ETHYL 2-AMINO-4-FLUOROBENZOATE

ETHYL 2-AMINO-4-FLUOROBENZOATE Property

Boiling point:

271.2±20.0 °C(Predicted)

Density 

1.218±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

1.46±0.10(Predicted)

Appearance

Light yellow to brown Solid

Safety

HS Code 

2916399090

Hazard and Precautionary Statements (GHS)

ETHYL 2-AMINO-4-FLUOROBENZOATE Chemical Properties,Usage,Production

Synthesis

A. Synthesis of ethyl 2-amino-4-fluorobenzoate 2-Amino-4-fluorobenzoic acid (1.57 g, 10.1 mmol) was dissolved in anhydrous ethanol (20 mL) and cooled to low temperature. Pure thionyl chloride (4.4 mL, 60 mmol) was added slowly and the reaction mixture was refluxed for 4 days. Subsequently, thionyl chloride (8 mL, 110 mmol) was added supplementally and the mixture was concentrated after the reaction was completed. It was diluted with ethyl acetate (EtOAc), washed with 2N sodium hydroxide (NaOH) solution, dried and concentrated in vacuum to give ethyl 2-amino-4-fluorobenzoate (1.73 g, 94% yield).

References

[1] Patent: US2002/77486, 2002, A1
[2] Patent: US6906063, 2005, B2
[3] Patent: EP1380576, 2004, A1. Location in patent: Page 97