2-Acetyl-4-methylpyridine

Product Name: 2-Acetyl-4-methylpyridine
CAS No.: 59576-26-0
Chemical Name: 2-Acetyl-4-methylpyridine
Synonyms: 1-(4-methylpyridin-2-yl)ethan-1-one;2-Acetyl-4-picoline;2-Acetyl-4-Methylpyrdine;2-ACETYL-4-METHYLPYRIDIN;2-ACETYL-4-METHYLPYRIDINE;2-Acetyl-4-Methylpiridine;4-methyl-2-acetylpyridine;2-Acetyl-4-methylpyridine >1-(4-Methyl-2-pyridinyl)ethanone;1-(4-METHYL-PYRIDIN-2-YL)-ETHANONE
CBNumber: CB7680395
Molecular Formula: C8H9NO
Formula Weight: 135.16
MOL File: 59576-26-0.mol

More

Less

2-Acetyl-4-methylpyridine Property

Melting point:: 30-34 °C(lit.)
Boiling point:: 95-97 °C(Press: 15 Torr)
Density: 1.036±0.06 g/cm3(Predicted)
Flash point:: 203 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to lump
pka: 3.82±0.10(Predicted)
color: White to Gray to Brown
InChI: InChI=1S/C8H9NO/c1-6-3-4-9-8(5-6)7(2)10/h3-5H,1-2H3
InChIKey: HRVQMQWVGKYDCF-UHFFFAOYSA-N
SMILES: C(=O)(C1=NC=CC(C)=C1)C
CAS DataBase Reference: 59576-26-0(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 499234
Product name: 2-Acetyl-4-methylpyridine
Purity: 98%
Packaging: 1g
Price: $46.65
Updated: 2025/07/31

TCI Chemical

Product number: A2338
Product name: 2-Acetyl-4-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $86
Updated: 2025/07/31

TCI Chemical

Product number: A2338
Product name: 2-Acetyl-4-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $293
Updated: 2025/07/31

TRC

Product number: A189013
Product name: 2-Acetyl-4-methylpyridine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: A189013
Product name: 2-Acetyl-4-methylpyridine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

More

Less

2-Acetyl-4-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

Crystals

Uses

2-Acetyl-4-methylpyridine may be used in the synthesis of:

3,5-bis(4,4"-dimethyl-2,2′:6′,2′′-terpyridin-4′-yl)-1-bromobenzene
1,3-bis(4,4"-dimethyl-2,2′:6′,2′′-terpyridin-4′-yl)-5-methylbenzene
2-(3′,3′-bis(ethylthio)-1′-oxoprop-2′-en-1′-yl)-4-methylpyridine
2-(3′-(N,N-dimethylamino)-1′-oxoprop-2′-en-1′-yl)-4-methylpyridine

Definition

ChEBI: 2-Acetyl-4-methylpyridine is an aromatic ketone.

General Description

2-Acetyl-4-methylpyridine is a substituted pyridine that can be prepared from 2-bromo-4-methylpyridine.

Synthesis

1620-76-4

917-64-6

59576-26-0

GENERAL STEPS: To a stirred mixed solution of 2-cyano-4-methylpyridine (31.19 g, 229 mmol) in anhydrous ethyl ether (300 mL) and anhydrous ethyl ether (230 mL) was slowly added dropwise to an ethyl ether solution of 2M methylmagnesium iodide (149.0 mL, 298 mmol) under nitrogen protection for a controlled time period of 1 hr. The reaction mixture was gradually warmed up to room temperature and continued to stir under nitrogen protection for 1 hour, followed by cooling to 0 °C. An aqueous ammonium chloride solution (120 mL) was slowly added dropwise to the reaction mixture at 0 °C, then the mixture was warmed up to room temperature and stirred for 1 hour. The aqueous layer was separated, the organic layer was washed with water, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel, hexane/ethyl acetate=8:1) to give 16.20 g of 1-(4-methylpyridin-2-yl)ethanone (41) as a yellow oil in 52% yield. The structure of the product was confirmed by 1H NMR (CDCl3, 270 MHz): δ8.54 (1H, d, J=4.9 Hz), 7.88-7.87 (1H, m), 7.30-7.27 (1H, m), 2.72 (3H, s), 2.43 (3H, m).

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 50, p. 179 - 195
[2] Journal of the American Chemical Society, 1956, vol. 78, p. 5842

2-Acetyl-4-methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-Acetyl-4-methylpyridine Suppliers

Americas 1 Canada 1 China 199 Europe 1 France 1 Germany 4 India 28 Japan 2 Switzerland 2 The Netherlands 2 United Kingdom 8 United States 36 Global 285

Jinan Asia Pharma Tech Co.,Ltd.

Tel: 0531-67809944 15550032919
Email: sales8@china-aptc.com
Country: China
ProdList: 48
Advantage: 58

Suzhou Uni-Inno Biomedical Co., Ltd

Tel: 13222205691
Email: 279078865@qq.com
Country: China
ProdList: 500
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

More

Less

View Lastest Price from 2-Acetyl-4-methylpyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Acetyl-4-methylpyridine 59576-26-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Acetyl-4-methylpyridine 59576-26-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-02-12

Dideu Industries Group Limited

Product: 2-Acetyl-4-methylpyridine 59576-26-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-26

59576-26-0, 2-Acetyl-4-methylpyridineRelated Search:

2-Chloro-3-cyanopyridine 2,6-Lutidine 2,4,6-Collidine 4-Methylpyridine Acetyl chloride Azamethiphos 2-Acetylpyridine Acetyl coenzyme A sodium salt Acetylacetone L-PICEIN 2-Chloro-5-chloromethylpyridine Pyrroloquinoline quinone 3-ACETYL-6-METHYLPYRIDINE,5-ACETYL-2-METHYLPYRIDINE 2-ACETYL-6-METHYLPYRIDINE,2-ACETYL-6-METHYLPYRIDINE 1-(6-METHYL-PYRIDIN-2-YL)-ETHANONE,6-Acetyl-2-methylpyridine 3-(ACETAMIDOMETHYL)PYRIDINE 4-ACETOXYMETHYLPYRIDINE 3-Acetyl-2-methylpyridine Methyl 2-acetylisonicotinate

2-ACETYL-4-METHYLPYRIDINE

1-(4-METHYL-PYRIDIN-2-YL)-ETHANONE

2-Acetyl-4-picoline

2-ACETYL-4-METHYLPYRIDIN

4-methyl-2-acetylpyridine

2-Acetyl-4-Methylpiridine

1-(4-methylpyridin-2-yl)ethan-1-one

2-Acetyl-4-methylpyridine &gt

Ethanone, 1-(4-methyl-2-pyridinyl)-

2-Acetyl-4-methylpyridine ISO 9001：2015 REACH

2-Acetyl-4-Methylpyrdine

1-(4-Methyl-2-pyridinyl)ethanone

59576-26-0

C7 and C8

Building Blocks

Pyridines

Heterocyclic Building Blocks

Building Blocks

C8 to C9

Chemical Synthesis

Heterocyclic Building Blocks

C7 and C8

Heterocyclic Building Blocks

Pyridine

Heterocyclic Compounds

Pyridines

OLED