1-(2-Methylpyridin-3-yl)ethanone
- Product Name
- 1-(2-Methylpyridin-3-yl)ethanone
- CAS No.
- 1721-12-6
- Chemical Name
- 1-(2-Methylpyridin-3-yl)ethanone
- Synonyms
- 1-(2-Methylpyridin-3-yl)ethan-1-one;3-Acetyl-2-picoline;1-(2-Methylpyridin-3-yl);3-Acetyl-2-methylpyridine;1-(2-Methyl-3-pyridyl)ethanone;1-(2-Methylpyridin-3-yl)ethanone;1-(2-Methyl-3-pyridinyl)-Ethanone;Ethanone, 1-(2-methyl-3-pyridinyl)-;1-(2-methylpyridin-3-yl)ethane-1-one
- CBNumber
- CB42462112
- Molecular Formula
- C8H9NO
- Formula Weight
- 135.16
- MOL File
- 1721-12-6.mol
1-(2-Methylpyridin-3-yl)ethanone Property
- Melting point:
- 30-31 °C
- Boiling point:
- 226 ºC
- Density
- 1.036
- Flash point:
- 96 ºC
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.15±0.10(Predicted)
- Appearance
- Light yellow to brown Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y7806
- Product name
- 1-(2-Methylpyridin-3-yl)ethanone
- Packaging
- 1g
- Price
- $484
- Updated
- 2021/12/16
- Product number
- CHM0068863
- Product name
- ETHANONE, 1-(2-METHYL-3-PYRIDINYL)-
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.75
- Updated
- 2021/12/16
- Product number
- Y7806
- Product name
- 1-(2-Methylpyridin-3-yl)ethanone
- Packaging
- 100mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- AA10-1647
- Product name
- 1-(2-Methyl-pyridin-3-yl)-ethanone
- Purity
- 95%
- Packaging
- 1g
- Price
- $295
- Updated
- 2021/12/16
- Product number
- CM132068
- Product name
- 1-(2-methylpyridin-3-yl)ethan-1-one
- Purity
- 98%
- Packaging
- 1g
- Price
- $308
- Updated
- 2021/12/16
1-(2-Methylpyridin-3-yl)ethanone Chemical Properties,Usage,Production
Synthesis Reference(s)
The Journal of Organic Chemistry, 43, p. 324, 1978 DOI: 10.1021/jo00396a032
Synthesis
3430-16-8
97674-02-7
1721-12-6
The following reagents were added sequentially to the microwave reaction tube: 469.80 μL (4.07 mmol) of 3-bromo-5-methylpyridine dissolved in 20 mL of H2O/DMF (1:3, v/v), 2.03 mL (5.70 mmol) of tributyl(1-ethoxyethenyl)tin, 57.12 mg (81.38 μmol) of chlorinated bis(triphenylphosphine)co-palladium (II), 1.12 g (8.14 mmol) potassium carbonate. The reaction mixture was concentrated to dryness under reduced pressure after microwave radiation at 110 °C for 1 hour. The residue was dissolved in water and extracted with ethyl acetate. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated to dryness under reduced pressure. The residue was dissolved in a mixture of 6 mL of methanol and 1 mL of 1N hydrochloric acid and stirred overnight at room temperature. The reaction mixture was concentrated to dryness under reduced pressure and the residue was dissolved in saturated aqueous sodium bicarbonate solution and extracted with ethyl acetate. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated to dryness under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 50/50 ethyl acetate/heptane) to give 160 mg of 1-(5-methylpyridin-3-yl)ethanone. The product characterization data were as follows: LC/MS (Method G): ESI+ [M+H]+: m/z 136, retention time (tr) = 0.38 min. 1H NMR (300 MHz, DMSO-d6, δ, ppm): 2.58 (s, 3H), 2.61 (s, 3H), 7.38 (m, 1H), 8.20 (m, 1H). 8.57 (m, 1H).
References
[1] Patent: WO2013/190123, 2013, A1. Location in patent: Page/Page column 62
[2] Patent: US2015/183804, 2015, A1. Location in patent: Paragraph 0618; 0619; 0620; 0621
1-(2-Methylpyridin-3-yl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(2-Methylpyridin-3-yl)ethanone manufacturers
- Product
- 1-(2-Methylpyridin-3-yl)ethanone 1721-12-6
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2019-12-27