Z-PRO-NH2

Product Name: Z-PRO-NH2
CAS No.: 34079-31-7
Chemical Name: Z-PRO-NH2
Synonyms: Z-L-P;Z-PRO-NH2;CBZ-PRO-NH2;Z-L-Pro-NH2;Z-PROLINE-NH2;Z-PYRD(2)-NH2;CBZ-L-PRO NH2;Z-L-PROLINAMIDE;Z-Pro-Nh2 92.5%;Z-L-PROLINE AMIDE
CBNumber: CB7212019
Molecular Formula: C13H16N2O3
Formula Weight: 248.28
MOL File: 34079-31-7.mol

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Z-PRO-NH2 Property

Melting point:: 90-95℃
Boiling point:: 465.6±44.0 °C(Predicted)
Density: 1.263±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in Methanol
pka: 15.95±0.20(Predicted)
form: Solid
color: White to Almost white
InChI: InChI=1S/C13H16N2O3/c14-12(16)11-7-4-8-15(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H2,14,16)/t11-/m0/s1
InChIKey: ZCGHEBMEQXMRQL-NSHDSACASA-N
SMILES: N1(C(OCC2=CC=CC=C2)=O)CCC[C@H]1C(N)=O
CAS DataBase Reference: 34079-31-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 36
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 663220
Product name: Z-L-Prolinamide
Purity: 97%
Packaging: 1g
Price: $95.8
Updated: 2023/06/20

Sigma-Aldrich

Product number: 663220
Product name: Z-L-Prolinamide
Purity: 97%
Packaging: 5g
Price: $417
Updated: 2023/06/20

TCI Chemical

Product number: C3005
Product name: N-Carbobenzoxy-L-prolinamide
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: C3005
Product name: N-Carbobenzoxy-L-prolinamide
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $167
Updated: 2025/07/31

TRC

Product number: C227938
Product name: Cbz-L-Prolinamide
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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Z-PRO-NH2 Chemical Properties,Usage,Production

Chemical Properties

White crystals

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

1148-11-4

34079-31-7

General procedure for the synthesis of (S)-1-N-benzyloxycarbonylproline from N-benzyloxycarbonyl-L-proline: 1-{[(phenylmethyl)oxy]carbonyl}-L-proline (8.0 g, 32.09 mmol) was solubilized in 1,4-dioxane (40 mL), and pyridine (1.5 mL) and di-tert-butyl dicarbonate ((Boc)2O, 9.1 g 41.72 mmol). Ammonium bicarbonate (3.2 g, 40.43 mmol) was then added. The reaction mixture was stirred at room temperature overnight and then diluted with ethyl acetate (100 mL) and washed sequentially with water (50 mL) and 5% sulfuric acid (H2SO4). The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4) and filtered. The solvent was removed by distillation under reduced pressure to give a clarified oil. The oily material was ground with ether, the precipitate was collected by filtration and dried under vacuum to afford (S)-1-N-Benzyloxycarbonylprolinamide as a white solid (3.9 g, 49% yield). The mass spectrum showed [M+H]+ of 249.

References

[1] Organic and Biomolecular Chemistry, 2005, vol. 3, # 1, p. 84 - 96
[2] Synlett, 2004, # 3, p. 558 - 560
[3] Patent: WO2005/121135, 2005, A1. Location in patent: Page/Page column 240-241
[4] Canadian Journal of Chemistry, 2007, vol. 85, # 2, p. 85 - 95
[5] Journal of the American Chemical Society, 2018, vol. 140, # 5, p. 1627 - 1631

Z-PRO-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-PRO-NH2 Suppliers

Americas 1 China 170 Europe 1 Germany 6 India 3 Japan 4 South Korea 1 Switzerland 3 United Kingdom 5 United States 30 Global 224

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Energy Chemical

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Email: sales8178@energy-chemical.com
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Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
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GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
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Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
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View Lastest Price from Z-PRO-NH2 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Z-PRO-NH2 34079-31-7
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-08-02

Shanghai Xinchem Co., Ltd.

Product: Z-PRO-NH2 34079-31-7
Price: US $0.00-0.00/drums
Min. Order: 1drums
Purity: 99%min.
Supply Ability: 10tons
Release date: 2023-10-22

Career Henan Chemical Co

Product: Z-PRO-NH2 34079-31-7
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: Customized
Release date: 2018-07-31

34079-31-7, Z-PRO-NH2Related Search:

Z-PRO-GLY-NH2 Z-PHE-NH2 N-Benzyloxycarbonyl-L-proline Z-PRO-ONP Z-PRO-OSU Z-PHG-OH Cbz-L-Threonine benzyl ester Benzyl (2R,3S)-(1-carbamoyl-2-hydroxypropyl)carbamate Z-TRP-OSU Z-TYR-OH Z-PYR-OH Z-SAR-OH Z-PRO-BETANA Z-PRO-GLY-OH Z-PRO-PHE-OH Z-PRO-PRO-OH Z-PRO-NH2 Ac-L-Pro-NH2

N-ALPHA-CARBOBENZOXY-L-PYRROLIDINE-2-CARBOXYLIC ACID ALPHA-AMIDE

N-ALPHA-CARBOBENZOXY-L-PROLINE AMIDE

N-CARBOBENZOXY-L-PROLINE AMIDE

(S)-2-CARBAMOYL-1-CBZ-PYRROLIDINE

(S)-2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER

(S)-1-N-CBZ-PROLINAMIDE

Z-L-PROLINAMIDE

Z-L-PROLINE AMIDE

Z-PYRD(2)-NH2

Z-PROLINE-NH2

Z-PRO-NH2

2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER

CARBOBENZYLOXY-L-PROLINAMIDE

CBZ-PRO-NH2

CBZ-L-PROLINAMIDE

CBZ-L-PRO NH2

BENZYLOXYCARBONYL-L-PROLINAMIDE

N-BENZYLOXYCARBONYL-L-PROLINAMIDE

N-alpha-Benzyloxycarbonyl-L-proline amide

Z-L-Pro-NH2

benzyl (2S)-2-carbamoylpyrrolidine-1-carboxylate

Z-Pro-Nh2 92.5%

N-Carbobenzyloxy-L-Prolinamide

1-(Benzyloxycarbonyl)-L-prolinamide

1-Benzyloxycarbonyl-L-prolinamide

Z-L-P

(2S)-1-Phenylmethoxycarbonylpyrrolidine-2-carboxylicacid

(S)-benzyl 2-carbamoylpyrrolidine-1-carboxylate

(S)-1-Carbobenzoxypyrrolidine-2-carboxamide

Benzyloxycarbonyl-L-proline aMide

1-Pyrrolidinecarboxylicacid, 2-(aMinocarbonyl)-, phenylMethyl ester, (2S)-

N-Carbobenzoxy-L-prolinamide

(S)-Z-pyrrolidine-2-carboxylic acid amide

Z-L-proline amide98 - 102% (Assay)

N-Carbobenzoxy-L-prolinamide &gt

N-Cbz-L-prolinamide

Cbz-l-proline amide / N-benzyloxycarbonyl L-proline amide

Benzyl (S)-2-carbamoylpyrrolidine-1-carboxylate

Z-<sc>L</sc>-Prolinamide

(S)-1-Cbz-2-carbamoylpyrrolidine

34079-31-7

Proline [Pro, P]

Z-Amino Acids and Derivatives

Z-Amino acid series