1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE

Product Name: 1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE
CAS No.: 191421-10-0
Chemical Name: 1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE
Synonyms: 5-NIdR;2'-DEOXY-NITRO INDOLE NUCLEOSIDE;5-Nitroindole 2'-deoxyribonucleoside;1-(b-D-2-Deoxyribofuranosyl)-5-nitroindole;1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole;1-(2-Deoxy-b-D-ribofuranosyl)-5-nitroindole;1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE;1H-Indole, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-nitro-;1-(2-Deoxy-β-D-erythro -pentofuranosyl)-5- nitro-1H -indole;1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-nitro-1H-indole
CBNumber: CB8239006
Molecular Formula: C13H14N2O5
Formula Weight: 278.26
MOL File: 191421-10-0.mol

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1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE Property

Boiling point:: 572.5±50.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: -10 to -25°C
solubility: DMSO: 2mg/mL, clear
form: Solid
pka: 14.01±0.60(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3407
Product name: 5-NIDR
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $89.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3407
Product name: 5-NIDR
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $360
Updated: 2024/03/01

AK Scientific

Product number: 1303CW
Product name: (2R,3S,5R)-2-(Hydroxymethyl)-5-(5-nitroindol-1-yl)oxolan-3-ol
Packaging: 100mg
Price: $405
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CRB0006248
Product name: 1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-5-NITROINDOLE
Purity: 95.00%
Packaging: 5MG
Price: $495.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND10031
Product name: 1-(2-Deoxy-b-D-ribofuranosyl)-5-nitroindole
Packaging: 25mg
Price: $89.5
Updated: 2021/12/16

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1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE Chemical Properties,Usage,Production

Uses

5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole), an artificial nucleoside, exhibits the ability to inhibit the replication of DNA lesions generated by Temozolomide (HY-17364). 5-NIdR induces cancer cells apoptosis and arrests cell cycle at G0 phase. 5-NIdR enhances Temozolomide anti-tumor efficacy in murine glioblastoma model[1].

in vivo

5-NIdR (100 mg/kg; ip; for 5 consecutive days), together with Temozolomide (40 mg/kg), results complete tumor regression in a murine xenograft model of glioblastoma. Temozolomide alone only delayed tumor growth^[1].

References

[1] Choi JS, et al. Inhibition of Translesion DNA Synthesis as a Novel Therapeutic Strategy to Treat Brain Cancer. Cancer Res. 2018 Feb 15;78(4):1083-1096. DOI:10.1158/0008-5472.CAN-17-2464

1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE Suppliers

China 18 India 1 United Kingdom 3 United States 4 Global 26

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191421-10-0, 1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLERelated Search:

2'-DEOXYGUANOSINE5'-MONOPHOSPHATE,DISODIUM SALT(DGMP·2NA) 5-Nitroindole 1-(5-O-(DIMETHOXYTRITYL)-BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE 5-NITRO-1-INDOLYL-2'-DEOXYRIBOSE-5'-TRIPHOSPHATE LITHIUM SALT 1-METHYL-5-NITRO-1H-INDOLE 1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE

1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE

1-(2-Deoxy-b-D-ribofuranosyl)-5-nitroindole

5-Nitroindole 2'-deoxyribonucleoside

1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-nitro-1H-indole

1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole

2'-DEOXY-NITRO INDOLE NUCLEOSIDE

1-(b-D-2-Deoxyribofuranosyl)-5-nitroindole

5-NIdR

1H-Indole, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-nitro-

1-(2-Deoxy-β-D-erythro -pentofuranosyl)-5- nitro-1H -indole

191421-10-0