1-METHYL-5-NITRO-1H-INDOLE

Product Name: 1-METHYL-5-NITRO-1H-INDOLE
CAS No.: 29906-67-0
Chemical Name: 1-METHYL-5-NITRO-1H-INDOLE
Synonyms: 1-Methyl-5-Nitroindole;1-METHYL-5-NITRO-1H-INDOLE;1H-Indole, 1-Methyl-5-nitro-;1-Methyl-5-nitro-1H-indole ,97%
CBNumber: CB1207231
Molecular Formula: C9H8N2O2
Formula Weight: 176.17
MOL File: 29906-67-0.mol

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1-METHYL-5-NITRO-1H-INDOLE Property

Melting point:: 167 °C
Boiling point:: 339.2±15.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly)
form: Solid
color: Dark Yellow to Very Dark Yellow
InChI: InChI=1S/C9H8N2O2/c1-10-5-4-7-6-8(11(12)13)2-3-9(7)10/h2-6H,1H3
InChIKey: PXBQSCHRKSBGKV-UHFFFAOYSA-N
SMILES: N1(C)C2=C(C=C([N+]([O-])=O)C=C2)C=C1

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Safety

Risk Statements: 22-41
Safety Statements: 26-39
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M320970
Product name: 1-Methyl-5-nitro-1H-indole
Packaging: 5g
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: R932
Product name: 1-Methyl-5-nitroindole
Packaging: 10g
Price: $140
Updated: 2021/12/16

Matrix Scientific

Product number: 058680
Product name: 1-Methyl-5-nitro-1H-indole
Purity: 97%
Packaging: 5g
Price: $187
Updated: 2021/12/16

Apolloscientific

Product number: OR70135
Product name: 1-Methyl-5-nitro-1H-indole
Packaging: 1g
Price: $24
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H54-1-AF
Product name: 1-Methyl-5-nitro-1H-indole
Packaging: 1g
Price: $26
Updated: 2021/12/16

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1-METHYL-5-NITRO-1H-INDOLE Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

1-Methyl-5-nitro-1H-indole is used as a reagent in the synthesis of the antiasthmatic drug Zafirlukast (Z125000).

Synthesis

6146-52-7

616-38-6

29906-67-0

91482-63-2

Example 14 Synthesis of 1-methyl-5-nitroindole. To a 500 mL three-necked flask equipped with a thermocouple, condenser tube, and constant pressure dropping funnel was added 5-nitroindole (20.0 g, 123 mmol), potassium carbonate (4.0 g, 29 mmol), N,N-dimethylformamide (80 mL), and dimethyl carbonate (22 mL, 261.4 mmol). The reaction mixture was heated to reflux. The reaction progress was monitored by high performance liquid chromatography (HPLC) or thin layer chromatography (TLC) (unfolding agent: heptane solution of 30% ethyl acetate). After 3 hours of refluxing, complete conversion of 5-nitroindole was confirmed by the analytical method described above. The reaction mixture was then cooled to 10±5°C and diluted with water (160 mL), at which point a yellow precipitate was generated. The mixture was continued to be stirred at room temperature for 2 h, after which the solid product was collected by filtration, washed with water (100 mL), and finally dried under high vacuum at 60-65 °C for 24 h. 1-methyl-5-nitroindole (21.1 g, 97.1% yield) was obtained as a yellow solid.

References

[1] Patent: US6326501, 2001, B1

1-METHYL-5-NITRO-1H-INDOLE Preparation Products And Raw materials

Raw materials

5-Nitroindole Quinoline Ethanol Potassium hydroxide Acetone Ethyl pyruvate Polyphosphoric acid Cupric oxide 4-Nitrophenylhydrazine Dichloromethane Iodomethane

Preparation Products

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1-METHYL-5-NITRO-1H-INDOLE Suppliers

Belgium 1 China 138 France 1 India 5 United Kingdom 1 United States 13 Global 159

Shanghai Alan Pharmaceutical Co., LTD

Tel: 021-58099609-8008 13816260319
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J & K SCIENTIFIC LTD.

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Energy Chemical

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Adamas Reagent, Ltd.

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XiaoGan ShenYuan ChemPharm co,ltd

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Shanghai Ennopharm Co., Ltd.

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Tongchuang Pharma(Suzhou). Co., Ltd.

Tel: 0512-63263366 18912765016
Fax: 0512-6326 3366
Email: tongtf110@sina.com
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View Lastest Price from 1-METHYL-5-NITRO-1H-INDOLE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-METHYL-5-NITRO-1H-INDOLE 29906-67-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-08

Career Henan Chemical Co

Product: 1-METHYL-5-NITRO-1H-INDOLE 29906-67-0
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-06

29906-67-0, 1-METHYL-5-NITRO-1H-INDOLERelated Search:

9-Ethyl-3-nitrocarbazole 3-Methyl-6-Nitro-1h-Indole 1-Methyl-3-nitro-1H-indole 4-METHYL-7-NITRO-1H-INDOLE 1-methyl-5-nitro-1H-indole-2-carboxylic acid 3-METHYL-6-NITROINDOLE 2-METHYL-5-NITRO-1H-INDOLE-3-CARBALDEHYDE 2-METHYL-5-NITRO-1H-INDOLE 5-Methyl-4-nitro-1H-indole 4-methyl-5-nitro-1H-indole 2-Methyl-4-nitro-1H-indole 5-Nitroindole 9-METHYL-3-NITRO-9H-CARBAZOLE 2-[(4-BROMOPHENYL)SULFANYL]-1-METHYL-5-NITRO-1H-INDOLE-3-CARBALDEHYDE CHEMBRDG-BB 5280909 1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE 1-(5-O-(DIMETHOXYTRITYL)-BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE 3-FORMYL-5-NITROINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-Methyl-5-Nitroindole

1-METHYL-5-NITRO-1H-INDOLE

1-Methyl-5-nitro-1H-indole ,97%

1H-Indole, 1-Methyl-5-nitro-

29906-67-0

Heterocycle-Indole series