ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE
- Product Name
- ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE
- CAS No.
- 40019-21-4
- Chemical Name
- ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE
- Synonyms
- ethyl 3-oxadiazole-ethyl 3-oxadiazole-;ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE;3-Methyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester;1,2,4-Oxadiazole-5-carboxylic acid, 3-methyl-, ethyl ester
- CBNumber
- CB1764884
- Molecular Formula
- C6H8N2O3
- Formula Weight
- 156.14
- MOL File
- 40019-21-4.mol
ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE Property
- Boiling point:
- 238.0±23.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -2.95±0.30(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E939638
- Product name
- Ethyl3-Methyl-1,2,4-oxadiazole-5-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CHM0379436
- Product name
- ETHYL-3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.18
- Updated
- 2021/12/16
- Product number
- 059158
- Product name
- 3-Methyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1005
- Updated
- 2021/12/16
- Product number
- 5295AB
- Product name
- Ethyl3-methyl-1,2,4-oxadiazole-5-carboxylate
- Packaging
- 25g
- Price
- $1563
- Updated
- 2021/12/16
- Product number
- 059158
- Product name
- 3-Methyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $227
- Updated
- 2021/12/16
ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
4755-77-5
22059-22-9
40019-21-4
General procedure for the synthesis of ethyl 3-methyl-1,2,4-oxadiazole-5-carboxylate from ethyl oxalyl chloride monoethyl ester and N'-hydroxyacetimidamide: At room temperature, (E)-N'-hydroxyacetimidamide (2.0 mmol, 1.0 g, 13.50 mmol, 1 equiv.) and pyridine (4.35 mL, 54.0 mmol, 4 equiv.) were dissolved in anhydrous dichloromethane ( 40 mL) and acetyl chloride (2.4 g, 18.0 mmol, 1.3 equiv) was added slowly. The reaction mixture was stirred under reflux conditions for 14 hours. After completion of the reaction, it was cooled to room temperature and the reaction was quenched with saturated ammonium chloride solution (30 mL). The aqueous phase was extracted with dichloromethane (2 x 50 mL). The organic phases were combined, washed with saturated sodium bicarbonate solution (50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford ethyl 3-methyl-1,2,4-oxadiazole-5-carboxylate (2.2 mmol, 1.32 g, 8.45 mmol, 63% yield) as a yellow oil, which was used directly in the next step of the reaction.LCMS analysis showed a purity of 92%, retention time was 2.0 min, (M + H)+: 157.
References
[1] Patent: WO2013/50424, 2013, A1. Location in patent: Page/Page column 116
ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE manufacturers
- Product
- ethyl 3-?oxadiazole-? 40019-21-4
- Price
- US $1.00-100.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 300KG
- Release date
- 2024-08-19