1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
- Product Name
- 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
- CAS No.
- 73465-43-7
- Chemical Name
- 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
- Synonyms
- DMM;DMJ;DMJ, HYDROCHLORIDE;DEOXYMANNOJIRIMYCIN HCL;1-DEOXYMANNOJIRIMYCIN HCL;DEOXYMANNONOJIRIMYCIN HCL;1-DeoxymannojirimycineHCl;DEOXYMANNOJIRIMYCIN, HYDROCHLORIDE;1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE;1-Deoxymannojirimycinehydrochloride
- CBNumber
- CB1768822
- Molecular Formula
- C6H14ClNO4
- Formula Weight
- 199.63
- MOL File
- 73465-43-7.mol
1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Property
- Melting point:
- 183-185°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- H2O: soluble10mg/mL
- form
- Powder
- color
- white to off-white
- Water Solubility
- Soluble in water (50 mM)
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
- CAS DataBase Reference
- 73465-43-7
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-24/25-36-37/39-26
- WGK Germany
- 3
- HS Code
- 2941900000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- D9160
- Product name
- 1-Deoxymannojirimycin hydrochloride
- Packaging
- 1mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- D9160
- Product name
- 1-Deoxymannojirimycin hydrochloride
- Packaging
- 5mg
- Price
- $231
- Updated
- 2024/03/01
- Product number
- J61277
- Product name
- (+)-1-Deoxymannojirimycin hydrochloride
- Packaging
- 5mg
- Price
- $143.65
- Updated
- 2024/03/01
- Product number
- J61277
- Product name
- (+)-1-Deoxymannojirimycin hydrochloride
- Packaging
- 10mg
- Price
- $236.65
- Updated
- 2024/03/01
- Product number
- 17178
- Product name
- 1-Deoxymannojirimycin (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $28
- Updated
- 2024/03/01
1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Chemical Properties,Usage,Production
Description
1-Deoxymannojirimycin is a specific inhibitor of class I α-1,2-mannosidase (IC50 = 0.02 μM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi and for targeting misfolded proteins for translocation out of the endoplasmic reticulum and degradation by the proteasome. By inhibiting α-1,2-mannosidase activity, this compound generates N-linked oligosaccharides with high mannose content, preventing misfolded protein degradation. This compound has been used for studies on glycoprotein processing and as a model for the development of anticancer and antiviral therapies.
Chemical Properties
White Crystalline Solid
Uses
Selective inhibitor of a-mannosidase
Uses
Deoxymannojirimycin has been shown to be a potent inhibitor of the mammalian Golgi alpha- mannosidase 1 activity, blocking the conversion of high-mannose oligosaccharides to complex-type oligosaccharides. However, it does not inhibit the biosynthesis of lipid- linked oligosaccharides.
storage
+4°C
References
1) Bischoff et al. (1986), The use of 1-deoxymannojirimycin to evaluated the role of various alpha-mannosidases in oligosaccharide processing in intact cells; J. Biol. Chem., 261 4766 2) Bischoff et al. (1984), The effect of 1-deoxymannojirimycin on rat liver alpha mannosidases.; Biochem. Biophys. Res. Commun., 125 324 3) Fuhrmann et al. (1984), Novel mannosidase inhibitor blocking conversation of high mannose to complex oligosaccharides; Nature, 307 755 4) Miyake and Nagai (2009), Inhibition of alpha-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death; Neurotoxicology, 30 144 5) Tai et al. (2011), Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian? cells; J. Biol. Eng., 5? 1 6) Lee et al. (2012), Construction of stable producer cells to make high-titer lentiviral vectors for dendritic cell-based vaccination; Biotechnol. Bioeng., 109 1551
1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE manufacturers
- Product
- 1-DeoxyMannojiriMycin hydrochloride 73465-43-7
- Price
- US $0.00/G
- Min. Order
- 10G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-15