ChemicalBook > CAS DataBase List > SB-756050

SB-756050

Product Name: SB-756050
CAS No.: 447410-57-3
Chemical Name: SB-756050
Synonyms: SB-756050;SB-756050, >98%;SB-756050 ，S6741;SB756050, 10 mM in DMSO;SB756050;SB 756050;SB-756050;1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane;1H-1,4-Diazepine, 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro-;G protein-coupled Bile Acid Receptor 1,inhibit,TGR5,Inhibitor,SB756050,GPBAR1,G-protein coupled receptor 19,GPCR19
CBNumber: CB93162605
Molecular Formula: C21H28N2O8S2
Formula Weight: 500.59
MOL File: 447410-57-3.mol

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SB-756050 Property

Boiling point:: 653.1±65.0 °C(Predicted)
Density: 1.328±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.25 mg/ml; DMSO: 10 mg/ml
form: A crystalline solid
pka: -6.97±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27998
Product name: SB-756050
Packaging: 50mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 27998
Product name: SB-756050
Packaging: 100mg
Price: $208
Updated: 2024/03/01

Cayman Chemical

Product number: 27998
Product name: SB-756050
Packaging: 10mg
Price: $33
Updated: 2024/03/01

ChemScene

Product number: CS-6960
Product name: SB756050
Purity: 99.32%
Packaging: 10mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-6960
Product name: SB756050
Purity: 99.32%
Packaging: 25mg
Price: $135
Updated: 2021/12/16

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SB-756050 Chemical Properties,Usage,Production

Description

SB-756050 is an agonist of the bile acid G protein-coupled receptor TGR5 (EC₅₀ = 1.3 μM for the human receptor). It is selective for TGR5 over the farnesoid X receptor (FXR) and a panel of other receptors, channels, and transporters. SB-756050 (10-100 mg/kg) decreases fasting glucose levels and increases glucose disposal rate and insulin secretion in diabetic Goto Kakizaki rats.

Uses

SB756050 is a selective TGR5 agonist. SB756050 has the potential for type 2 diabetes treatment.

in vivo

SB756050 is well‐tolerated; it is readily absorbed, exhibited nonlinear pharmacokinetics with a less than dose‐proportional increase in plasma exposure above 100 mg, and demonstrates no significant changes in exposure when co‐administered with sitagliptin. SB756050 demonstrates highly variable pharmacodynamic effects both within dose groups and between doses, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different^[1].

References

[1] Hodge RJ, et al. Safety, Pharmacokinetics, and Pharmacodynamic Effects of a Selective TGR5 Agonist, SB-756050, in Type 2 Diabetes. Clin Pharmacol Drug Dev. 2013 Jul;2(3):213-22. DOI:10.1002/cpdd.34

SB-756050 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB-756050 Suppliers

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447410-57-3, SB-756050Related Search:

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SB-756050

1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane

SB756050;SB 756050;SB-756050

SB-756050, >98%

1H-1,4-Diazepine, 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro-

G protein-coupled Bile Acid Receptor 1,inhibit,TGR5,Inhibitor,SB756050,GPBAR1,G-protein coupled receptor 19,GPCR19

SB756050, 10 mM in DMSO

SB-756050 ，S6741

447410-57-3