ChemicalBook > CAS DataBase List > 1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE

1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE

Product Name
1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE
CAS No.
5308-63-4
Chemical Name
1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE
Synonyms
2-ACETYL-5-METHYLPYRIDINE;1-(5-Methyl-2-pyridinyl)-Ethanone;1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE;Ethanone, 1-(5-methyl-2-pyridinyl)-;1-(5-methylpyridin-2-yl)ethan-1-one;1-(5-methyl-2-pyridinyl)ethanone(SALTDATA: HCl);1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE ISO 9001：2015 REACH
CBNumber
CB1766141
Molecular Formula
C8H9NO
Formula Weight
135.16
MOL File
5308-63-4.mol
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1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE Property

Boiling point:
105 °C(Press: 13 Torr)
Density 
1.036±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
3.29±0.10(Predicted)
Appearance
Colorless to light yellow Liquid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M321570
Product name
1-(5-Methylpyridin-2-yl)ethanone
Packaging
500mg
Price
$155
Updated
2021/12/16
AK Scientific
Product number
7521AB
Product name
1-(5-Methylpyridin-2-yl)ethanone
Packaging
5g
Price
$468
Updated
2021/12/16
Matrix Scientific
Product number
189236
Product name
1-(5-Methylpyridin-2-yl)ethanone
Packaging
5g
Price
$540
Updated
2021/12/16
AK Scientific
Product number
7521AB
Product name
1-(5-Methylpyridin-2-yl)ethanone
Packaging
250mg
Price
$104
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-575
Product name
2-Acetyl-5-methylpyridine
Purity
95.0%
Packaging
1g
Price
$112
Updated
2021/12/16
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1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE Chemical Properties,Usage,Production

Definition

ChEBI: 2-Acetyl-5-methylpyridine is an aromatic ketone.

Synthesis

3510-66-5

127-19-5

5308-63-4

General procedure for the synthesis of 2-acetyl-5-methylpyridine from 2-bromo-5-methylpyridine and N,N-dimethylacetamide: [Reference Example 35] 5-(5-methyl-2-pyridinyl)-1-(2-pyridinyl)-1H-pyrazole-3-carboxylic acid; [show image] 1) 1-(5-methyl-2-pyridinyl)ethanone; At -78 °C, over 5 min n-butyllithium (1.58 M hexane solution, 24 ml) was added dropwise to a solution of diethyl ether (100 ml) of 2-bromo-5-methylpyridine (5.0 g) and the mixture was stirred for 5 min. Maintaining the same temperature, N,N-dimethylacetamide (3.5 ml) was added to the reaction solution and stirring was continued for 2 hours. After completion of the reaction, water and ethyl acetate were added to the reaction solution and the organic and aqueous phases were separated. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate) to afford 1-(5-methyl-2-pyridinyl)ethanone (3.43 g, 87% yield) as an oily product.1H-NMR (400 MHz, CDCl3) δ: 2.42 (3H, s), 2.71 (3H, s), 7.62 (1H, dd, J = 1.59, 7.93 Hz), 7.94 (1H, d, J = 7.93 Hz), 8.50 (1H, s).

References

[1] Inorganic Chemistry, 2018,
[2] Patent: EP1698626, 2006, A1. Location in patent: Page/Page column 48
[3] Patent: EP1762568, 2007, A1. Location in patent: Page/Page column 30
[4] Patent: EP1785418, 2007, A1. Location in patent: Page/Page column 38
[5] Chemistry - A European Journal, 2008, vol. 14, # 2, p. 570 - 581

1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE Suppliers

Canada 1 China 87 India 1 Switzerland 1 United Kingdom 1 United States 17 USA 1 Global 109
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View Lastest Price from 1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE 5308-63-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-26
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
2-Acetyl-5-methylpyridine 5308-63-4
Price
US $4.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-09-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
1-(5-Methylpyridin-2-yl)ethanone 5308-63-4
Price
US $4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-11-26

5308-63-4, 1-(5-METHYL-PYRIDIN-2-YL)-ETHANONERelated Search:

2-ACETYL-6-METHYLPYRIDINE 1-(6-METHYL-PYRIDIN-2-YL)-ETHANONE,1-(6-METHYL-PYRIDIN-2-YL)-ETHANONE 1-(4-METHYL-PYRIDIN-2-YL)-ETHANONE 6-ACETYL-2-MERCAPTONICOTINONITRILE (4-CHLOROPHENYL)[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE (4-CHLOROPHENYL)[3-(1-PYRROLIDINYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE 2-BROMO-1-[6-(4-FLUORO-PHENYL)-2-METHYL-PYRIDIN-3-YL]-ETHANONE (4-CHLOROPHENYL)[3-(4-PHENYLPIPERAZINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE [3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL][3-(TRIFLUOROMETHYL)PHENYL]METHANONE [3-MORPHOLINO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](PHENYL)METHANONE [3-(2,4-DICHLOROPHENOXY)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](2,4-DICHLOROPHENYL)METHANONE [3-(TRIFLUOROMETHYL)PHENYL](5-(TRIFLUOROMETHYL)-2-[3-(TRIFLUOROMETHYL)BENZOYL]-3-PYRIDINYL)METHANONE [3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](4-METHOXYPHENYL)METHANONE [3-(1-AZEPANYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](4-CHLOROPHENYL)METHANONE [3-MORPHOLINO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](4-NITROPHENYL)METHANONE [3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](3-METHOXYPHENYL)METHANONE (2,4-DICHLOROPHENYL)[3-PHENOXY-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE [3-(DIMETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](4-NITROPHENYL)METHANONE (4-CHLOROPHENYL)[3-(DIMETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE

  • 2-ACETYL-5-METHYLPYRIDINE
  • 1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE
  • Ethanone, 1-(5-methyl-2-pyridinyl)-
  • 1-(5-methyl-2-pyridinyl)ethanone(SALTDATA: HCl)
  • 1-(5-Methyl-2-pyridinyl)-Ethanone
  • 1-(5-METHYL-PYRIDIN-2-YL)-ETHANONE ISO 9001：2015 REACH
  • 1-(5-methylpyridin-2-yl)ethan-1-one
  • 5308-63-4
  • Pyridines