CHEMBRDG-BB 5280909

Product Name: CHEMBRDG-BB 5280909
CAS No.: 89159-60-4
Chemical Name: CHEMBRDG-BB 5280909
Synonyms: ML-354;CHEMBRDG-BB 5280909;1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol;1H-Indole-2-methanol, 1-methyl-5-nitro-3-phenyl-;(1-METHYL-5-NITRO-3-PHENYL-1H-INDOL-2-YL)METHANOL;(1-methyl-5-nitro-3-phenyl-1H-indol-2-yl)methanol(SALTDATA: FREE)
CBNumber: CB9163102
Molecular Formula: C16H14N2O3
Formula Weight: 282.29
MOL File: 89159-60-4.mol

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CHEMBRDG-BB 5280909 Property

Melting point:: 178-179 °C(Solv: 1,4-dioxane (123-91-1))
Boiling point:: 544.0±50.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: ≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
pka: 14.47±0.10(Predicted)
form: powder
color: white to beige

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Safety

RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19120
Product name: ML-354
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19120
Product name: ML-354
Purity: ≥95%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 19120
Product name: ML-354
Purity: ≥95%
Packaging: 10mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 19120
Product name: ML-354
Purity: ≥95%
Packaging: 25mg
Price: $343
Updated: 2024/03/01

Tocris

Product number: 5387
Product name: ML354
Purity: ≥98%(HPLC)
Packaging: 10
Price: $149
Updated: 2021/12/16

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CHEMBRDG-BB 5280909 Chemical Properties,Usage,Production

Description

ML-354 is an indole-based, proteinase-activated receptor 4 (PAR4) antagonist (IC₅₀ = 140 nM) that exhibits 71-fold selectivity for PAR4 over PAR1 (IC₅₀ = 10 μM) in isolated human platelets.

Uses

ML-354 is a selective protease activated receptor 4 ( PAR-4) antagonist used for its antithrombotic effects.

Biochem/physiol Actions

ML354 is a potent and selective PAR4 (protease activated receptor-4) antagonist.

IC 50

140 nm

storage

Store at -20°C

References

[1]. wen, w., young, s., duvernay, m., schulte, m., nance, k., & melancon, b. et al. substituted indoles as selective protease activated receptor 4 (par-4) antagonists: discovery and sar of ml354. bioorganic & medicinal chemistry letters. 2014; 24(19): 4708-4713.

CHEMBRDG-BB 5280909 Preparation Products And Raw materials

Raw materials

Preparation Products

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CHEMBRDG-BB 5280909 Suppliers

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89159-60-4, CHEMBRDG-BB 5280909Related Search:

5-AMINO-2-METHYLINDOLE 2,3-DIMETHYL-5-NITROINDOLE 2-METHYL-5-NITROINDOLE 2-methyl-3-phenyl-1H-indole 3-phenylindole (1-METHYL-1H-INDOL-2-YL)-METHANOL 5-AMINO-2,3-DIMETHYLINDOLE ETHYL 6-TERT-BUTYL-2-METHYLNICOTINATE 5-AMINO-1-N-METHYLINDOLE 1-METHYL-5-NITRO-1H-INDOLE CHEMBRDG-BB 5280909

CHEMBRDG-BB 5280909

(1-METHYL-5-NITRO-3-PHENYL-1H-INDOL-2-YL)METHANOL

(1-methyl-5-nitro-3-phenyl-1H-indol-2-yl)methanol(SALTDATA: FREE)

ML-354

1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol

1H-Indole-2-methanol, 1-methyl-5-nitro-3-phenyl-

89159-60-4