ChemicalBook > CAS DataBase List > ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE

ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE

Product Name
ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE
CAS No.
40019-21-4
Chemical Name
ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE
Synonyms
ethyl 3-​oxadiazole-​ethyl 3-oxadiazole-;ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE;3-Methyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester;1,2,4-Oxadiazole-5-carboxylic acid, 3-methyl-, ethyl ester
CBNumber
CB1764884
Molecular Formula
C6H8N2O3
Formula Weight
156.14
MOL File
40019-21-4.mol
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ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE Property

Boiling point:
238.0±23.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
-2.95±0.30(Predicted)
Appearance
Colorless to light yellow Liquid
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Safety

HazardClass 
IRRITANT
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E939638
Product name
Ethyl3-Methyl-1,2,4-oxadiazole-5-carboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
059158
Product name
3-Methyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester
Purity
95+%
Packaging
1g
Price
$227
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0379436
Product name
ETHYL-3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$503.18
Updated
2021/12/16
Matrix Scientific
Product number
059158
Product name
3-Methyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester
Purity
95+%
Packaging
5g
Price
$1005
Updated
2021/12/16
AK Scientific
Product number
5295AB
Product name
Ethyl3-methyl-1,2,4-oxadiazole-5-carboxylate
Packaging
25g
Price
$1563
Updated
2021/12/16
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ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

4755-77-5

22059-22-9

40019-21-4

General procedure for the synthesis of ethyl 3-methyl-1,2,4-oxadiazole-5-carboxylate from ethyl oxalyl chloride monoethyl ester and N'-hydroxyacetimidamide: At room temperature, (E)-N'-hydroxyacetimidamide (2.0 mmol, 1.0 g, 13.50 mmol, 1 equiv.) and pyridine (4.35 mL, 54.0 mmol, 4 equiv.) were dissolved in anhydrous dichloromethane ( 40 mL) and acetyl chloride (2.4 g, 18.0 mmol, 1.3 equiv) was added slowly. The reaction mixture was stirred under reflux conditions for 14 hours. After completion of the reaction, it was cooled to room temperature and the reaction was quenched with saturated ammonium chloride solution (30 mL). The aqueous phase was extracted with dichloromethane (2 x 50 mL). The organic phases were combined, washed with saturated sodium bicarbonate solution (50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford ethyl 3-methyl-1,2,4-oxadiazole-5-carboxylate (2.2 mmol, 1.32 g, 8.45 mmol, 63% yield) as a yellow oil, which was used directly in the next step of the reaction.LCMS analysis showed a purity of 92%, retention time was 2.0 min, (M + H)+: 157.

References

[1] Patent: WO2013/50424, 2013, A1. Location in patent: Page/Page column 116

ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE Suppliers

China 52 India 2 United Kingdom 1 United States 8 Global 63
Accela ChemBio Inc.
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+1-858-6993322
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Advanced Chemical Intermediates Ltd.
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Matrix Scientific
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View Lastest Price from ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
ethyl 3-?oxadiazole-? 40019-21-4
Price
US $1.00-100.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
300KG
Release date
2024-08-19

40019-21-4, ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATERelated Search:

ETHYL 3-(2-CHLOROPHENOXY)METHYL-1,2,4-OXADIAZOLE-5 CARBOXYLATE ETHYL 3-(3,4-DIMETHOXYPHENYL)-1,2,4-OXADIAZOLE-5-CARBOXYLATE ETHYL 3-(2-THIENYL)-1,2,4-OXADIAZOLE-5-CARBOXYLATE ETHYL 3-[5-(CHLOROSULFONYL)-2-THIENYL]-1,2,4-OXADIAZOLE-5-CARBOXYLATE ETHYL 3-PHENYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE ETHYL 3-(3-CHLOROPHENYL)-1,2,4-OXADIAZOLE-5-CARBOXYLATE 3-(4-NITRO-PHENYL)-[1,2,4]OXADIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 3-(4-CHLORO-PHENYL)-[1,2,4]OXADIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER ETHYL 3-(3-METHOXYPHENYL)-1,2,4-OXADIAZOLE-5-CARBOXYLATE 1,2,4-OXADIAZOLE-5-CARBOXYLIC ACID, 3-[(5-METHYL-3-NITRO-1H-PYRAZOL-1-YL)METHYL]-, ETHYL ESTER ETHYL 3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE-5-CARBOXYLATE 1,2,4-OXADIAZOLE-5-CARBOXYLIC ACID, 3-[(4-BROMO-3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHYL]-, ETHYL ESTER 1,2,4-OXADIAZOLE-5-CARBOXYLIC ACID, 3-[(4-IODO-1H-PYRAZOL-1-YL)METHYL]-, ETHYL ESTER 3-P-TOLYL-[1,2,4]OXADIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER ETHYL 3-([(4-CHLOROPHENYL)SULFONYL]METHYL)-1,2,4-OXADIAZOLE-5-CARBOXYLATE 1,2,4-OXADIAZOLE-5-CARBOXYLIC ACID, 3-[(PHENYLSULFONYL)METHYL]-, ETHYL ESTER 1,2,4-OXADIAZOLE-5-CARBOXYLIC ACID, 3-[4-(TRIFLUOROMETHYL)PHENYL]-, ETHYL ESTER

  • ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE
  • 3-Methyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester
  • 1,2,4-Oxadiazole-5-carboxylic acid, 3-methyl-, ethyl ester
  • ethyl 3-&#8203
  • oxadiazole-&#8203
  • ethyl 3-oxadiazole-
  • 40019-21-4