5-AMINO-1-N-METHYLINDOLE
- Product Name
- 5-AMINO-1-N-METHYLINDOLE
- CAS No.
- 102308-97-4
- Chemical Name
- 5-AMINO-1-N-METHYLINDOLE
- Synonyms
- TIMTEC-BB SBB010309;1-methylindol-5-amine;5-AMINO-N-METHYLINDOLE;1-Methyl-5-aminoindole;5-Amino-1-methylindole;5-AMINO-1-N-METHYLINDOLE;1-METHYL-1H-INDOL-5-AMINE;5-Amino-1-methyl-1H-indole;1H-Indol-5-aMine, 1-Methyl-;1-METHYL-1H-INDOL-5-YLAMINE
- CBNumber
- CB4306926
- Molecular Formula
- C9H10N2
- Formula Weight
- 146.19
- MOL File
- 102308-97-4.mol
5-AMINO-1-N-METHYLINDOLE Property
- Melting point:
- 102 °C
- Boiling point:
- 143-144 °C(Press: 2 Torr)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly)
- form
- Solid
- pka
- 5.05±0.10(Predicted)
- color
- Black
- CAS DataBase Reference
- 102308-97-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-36-22-20/21/22
- Safety Statements
- 36/37/39-26-22
- RIDADR
- 2811
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CDS014563
- Product name
- 5-amino-1-N-Methylindole
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 100 mg
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- A613488
- Product name
- 5-Amino-1-N-methylindole
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3H30-1-U5
- Product name
- 5-Amino-1-methyl-1H-indole
- Purity
- 97%
- Packaging
- 500mg
- Price
- $21
- Updated
- 2021/12/16
- Product number
- OR6792
- Product name
- 5-Amino-1-methyl-1H-indole
- Purity
- 97%
- Packaging
- 500mg
- Price
- $21
- Updated
- 2021/12/16
- Product number
- OR6792
- Product name
- 5-Amino-1-methyl-1H-indole
- Purity
- 97%
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
5-AMINO-1-N-METHYLINDOLE Chemical Properties,Usage,Production
Chemical Properties
Brown solid
Uses
5-Amino-1-N-methylindole (CAS# 102308-97-4) is an indole derivative and building block, used in the copper-catalyzed synthesis of sulfonamides.
Synthesis
29906-67-0
102308-97-4
The general procedure for the synthesis of 1-methyl-5-aminoindole using 1-methyl-5-nitroindole as starting material was as follows: 10% Pd/C catalyst (0.18 g/g by mass of the feedstock) was added to the feedstock solution (THF dosage of 54 mL/g of feedstock) dissolved in THF. The reaction flask was sealed and air was removed by vacuum. Subsequently, a hydrogen-filled balloon was attached to the flask. The reaction was stirred continuously at room temperature for 24 to 48 hours or monitored by TLC until the feedstock completely disappeared. Upon completion of the reaction, the mixture was filtered through diatomaceous earth. The filtrate was collected and the solvent was removed by rotary evaporation to give a brown solid product in 100% yield. The structure of the product was confirmed by 1H NMR (DMSO-d6) and 13C NMR (DMSO-d6): 1H NMR (DMSO-d6): δ 7.15-7.05 (m, 2H), 6.71 (dd, J = 3.0, 0.9 Hz, 1H), 6.57 (dd, J = 8.5, 2.1 Hz, 1H), 6.12 (dd, J = 3.0, 0.9 Hz, 1H), 3.67 (s, 3H); 13C NMR (DMSO-d6): δ 141.30, 131.12, 129.49, 129.44, 129.41, 112.31, 110.11, 104.21, 99.13, 32.86.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 1202 - 1213
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 10, p. 3531 - 3541
[3] New Journal of Chemistry, 2015, vol. 39, # 7, p. 5360 - 5365
[4] Patent: CN104163815, 2017, B. Location in patent: Paragraph 0065; 0066; 0068
[5] Patent: CN107163029, 2017, A. Location in patent: Paragraph 0049; 0053; 0054; 0055; 0056; 0057; 0058
5-AMINO-1-N-METHYLINDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-AMINO-1-N-METHYLINDOLE manufacturers
- Product
- 5-AMINO-1-N-METHYLINDOLE 102308-97-4
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2018-08-09