2-Acetyl-4-methylpyridine
- Product Name
- 2-Acetyl-4-methylpyridine
- CAS No.
- 59576-26-0
- Chemical Name
- 2-Acetyl-4-methylpyridine
- Synonyms
- 1-(4-methylpyridin-2-yl)ethan-1-one;2-Acetyl-4-picoline;2-Acetyl-4-Methylpyrdine;2-ACETYL-4-METHYLPYRIDIN;2-ACETYL-4-METHYLPYRIDINE;2-Acetyl-4-Methylpiridine;4-methyl-2-acetylpyridine;2-Acetyl-4-methylpyridine >1-(4-Methyl-2-pyridinyl)ethanone;1-(4-METHYL-PYRIDIN-2-YL)-ETHANONE
- CBNumber
- CB7680395
- Molecular Formula
- C8H9NO
- Formula Weight
- 135.16
- MOL File
- 59576-26-0.mol
2-Acetyl-4-methylpyridine Property
- Melting point:
- 30-34 °C(lit.)
- Boiling point:
- 95-97 °C(Press: 15 Torr)
- Density
- 1.036±0.06 g/cm3(Predicted)
- Flash point:
- 203 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to lump
- pka
- 3.82±0.10(Predicted)
- color
- White to Gray to Brown
- InChI
- InChI=1S/C8H9NO/c1-6-3-4-9-8(5-6)7(2)10/h3-5H,1-2H3
- InChIKey
- HRVQMQWVGKYDCF-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=NC=CC(C)=C1)C
- CAS DataBase Reference
- 59576-26-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 499234
- Product name
- 2-Acetyl-4-methylpyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $46.65
- Updated
- 2025/07/31
- Product number
- A2338
- Product name
- 2-Acetyl-4-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $86
- Updated
- 2025/07/31
- Product number
- A2338
- Product name
- 2-Acetyl-4-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $293
- Updated
- 2025/07/31
- Product number
- A189013
- Product name
- 2-Acetyl-4-methylpyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- A189013
- Product name
- 2-Acetyl-4-methylpyridine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
2-Acetyl-4-methylpyridine Chemical Properties,Usage,Production
Chemical Properties
Crystals
Uses
2-Acetyl-4-methylpyridine may be used in the synthesis of:
- 3,5-bis(4,4"-dimethyl-2,2′:6′,2′′-terpyridin-4′-yl)-1-bromobenzene
- 1,3-bis(4,4"-dimethyl-2,2′:6′,2′′-terpyridin-4′-yl)-5-methylbenzene
- 2-(3′,3′-bis(ethylthio)-1′-oxoprop-2′-en-1′-yl)-4-methylpyridine
- 2-(3′-(N,N-dimethylamino)-1′-oxoprop-2′-en-1′-yl)-4-methylpyridine
Definition
ChEBI: 2-Acetyl-4-methylpyridine is an aromatic ketone.
General Description
2-Acetyl-4-methylpyridine is a substituted pyridine that can be prepared from 2-bromo-4-methylpyridine.
Synthesis
1620-76-4
917-64-6
59576-26-0
GENERAL STEPS: To a stirred mixed solution of 2-cyano-4-methylpyridine (31.19 g, 229 mmol) in anhydrous ethyl ether (300 mL) and anhydrous ethyl ether (230 mL) was slowly added dropwise to an ethyl ether solution of 2M methylmagnesium iodide (149.0 mL, 298 mmol) under nitrogen protection for a controlled time period of 1 hr. The reaction mixture was gradually warmed up to room temperature and continued to stir under nitrogen protection for 1 hour, followed by cooling to 0 °C. An aqueous ammonium chloride solution (120 mL) was slowly added dropwise to the reaction mixture at 0 °C, then the mixture was warmed up to room temperature and stirred for 1 hour. The aqueous layer was separated, the organic layer was washed with water, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel, hexane/ethyl acetate=8:1) to give 16.20 g of 1-(4-methylpyridin-2-yl)ethanone (41) as a yellow oil in 52% yield. The structure of the product was confirmed by 1H NMR (CDCl3, 270 MHz): δ8.54 (1H, d, J=4.9 Hz), 7.88-7.87 (1H, m), 7.30-7.27 (1H, m), 2.72 (3H, s), 2.43 (3H, m).
References
[1] European Journal of Medicinal Chemistry, 2012, vol. 50, p. 179 - 195
[2] Journal of the American Chemical Society, 1956, vol. 78, p. 5842
2-Acetyl-4-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Acetyl-4-methylpyridine Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from 2-Acetyl-4-methylpyridine manufacturers
- Product
- 2-Acetyl-4-methylpyridine 59576-26-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 2-Acetyl-4-methylpyridine 59576-26-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-12
- Product
- 2-Acetyl-4-methylpyridine 59576-26-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-26