Thiodiglycolic Anhydride
- Product Name
- Thiodiglycolic Anhydride
- CAS No.
- 3261-87-8
- Chemical Name
- Thiodiglycolic Anhydride
- Synonyms
- 1,4-OXATHIANE-2,6-DIONE;1,4-Oxathiane-2,6-dione (Thiodiglycolic anhydride);NSC 147625;THIODIGLYCOLIC ANHYDRIDE;Thiodilycolic Anhydride;2,2'-Thiobisacetic anhydride;2,2'-THIODIACETIC ACID ANHYDRIDE;1-Oxa-4-thia-cyclohexan-2,6-dione;1,4-OXATHIANE-2,6-DIONE
THIODIGLYCOLIC ANHYDRIDE;1,4-Oxathiane-2,6-dione~2,2-Thiodiacetic acid anhydride - CBNumber
- CB1765467
- Molecular Formula
- C4H4O3S
- Formula Weight
- 132.14
- MOL File
- 3261-87-8.mol
Thiodiglycolic Anhydride Property
- Melting point:
- 94 °C
- Boiling point:
- 158-159 °C(Press: 12 Torr)
- Density
- 1.468±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO, Methanol (Sparingly)
- form
- Solid
- color
- White to Off-White
- Sensitive
- Moisture Sensitive
- BRN
- 112528
- InChI
- InChI=1S/C4H4O3S/c5-3-1-8-2-4(6)7-3/h1-2H2
- InChIKey
- RIIUAPMWDSRBSH-UHFFFAOYSA-N
- SMILES
- O1C(=O)CSCC1=O
- CAS DataBase Reference
- 3261-87-8(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xn
- Risk Statements
- 20/21/22-34-22
- Safety Statements
- 26-36/37/39
- RIDADR
- 3261
- Hazard Note
- Corrosive
- PackingGroup
- III
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 467527
- Product name
- Thiodiglycolic Anhydride
- Packaging
- 5g
- Price
- $355
- Updated
- 2021/12/16
- Product number
- T344525
- Product name
- ThiodiglycolicAnhydride
- Packaging
- 5g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 4562BA
- Product name
- 1,4-Oxathiane-2,6-dione
- Packaging
- 100g
- Price
- $112
- Updated
- 2021/12/16
- Product number
- OR28488
- Product name
- 1,4-Oxathiane-2,6-dione
- Packaging
- 5g
- Price
- $44
- Updated
- 2021/12/16
- Product number
- 6H66-1-00
- Product name
- 1,4-Oxathiane-2,6-dione
- Packaging
- 5G
- Price
- $48
- Updated
- 2021/12/16
Thiodiglycolic Anhydride Chemical Properties,Usage,Production
Chemical Properties
White needle-shaped crystal
Uses
Thiodiglycolic Anhydride is used as a reagent in the synthesis of positively charged compounds as SERT inhibitors useful in the treatment of central nervous system (CNS) disorders.
Synthesis
123-93-3
3261-87-8
3.0 g of 2,2'-thiodiacetic acid was accurately weighed in a 50 mL round bottom flask. To the flask was added 15 mL of acetic anhydride as reaction solvent. The reaction mixture was heated to 65 °C and kept at reflux for 4 hours. Upon completion of the reaction, the excess acetic anhydride and the by-product acetic acid were removed by distillation under reduced pressure. Subsequently, an appropriate amount of ether was added to the residue and the evaporation operation was repeated 2-3 times to purify the product. The final product was obtained as 2,2'-thiodiacetic anhydride in the form of a white solid powder and the product was dried at 40 °C overnight in 98.7% yield.
References
[1] Patent: CN108245683, 2018, A. Location in patent: Paragraph 0051; 0053
[2] Organic Letters, 2015, vol. 17, # 15, p. 3930 - 3933
[3] Tetrahedron Letters, 2017, vol. 58, # 32, p. 3160 - 3163
[4] Tetrahedron Letters, 2002, vol. 43, # 8, p. 1519 - 1522
[5] Tetrahedron Letters, 2017, vol. 58, # 37, p. 3672 - 3677
Thiodiglycolic Anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Thiodiglycolic Anhydride manufacturers
- Product
- THIODIGLYCOLIC ANHYDRIDE 3261-87-8
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-20
- Product
- THIODIGLYCOLIC ANHYDRIDE 3261-87-8
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-10