ChemicalBook > CAS DataBase List > 4-Hydroxypiperidine hydrochloride

4-Hydroxypiperidine hydrochloride

Product Name
4-Hydroxypiperidine hydrochloride
CAS No.
5382-17-2
Chemical Name
4-Hydroxypiperidine hydrochloride
Synonyms
4-PiperidinolHCl;piperidin-4-ol hcl;TIMTEC-BB SBB004192;4-Hydroxypiperidine HCl;4 HYDROXY PIPERADINE HCL;Piperidin-4-olhydrochlorid;4-PIPIRIDINOL HYDROCHLORIDE;4-PIPERIDINOL HYDROCHLORIDE;PIPERIDIN-4-OL HYDROCHLORIDE;2-FLUOROPHENYL HYDRAZINE BASE
CBNumber
CB1758834
Molecular Formula
C5H12ClNO
Formula Weight
137.61
MOL File
5382-17-2.mol
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4-Hydroxypiperidine hydrochloride Property

Melting point:
155-157 °C(lit.)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
methanol: soluble25mg/mL, clear, colorless
form 
powder to crystaline
color 
White to Orange to Green
Water Solubility 
very faint turbidity
BRN 
3908995
CAS DataBase Reference
5382-17-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
3
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
391468
Product name
4-Hydroxypiperidine hydrochloride
Purity
98%
Packaging
5g
Price
$61
Updated
2023/01/07
TCI Chemical
Product number
H0686
Product name
4-Hydroxypiperidine Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$118
Updated
2023/06/20
TRC
Product number
H952208
Product name
4-Hydroxypiperidine hydrochloride
Packaging
500mg
Price
$65
Updated
2021/12/16
TRC
Product number
H952208
Product name
4-Hydroxypiperidine hydrochloride
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
H952208
Product name
4-Hydroxypiperidine hydrochloride
Packaging
250mg
Price
$55
Updated
2021/12/16
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4-Hydroxypiperidine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

4-Hydroxypiperidine, HCl

Uses

4-Hydroxypiperidine hydrochloride is suitable for use in the Ugi-multi component reaction (MCR) to study the use of miniaturised-synthesis and Total Analysis System (mSYNTAS) in solution phase synthesis and on-line analysis of Ugi-MCRs. It may be used in the synthesis of acetic acid-piperidine-4-yl ester.

General Description

4-Hydroxypiperidine hydrochloride is a piperidine derivative. The synthesis of 4-hydroxypiperidine has been reported. 4-Hydroxypiperidine participates in the synthesis of 4-(4′-hydroxypiperidino)-4-phenylcyclohexanol and 1-(4-hydroxypiperidino)cyclohexanecarbonitrile. 4-Hydroxypiperidine is the starting material for the synthesis of Sibrafiban and Lamifiban, two non-peptidefibrinogen receptor.

Synthesis

109384-19-2

5382-17-2

The general procedure for the synthesis of 4-hydroxypiperidine hydrochloride from N-Boc-4-hydroxypiperidine was as follows: tert-butyl 4-hydroxypiperidine-1-carboxylate (5 g, 24.84 mmol, 1.00 eq.) was mixed with a saturated HCl solution dissolved in 30 mL of 1,4-dioxane, and the reaction was stirred for 2 h at room temperature. Upon completion of the reaction, the mixture was concentrated in vacuum to afford 4-hydroxypiperidine hydrochloride (3.4 g, 99% yield) as an off-white solid.

References

[1] Patent: WO2015/52264, 2015, A1. Location in patent: Paragraph 0918; 0919
[2] Patent: WO2017/153520, 2017, A1. Location in patent: Page/Page column 50
[3] Patent: WO2016/34673, 2016, A1. Location in patent: Page/Page column 120

4-Hydroxypiperidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxypiperidine hydrochloride Suppliers

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View Lastest Price from 4-Hydroxypiperidine hydrochloride manufacturers

Career Henan Chemical Co
Product
4-Hydroxypiperidine hydrochloride 5382-17-2
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-24

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