ChemicalBook > CAS DataBase List > 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE

Product Name
1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
CAS No.
73465-43-7
Chemical Name
1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
Synonyms
DMM;DMJ;DMJ, HYDROCHLORIDE;DEOXYMANNOJIRIMYCIN HCL;1-DEOXYMANNOJIRIMYCIN HCL;DEOXYMANNONOJIRIMYCIN HCL;1-DeoxymannojirimycineHCl;DEOXYMANNOJIRIMYCIN, HYDROCHLORIDE;1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE;1-Deoxymannojirimycinehydrochloride
CBNumber
CB1768822
Molecular Formula
C6H14ClNO4
Formula Weight
199.63
MOL File
73465-43-7.mol
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1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Property

Melting point:
183-185°C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
H2O: soluble10mg/mL
form 
Powder
color 
white to off-white
Water Solubility 
Soluble in water (50 mM)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
CAS DataBase Reference
73465-43-7
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-24/25-36-37/39-26
WGK Germany 
3
HS Code 
2941900000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D9160
Product name
1-Deoxymannojirimycin hydrochloride
Packaging
1mg
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
D9160
Product name
1-Deoxymannojirimycin hydrochloride
Packaging
5mg
Price
$231
Updated
2024/03/01
Alfa Aesar
Product number
J61277
Product name
(+)-1-Deoxymannojirimycin hydrochloride
Packaging
5mg
Price
$143.65
Updated
2024/03/01
Alfa Aesar
Product number
J61277
Product name
(+)-1-Deoxymannojirimycin hydrochloride
Packaging
10mg
Price
$236.65
Updated
2024/03/01
Cayman Chemical
Product number
17178
Product name
1-Deoxymannojirimycin (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$28
Updated
2024/03/01
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1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Chemical Properties,Usage,Production

Description

1-Deoxymannojirimycin is a specific inhibitor of class I α-1,2-mannosidase (IC50 = 0.02 μM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi and for targeting misfolded proteins for translocation out of the endoplasmic reticulum and degradation by the proteasome. By inhibiting α-1,2-mannosidase activity, this compound generates N-linked oligosaccharides with high mannose content, preventing misfolded protein degradation. This compound has been used for studies on glycoprotein processing and as a model for the development of anticancer and antiviral therapies.

Chemical Properties

White Crystalline Solid

Uses

Selective inhibitor of a-mannosidase

Uses

Deoxymannojirimycin has been shown to be a potent inhibitor of the mammalian Golgi alpha- mannosidase 1 activity, blocking the conversion of high-mannose oligosaccharides to complex-type oligosaccharides. However, it does not inhibit the biosynthesis of lipid- linked oligosaccharides.

storage

+4°C

References

1) Bischoff et al. (1986), The use of 1-deoxymannojirimycin to evaluated the role of various alpha-mannosidases in oligosaccharide processing in intact cells; J. Biol. Chem., 261 4766 2) Bischoff et al. (1984), The effect of 1-deoxymannojirimycin on rat liver alpha mannosidases.; Biochem. Biophys. Res. Commun., 125 324 3) Fuhrmann et al. (1984), Novel mannosidase inhibitor blocking conversation of high mannose to complex oligosaccharides; Nature, 307 755 4) Miyake and Nagai (2009), Inhibition of alpha-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death; Neurotoxicology, 30 144 5) Tai et al. (2011), Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian? cells; J. Biol. Eng., 5? 1 6) Lee et al. (2012), Construction of stable producer cells to make high-titer lentiviral vectors for dendritic cell-based vaccination; Biotechnol. Bioeng., 109 1551

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
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Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
Fax
020-39119999
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isunpharm@qq.com
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China
ProdList
4674
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Chengdu HuaXia Chemical Reagent Co. Ltd
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400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
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EMMX Biotechnology LLC
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888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
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60
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
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View Lastest Price from 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-DeoxyMannojiriMycin hydrochloride 73465-43-7
Price
US $0.00/G
Min. Order
10G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-15

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