ChemicalBook > CAS DataBase List > 16,16-DIMETHYL PROSTAGLANDIN E1

16,16-DIMETHYL PROSTAGLANDIN E1

Product Name
16,16-DIMETHYL PROSTAGLANDIN E1
CAS No.
41692-15-3
Chemical Name
16,16-DIMETHYL PROSTAGLANDIN E1
Synonyms
16,16-dimethyl PGE1;RQOFITYRYPQNLL-ZWSAOQBFSA-N;16,16-dimethylprostaglandin E;16,16-DIMETHYL PROSTAGLANDIN E1;9-oxo-11α,15R-dihydroxy-16,16-dimethyl-prost-13E-en-1-oic acid;9-OXO-11ALPHA,15R-DIHYDROXY-16,16-DIMETHYL-PROST-13E-EN-1-OIC ACID;Prost-13-en-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (11α,13E,15R)-;Prost-13-en-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (11alpha,13E,15R)-
CBNumber
CB1767779
Molecular Formula
C22H38O5
Formula Weight
382.53
MOL File
41692-15-3.mol
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16,16-DIMETHYL PROSTAGLANDIN E1 Property

storage temp. 
Store at -20°C
solubility 
DMF: >100 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1.6 mg/ml
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13750
Product name
16,16-dimethyl Prostaglandin E1
Purity
≥98%
Packaging
1mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
13750
Product name
16,16-dimethyl Prostaglandin E1
Purity
≥98%
Packaging
5mg
Price
$324
Updated
2024/03/01
Cayman Chemical
Product number
13750
Product name
16,16-dimethyl Prostaglandin E1
Purity
≥98%
Packaging
10mg
Price
$575
Updated
2024/03/01
AK Scientific
Product number
1251AH
Product name
16,16-DimethylprostaglandinE1
Packaging
5mg
Price
$459
Updated
2021/12/16
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16,16-DIMETHYL PROSTAGLANDIN E1 Chemical Properties,Usage,Production

Description

16,16-dimethyl PGE1 is a metabolically stable synthetic analog of PGE1. It induces human vascular smooth muscle contractions in vitro. It is 2, 3, and 6 times more potent than PGF2α in contracting tracheal, bronchial, and bronchiolar smooth muscle, respectively.1

Uses

16,16-Dimethylprostaglandin E1 (16,16-dimethyl-PGE1) is a PGE1 (HY-B0131) analog, induces bronchoconstrict and vascular smooth muscle contractions and suppresses the indomethacin induced cellular elongation[1][2][3].

Definition

ChEBI: 16,16-dimethyl-PGE1 is a prostanoid.

in vivo

16,16-Dimethylprostaglandin E1 (1 μg/kg?min for 30 min) accelerates blood pressure and heart rate recovery rate, increases catecholamine turnover, enhances levels of epinephrine and norepinephrine in plasma following acute hemorrhage in Sprague Dawley rats[1].

Animal Model:Sprague-Dawley rats[1]
Dosage:1 μg/kg?min
Administration:0-30 min
Result:Improved blood pressure and heart rate, improved levels of epinephrine and norepinephrine im plasma.

References

1. Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R. Prostaglandins and human respiratory tract smooth muscle: Structure activity relationship Adv. Prostaglandin Thromboxane Res. 7,969-980(1980).

16,16-DIMETHYL PROSTAGLANDIN E1 Preparation Products And Raw materials

Raw materials

Preparation Products

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16,16-DIMETHYL PROSTAGLANDIN E1 Suppliers

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41692-15-3, 16,16-DIMETHYL PROSTAGLANDIN E1Related Search:

16,16-DIMETHYL-6-KETO PROSTAGLANDIN E1 16,16-DIMETHYL PROSTAGLANDIN E1 11-DEOXY PROSTAGLANDIN E1 1,11ALPHA,15S-TRIHYDROXY-PROST-13E-EN-9-ONE Prostaglandin E1

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  • 16,16-dimethylprostaglandin E
  • Prost-13-en-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (11alpha,13E,15R)-
  • RQOFITYRYPQNLL-ZWSAOQBFSA-N
  • 16,16-dimethyl PGE1
  • 9-oxo-11α,15R-dihydroxy-16,16-dimethyl-prost-13E-en-1-oic acid
  • 16,16-DIMETHYL PROSTAGLANDIN E1
  • Prost-13-en-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (11α,13E,15R)-
  • 41692-15-3