4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride

Product Name: 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
CAS No.: 30827-99-7
Chemical Name: 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
Synonyms: AEBSF;AEBSF HCL;AEBSF HYDROCHLORIDE;CS-2583;AEBSF HCI;PEFABLOC SC;PEFABLOC(R) SC;AEBSF Solution;PEFABLOC SC PLUS;TIMTEC-BB SBB003219
CBNumber: CB1769137
Molecular Formula: C8H11ClFNO2S
Formula Weight: 239.69
MOL File: 30827-99-7.mol

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4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Property

Melting point:: 175-177 °C
storage temp.: 2-8°C
solubility: H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.)
form: Powder
color: White
PH: pH3.0～5.0 (10g/L, 25℃)
Water Solubility: 10 g/L (20 ºC)
Sensitive: Moisture Sensitive
BRN: 7604627
Stability:: Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator
InChIKey: WRDABNWSWOHGMS-UHFFFAOYSA-N
CAS DataBase Reference: 30827-99-7(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-36/37/38
Safety Statements: 45-36/37/39-26-36
RIDADR: UN 3261
WGK Germany: 3
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: II
HS Code: 29214990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 76307
Product name: Pefabloc? SC
Purity: analytical standard
Packaging: 100mg
Price: $137
Updated: 2024/03/01

Sigma-Aldrich

Product number: 76307
Product name: Pefabloc? SC
Purity: analytical standard
Packaging: 1g
Price: $902
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.32586
Product name: AEBSF,HCl≥99%byHPLC-CAS30827-99-7-Calbiochem
Packaging: 250mg
Price: $260
Updated: 2024/03/01

Sigma-Aldrich

Product number: 101500
Product name: AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem
Purity: AEBSF,CAS30827-99-7,isaspecificirreversibleinhibitorofchymotrypsin,kal
Packaging: 100mg
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: 101500
Product name: AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem
Purity: AEBSF,CAS30827-99-7,isaspecificirreversibleinhibitorofchymotrypsin,kal
Packaging: 500mg
Price: $504
Updated: 2024/03/01

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4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Chemical Properties,Usage,Production

Description

AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.

Chemical Properties

white powder

Uses

AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

Uses

Recommended concentrations for use are 0.1-1 mM.

General Description

Pefabloc^? SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride.

Biochem/physiol Actions

Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25?mM.

storage

Store at -20°C

References

1) Powers?et al. (2002),?Irreversible inhibitors of serine, cysteine and threonine proteases; Chem. Rev.,?102?4639 2) Diatchuk?et al.?(1997),?Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds; J. Biol. Chem.,?272?13292

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Suppliers

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View Lastest Price from 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride 30827-99-7
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-19

Anhui Zhongda Biotechnology Co., Ltd

Product: 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride 30827-99-7
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100000tons
Release date: 2023-08-09

Anhui Zhongda Biotechnology Co., Ltd

Product: AEBSF HCl 30827-99-7
Price: US $90.00-70.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000/month
Release date: 2023-08-14

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Pefabloc SC 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride AEBSF

InSolution? AEBSF, Hydrochloride

AEBSF Ready Made Solution

4-(2-AMINOETHYL)BENZENESULFONYLFLUORIDE HYDROCHLOR

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TIMTEC-BB SBB003219

PEFABLOC(R) SC

PEFABLOC SC

PEFABLOC SC PLUS

AEBSF HYDROCHLORIDE (4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE HYDROCHLORIDE)

4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 98+%

4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, AEBSF

4-(2-Aminoethyl)benzenesulfonyl Fluoride Hydrochloride [for Biochemical Research]

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4-(2-Aminoetyl)-benzen

4-(2-Aminoethyl)benz

AEBSF hydrochloride (4-(2-Aminoethyl)benzenesulfonyl fluoride hy

4-(2-AMinoethyl)benzene-1-sulfonyl fluoride hydrochloride

CS-2583

InSolution AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem

4-(2-Aminoethyl)benzenesulfonyl Fluoride Hydrochloride [for Biochemical Research]&gt

Aminoethyl Research

AEBSF Hydrochloride extrapure AR, 98%

AEBSF Solution

30827-99-7

C8H10FNO2SClH

C8H11ClFNO2S

C6H10FNO2SHCl

C8H10FNO2SHCl

C8H11FNO2SCl

C8H10FNO2SxHCl

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