4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
- Product Name
- 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
- CAS No.
- 30827-99-7
- Chemical Name
- 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
- Synonyms
- AEBSF;AEBSF HCL;AEBSF HYDROCHLORIDE;CS-2583;AEBSF HCI;PEFABLOC SC;PEFABLOC(R) SC;AEBSF Solution;PEFABLOC SC PLUS;TIMTEC-BB SBB003219
- CBNumber
- CB1769137
- Molecular Formula
- C8H11ClFNO2S
- Formula Weight
- 239.69
- MOL File
- 30827-99-7.mol
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Property
- Melting point:
- 175-177 °C
- storage temp.
- 2-8°C
- solubility
- H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.)
- form
- Powder
- color
- White
- PH
- pH3.0～5.0 (10g/L, 25℃)
- Water Solubility
- 10 g/L (20 ºC)
- Sensitive
- Moisture Sensitive
- BRN
- 7604627
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator
- InChIKey
- WRDABNWSWOHGMS-UHFFFAOYSA-N
- CAS DataBase Reference
- 30827-99-7(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-36/37/38
- Safety Statements
- 45-36/37/39-26-36
- RIDADR
- UN 3261
- WGK Germany
- 3
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29214990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 76307
- Product name
- Pefabloc? SC
- Purity
- analytical standard
- Packaging
- 100mg
- Price
- $137
- Updated
- 2024/03/01
- Product number
- 76307
- Product name
- Pefabloc? SC
- Purity
- analytical standard
- Packaging
- 1g
- Price
- $902
- Updated
- 2024/03/01
- Product number
- 5.32586
- Product name
- AEBSF,HCl≥99%byHPLC-CAS30827-99-7-Calbiochem
- Packaging
- 250mg
- Price
- $260
- Updated
- 2024/03/01
- Product number
- 101500
- Product name
- AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem
- Purity
- AEBSF,CAS30827-99-7,isaspecificirreversibleinhibitorofchymotrypsin,kal
- Packaging
- 100mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 101500
- Product name
- AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem
- Purity
- AEBSF,CAS30827-99-7,isaspecificirreversibleinhibitorofchymotrypsin,kal
- Packaging
- 500mg
- Price
- $504
- Updated
- 2024/03/01
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Chemical Properties,Usage,Production
Description
AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.
Chemical Properties
white powder
Uses
AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.
Uses
Recommended concentrations for use are 0.1-1 mM.
General Description
Pefabloc? SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride.
Biochem/physiol Actions
Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25?mM.
storage
Store at -20°C
References
1) Powers?et al. (2002),?Irreversible inhibitors of serine, cysteine and threonine proteases; Chem. Rev.,?102?4639 2) Diatchuk?et al.?(1997),?Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds; J. Biol. Chem.,?272?13292
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride manufacturers
- Product
- 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride 30827-99-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-19
- Product
- 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride 30827-99-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-05
- Product
- 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride 30827-99-7
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100000tons
- Release date
- 2023-08-09