SB-756050
- Product Name
- SB-756050
- CAS No.
- 447410-57-3
- Chemical Name
- SB-756050
- Synonyms
- SB-756050;SB-756050, >98%;SB756050, 10 mM in DMSO;SB756050;SB 756050;SB-756050;1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane;1H-1,4-Diazepine, 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro-;G protein-coupled Bile Acid Receptor 1,inhibit,TGR5,Inhibitor,SB756050,GPBAR1,G-protein coupled receptor 19,GPCR19
- CBNumber
- CB93162605
- Molecular Formula
- C21H28N2O8S2
- Formula Weight
- 500.59
- MOL File
- 447410-57-3.mol
SB-756050 Property
- Boiling point:
- 653.1±65.0 °C(Predicted)
- Density
- 1.328±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.25 mg/ml; DMSO: 10 mg/ml
- form
- A crystalline solid
- pka
- -6.97±0.20(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27998
- Product name
- SB-756050
- Packaging
- 50mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 27998
- Product name
- SB-756050
- Packaging
- 100mg
- Price
- $208
- Updated
- 2024/03/01
- Product number
- 27998
- Product name
- SB-756050
- Packaging
- 10mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- CS-6960
- Product name
- SB756050
- Purity
- 99.32%
- Packaging
- 10mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-6960
- Product name
- SB756050
- Purity
- 99.32%
- Packaging
- 25mg
- Price
- $135
- Updated
- 2021/12/16
SB-756050 Chemical Properties,Usage,Production
Description
SB-756050 is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50 = 1.3 μM for the human receptor). It is selective for TGR5 over the farnesoid X receptor (FXR) and a panel of other receptors, channels, and transporters. SB-756050 (10-100 mg/kg) decreases fasting glucose levels and increases glucose disposal rate and insulin secretion in diabetic Goto Kakizaki rats.
Uses
SB756050 is a selective TGR5 agonist. SB756050 has the potential for type 2 diabetes treatment.
in vivo
SB756050 is well‐tolerated; it is readily absorbed, exhibited nonlinear pharmacokinetics with a less than dose‐proportional increase in plasma exposure above 100 mg, and demonstrates no significant changes in exposure when co‐administered with sitagliptin. SB756050 demonstrates highly variable pharmacodynamic effects both within dose groups and between doses, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different[1].
References
[1] Hodge RJ, et al. Safety, Pharmacokinetics, and Pharmacodynamic Effects of a Selective TGR5 Agonist, SB-756050, in Type 2 Diabetes. Clin Pharmacol Drug Dev. 2013 Jul;2(3):213-22. DOI:10.1002/cpdd.34
SB-756050 Preparation Products And Raw materials
Raw materials
Preparation Products
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