ChemicalBook > CAS DataBase List > SB 200646 HYDROCHLORIDE

SB 200646 HYDROCHLORIDE

Product Name
SB 200646 HYDROCHLORIDE
CAS No.
143797-63-1
Chemical Name
SB 200646 HYDROCHLORIDE
Synonyms
SB 200646;SB200646HCl;SB 200646 HYDROCHLORIDE;SB-200646, 10 mM in DMSO;N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea;N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea;1-(1-Methyl-1H-indol-5-yl)-3-pyridin-3-yl-urea;Urea, N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl-;N-(1-METHYL-1H-INDOL-5-YL)-N'-3-PYRIDINYLUREA HYDROCHLORIDE;N-(1-METHYL-1H-5-INDOLYL)-N'-(3-PYRIDINYL)UREA HYDROCHLORIDE
CBNumber
CB7234079
Molecular Formula
C15H14N4O
Formula Weight
266.3
MOL File
143797-63-1.mol
More
Less

SB 200646 HYDROCHLORIDE Property

storage temp. 
2-8°C
solubility 
DMSO: ~26 mg/mL, soluble
form 
solid
color 
pale yellow
Water Solubility 
Water: 1 mg/mL (NaN mM)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Tocris
Product number
1371
Product name
SB200646hydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$116
Updated
2021/12/16
Tocris
Product number
1371
Product name
SB200646hydrochloride
Purity
≥98%(HPLC)
Packaging
50
Price
$488
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009920
Product name
SB 200646 HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$496.01
Updated
2021/12/16
Matrix Scientific
Product number
147865
Product name
N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea
Purity
95%
Packaging
5mg
Price
$740
Updated
2021/12/16
Matrix Scientific
Product number
147865
Product name
N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea
Purity
95%
Packaging
10mg
Price
$1110
Updated
2021/12/16
More
Less

SB 200646 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

SB 200646 Hydrochloride is a 5-HT2C antagonist.

Definition

ChEBI: SB 200646 is a member of indoles.

Biological Activity

5-HT 2C/2B receptor antagonist, selective over 5-HT 1A . Affinities are 7.4 (pA 2 ), 6.9 (pK i ) and 5.2 (pK i ) for 5-HT 2B , 2C and 2A respectively. Orally active in vivo .

in vivo

SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons[1].
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1].

Animal Model:Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)[1]
Dosage:20 mg/kg
Administration:Intravenous injection; daily; for 21 days
Result:Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.

IC 50

5-HT2B Receptor: 7.5 (pKi); 5-HT2C Receptor: 6.9 (pKi); 5-HT2A Receptor: 5.2 (pKi)

SB 200646 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SB 200646 HYDROCHLORIDE Suppliers

China 26 Germany 1 Switzerland 1 United Kingdom 1 United States 6 Global 35
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
Henan Weitesi Chemical Technology Co. LTD
Tel
0371-0371-55135753 18003832934
Fax
QQ：2853979818
Email
2853979818@qq.com
Country
China
ProdList
9991
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4810
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58

143797-63-1, SB 200646 HYDROCHLORIDERelated Search:

m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate SB 202190 SB 431542 SB 743921 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime Pracinostat 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 4'-CHLORO-3-METHOXYCINNAMANILIDE SB-705498 SB 203580 SB 225002 SB242235 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride MMP-2/MMP-9 INHIBITOR IV SB-756050 SB 200646 HYDROCHLORIDE 5-AMINO-1-N-METHYLINDOLE 5-METHYL-1-(3-PYRIDYLCARBAMOYL)-1,2,3,5-TETRAHYDROPYRROLO [2,3-F]INDOLE

  • SB 200646
  • SB 200646 HYDROCHLORIDE
  • N-(1-METHYL-1H-5-INDOLYL)-N'-(3-PYRIDINYL)UREA HYDROCHLORIDE
  • N-(1-METHYL-1H-INDOL-5-YL)-N'-3-PYRIDINYLUREA HYDROCHLORIDE
  • SB200646HCl
  • N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea
  • N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea
  • 1-(1-Methyl-1H-indol-5-yl)-3-pyridin-3-yl-urea
  • Urea, N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl-
  • electrophysiological,5-HT Receptor,SNC,Serotonin Receptor,Inhibitor,antipsychotic,inhibit,5-hydroxytryptamine Receptor,5-HT2B,SB200646,anxiolytic,5-HT2C,neurons,SB 200646,dopaminergic,SB-200646
  • SB-200646, 10 mM in DMSO
  • 143797-63-1
  • C15H14N4OHCl