ChemicalBook > CAS DataBase List > 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE

Product Name
1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
CAS No.
73465-43-7
Chemical Name
1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
Synonyms
DMM;DMJ;DMJ, HYDROCHLORIDE;DEOXYMANNOJIRIMYCIN HCL;1-DEOXYMANNOJIRIMYCIN HCL;DEOXYMANNONOJIRIMYCIN HCL;1-DeoxymannojirimycineHCl;DEOXYMANNOJIRIMYCIN, HYDROCHLORIDE;1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE;1-Deoxymannojirimycinehydrochloride
CBNumber
CB1768822
Molecular Formula
C6H14ClNO4
Formula Weight
199.63
MOL File
73465-43-7.mol
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1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Property

Melting point:
183-185°C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
H2O: soluble10mg/mL
form 
Powder
color 
white to off-white
Water Solubility 
Soluble in water (50 mM)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
CAS DataBase Reference
73465-43-7
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-24/25-36-37/39-26
WGK Germany 
3
HS Code 
2941900000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D9160
Product name
1-Deoxymannojirimycin hydrochloride
Packaging
1mg
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
D9160
Product name
1-Deoxymannojirimycin hydrochloride
Packaging
5mg
Price
$231
Updated
2024/03/01
Alfa Aesar
Product number
J61277
Product name
(+)-1-Deoxymannojirimycin hydrochloride
Packaging
5mg
Price
$143.65
Updated
2024/03/01
Alfa Aesar
Product number
J61277
Product name
(+)-1-Deoxymannojirimycin hydrochloride
Packaging
10mg
Price
$236.65
Updated
2024/03/01
Cayman Chemical
Product number
17178
Product name
1-Deoxymannojirimycin (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$28
Updated
2024/03/01
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1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Chemical Properties,Usage,Production

Description

1-Deoxymannojirimycin is a specific inhibitor of class I α-1,2-mannosidase (IC50 = 0.02 μM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi and for targeting misfolded proteins for translocation out of the endoplasmic reticulum and degradation by the proteasome. By inhibiting α-1,2-mannosidase activity, this compound generates N-linked oligosaccharides with high mannose content, preventing misfolded protein degradation. This compound has been used for studies on glycoprotein processing and as a model for the development of anticancer and antiviral therapies.

Chemical Properties

White Crystalline Solid

Uses

Selective inhibitor of a-mannosidase

Uses

Deoxymannojirimycin has been shown to be a potent inhibitor of the mammalian Golgi alpha- mannosidase 1 activity, blocking the conversion of high-mannose oligosaccharides to complex-type oligosaccharides. However, it does not inhibit the biosynthesis of lipid- linked oligosaccharides.

storage

+4°C

References

1) Bischoff et al. (1986), The use of 1-deoxymannojirimycin to evaluated the role of various alpha-mannosidases in oligosaccharide processing in intact cells; J. Biol. Chem., 261 4766 2) Bischoff et al. (1984), The effect of 1-deoxymannojirimycin on rat liver alpha mannosidases.; Biochem. Biophys. Res. Commun., 125 324 3) Fuhrmann et al. (1984), Novel mannosidase inhibitor blocking conversation of high mannose to complex oligosaccharides; Nature, 307 755 4) Miyake and Nagai (2009), Inhibition of alpha-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death; Neurotoxicology, 30 144 5) Tai et al. (2011), Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian? cells; J. Biol. Eng., 5? 1 6) Lee et al. (2012), Construction of stable producer cells to make high-titer lentiviral vectors for dendritic cell-based vaccination; Biotechnol. Bioeng., 109 1551

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Suppliers

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View Lastest Price from 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-DeoxyMannojiriMycin hydrochloride 73465-43-7
Price
US $0.00/G
Min. Order
10G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-15

73465-43-7, 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDERelated Search:

SKF 96365 HYDROCHLORIDE A 967079 GF109203X SWAINSONINE Bleomycin A5 Doxycycline Mannan Oligosaccharides terramycin hy drochloride,oxytetracycline hydrochl Clindamycin hydrochloride 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE (R)-3-ISOPROPYLAMINO-1,2-PROPANEDIOL 3-Hydroxypiperidine hydrochloride N-ButyldeoxymannojirimycinHCl (R)-3-Hydroxypiperidine hydrocloride 2-CHLORO-2-DEOXY-ALPHA-D-GLUCOPYRANOSYL(1-3)-1-DEOXY-MANNOJIRIMYCIN DEOXYMANNOJIRIMYCIN

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  • (2R,3R,4R,5R)-2-(HYDROXYMETHYL)-3,4,5-PIPERIDINETRIOL HYDROCHLORIDE
  • 1-DeoxymannojirimycineHCl
  • 1-Deoxymannojirimycinehydrochloride
  • 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride, (2R,3R,4R,5R)-
  • 1-Deoxymannojirimycin hydrochloride min. 98%
  • DMJ HCl, (2R,3R,4R,5R)-2-(Hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
  • Manno-1-deoxynojiriMycin Hydrochloride
  • 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE USP/EP/BP
  • 73465-43-7
  • C6H13NO4xHCl
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