Cbz-L-Threonine benzyl ester

Product Name: Cbz-L-Threonine benzyl ester
CAS No.: 16597-50-5
Chemical Name: Cbz-L-Threonine benzyl ester
Synonyms: Z-THR-OBZL;CBZ-THR-OBZL;Z-L-Thr-OBzl;Cbz-L-Thr-OBzl;Cbz-Thr-Obzl-OH;Z-THREONINE-OBZL;CBZ-L-THR BENZYL ESTER;Z-L-THREONINE BENZYL ESTER;Cbz-L-Threonineα-benzylester;Z-L-threonine α-benzyl ester
CBNumber: CB1769692
Molecular Formula: C19H21NO5
Formula Weight: 343.37
MOL File: 16597-50-5.mol

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Cbz-L-Threonine benzyl ester Property

Melting point:: 78-82°C
Boiling point:: 536.8±50.0 °C(Predicted)
Density: 1.228±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 10.76±0.46(Predicted)
form: powder to crystal
color: White to Almost white
optical activity: Consistent with structure
CAS DataBase Reference: 16597-50-5(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2285
Product name: N-Carbobenzoxy-L-threonine Benzyl Ester
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $100
Updated: 2025/07/31

TRC

Product number: C178280
Product name: N-Carbobenzoxy-L-threonine Benzyl Ester
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 291108
Product name: Z-L-threonine alpha-benzyl ester
Packaging: 5g
Price: $360
Updated: 2021/12/16

AK Scientific

Product number: 8437AA
Product name: Z-Thr-OBzl
Packaging: 100g
Price: $407
Updated: 2021/12/16

ChemScene

Product number: CS-W008556
Product name: Z-Thr-OBzl
Purity: 99.20%
Packaging: 25g
Price: $80
Updated: 2021/12/16

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Cbz-L-Threonine benzyl ester Chemical Properties,Usage,Production

Chemical Properties

White powder

Synthesis

19728-63-3

100-39-0

84500-41-4

General procedure for the synthesis of compounds (CAS: 84500-41-4) from (2S,3R)-2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoic acid and benzyl bromide: (2S,3R)-2- benzyloxycarbonylamino-3-hydroxybutanoic acid (1.0 g, 4.0 mmol) was dissolved in a mixture of N,N-dimethylformamide (DMF, 15.0 mL) and deionized water (5.0 mL) in a mixed solvent, cesium carbonate (644.5 mg, 2.0 mmol) was added, and the reaction was stirred for 30 min at room temperature. After the reaction was completed, the reaction solution was concentrated and the residual water was removed by azeotropy with toluene (3 × 10 mL). Subsequently, a solution of benzyl bromide (0.71 mL, 5.9 mmol) in DMF (10.0 mL) was added to the dried residue and the reaction was continued for 24 hours. At the end of the reaction, the reaction was quenched by the addition of water (15 mL) and extracted with ethyl acetate (2 x 30 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by fast column chromatography with ethyl acetate/hexane (1:3, v/v) as eluent to give the target compound (1.149 g, 84% yield) as a white powder. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3), 13C NMR (125 MHz, CDCl3) and LC-ESI-MS: 1H NMR (400 MHz, CDCl3) δ 7.26-6.35 (m, 10H), 5.60 (d, 1H, J = 8.7 Hz), 5.17-5.24 (m, 2H) 5.13 (s, 2H), 4.37-4.39 (m, 2H), 1.97 (br, 1H), 1.63 (br, 1H), 1.23 (d, 1H, J = 6.3 Hz); 13C NMR (125 MHz, CDCl3) δ 171.2, 156.9, 136.2, 135.3, 128.6, 128.5, 128.5 128.5, 128.2, 128.0, 68.0, 67.4, 67.2, 59.5, 19.9; LC-ESI-MS [M + H]+ C19H21NO5 Calculated value 344.14, measured value 344.03.

References

[1] Tetrahedron Letters, 1968, p. 6323 - 6326
[2] Tetrahedron, 2018, vol. 74, # 23, p. 2891 - 2903

Cbz-L-Threonine benzyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cbz-L-Threonine benzyl ester manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Cbz-Thr-Obzl 16597-50-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-12-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cbz-L-Threonine benzyl ester 16597-50-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cbz-L-Threonine benzyl ester 16597-50-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

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16597-50-5

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