: $53.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: N17602
Product name: 5-Nitroindole
Purity: 98%
Packaging: 25g
Price: $107
Updated: 2025/07/31

TCI Chemical

Product number: N0400
Product name: 5-Nitroindole
Purity: >98.0%(GC)
Packaging: 5g
Price: $66
Updated: 2025/07/31

TCI Chemical

Product number: N0400
Product name: 5-Nitroindole
Purity: >98.0%(GC)
Packaging: 25g
Price: $263
Updated: 2025/07/31

TRC

Product number: N496280
Product name: 5-Nitroindole
Packaging: 25g
Price: $150
Updated: 2021/12/16

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5-Nitroindole Chemical Properties,Usage,Production

Chemical Properties

Yellow-Green Cyrstalline Solid, soluble in ethanol, diethyl ether, propylene glycol, petroleum ether and most non-volatile oils, insoluble in glycerol and mineral oils.

Application

Reactant for preparation of:

Pharmaceutically active 2-oxo-1-pyrrolidine analogues
Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
Protein Kinase Inhibitors and antiproliferative agents
Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4)
Antifungal agents
Cannabinoid receptor type 1 (CB1) antagonists
Potential anticancer agents
Potential antivascular agents
Selective Anti-leukemic agents
Anti human immunodeficiency virus subtype 1 (HIV-1) agents

Uses

5-Nitroindole (cas# 6146-52-7) is a reagent involved in the synthesis of a variety of biochemical compounds, including: 2-oxo-1-pyrrolidine analogs, mGlu4 allosteric modulators, protein kinase inhibitors, antiproliferative agents, anti-HIV 1 agents, antifungal agents, anti-leukemic agents, antivascular agents, anticancer agents, and cannabinoid receptor type 1 (CB1) antagonists.

Synthesis

In 500ml round bottom flask add 27.2g2-sodium-1-acetylindole (0.1mo1), add 100ml acetic acid, cool down to 12??C, in 1h dropwise finish 19ml fuming nitric acid, the reaction is complete, carefully poured into 250ml crushed water, add 160gNaOH, slowly raise the temperature to 70°C, keep for 20h, pumping filtration, wash with 2*100 ml ice water washing, drying, obtained 14.6g of golden yellow crystals 5-Nitroindole, yield 90.1%, purity 98.5%.

Purification Methods

Decolourise (charcoal) 5-nitroindole and recrystallise it twice from aqueous EtOH or recrystallise it from octane. It has UV: 265 and 324nm (EtOH). [Beilstein 20 III/IV 3194, 20/7 V 41.]

5-Nitroindole Preparation Products And Raw materials

Raw materials

Sodium acetate Quinoline Ethanol Acetic anhydride Ethyl pyruvate Sodium bisulfite polyphosphoric acid Tetrahydrofuran Cupric oxide 4-Nitrophenylhydrazine Ethyl acetate Hydrochloric acid Sodium bicarbonate Nitric acid Acetic acid Sodium hydroxide Indole

Preparation Products

1-METHYL-5-NITRO-1H-INDOLE 5-IODOINDOLE Zafirlukast

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5-Nitroindole Suppliers

Americas 1 Austria 1 Belgium 2 Canada 4 China 334 Czech Republic 1 Europe 3 Germany 9 India 55 Japan 4 Slovakia 1 South Korea 1 Switzerland 4 Ukraine 1 United Kingdom 24 United States 68 Global 513

Changzhou Joyous Chemical Co., Ltd.

Tel: 0519-85607258 13912342323;
Fax: 0519-85607278
Email: sales@joyouschem.com
Country: China
ProdList: 292
Advantage: 60

BEIJING GOLDEN OLIVE COMPANY

Tel: 15311296095
Email: mary@goldolive.com
Country: China
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Advantage: 58

Shanghai Alan Pharmaceutical Co., LTD

Tel: 021-58099609-8008 13816260319
Email: 251218799@qq.com
Country: China
ProdList: 139
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Jinan Dexinjia Bio&Tech Co., Ltd

Tel: 0531-82375878 15865278590
Fax: 0531-82375893
Email: daisy@jndxj.com
Country: China
ProdList: 1634
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
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future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

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View Lastest Price from 5-Nitroindole manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-NITRO-1H-INDOLE 6146-52-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-19

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Nitroindole 6146-52-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-09

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Nitroindole 6146-52-7
Price: US $1.00/PCS
Min. Order: 1PCS
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-10

6146-52-7, 5-NitroindoleRelated Search:

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5-NITROINDOLE

5-NITRO-1H-INDOLE

5-nitro-indol

Nitroindole

5-Nitroindole,99%

5-Nitroindole,98+%

NSC 520594

5-Nitroindolyl radical

1H-Indole, 5-nitro-

5-Nitroindole in stock Factory

5-Nitroindole&gt

5-INTRO INDOLE

INDOLE DERIVATIVE6146-52-7

5-nitro-1H-indole - [N31173]

6146-52-7

C8H6NO2

Organic Nonlinear Optical Materials

Indoles

Simple Indoles

Building Blocks

Heterocyclic Building Blocks

Functional Materials

Organic Nonlinear Optical Materials

Simple Indoles

blocks

IndolesOxindoles

NitroCompounds

Indole/indoline/oxindole

indole derivative

Indole and Indoline

Indoles and derivatives

IndoleDerivative

Pyrroles & Indoles

Indole

Indoles

Indole Derivatives

IndolesPhotonic and Optical Materials

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Heterocyclic Building Blocks

Materials Science

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Non-Linear Optical (NLO) Materials

Organic and Printed Electronics

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Heterocycle-Indole series

C7 to C9

Pyrroles & Indoles