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Z-PRO-NH2

Product Name
Z-PRO-NH2
CAS No.
34079-31-7
Chemical Name
Z-PRO-NH2
Synonyms
Z-L-P;Z-PRO-NH2;CBZ-PRO-NH2;Z-L-Pro-NH2;Z-PROLINE-NH2;Z-PYRD(2)-NH2;CBZ-L-PRO NH2;Z-L-PROLINAMIDE;Z-Pro-Nh2 92.5%;Z-L-PROLINE AMIDE
CBNumber
CB7212019
Molecular Formula
C13H16N2O3
Formula Weight
248.28
MOL File
34079-31-7.mol
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Z-PRO-NH2 Property

Melting point:
90-95℃
Boiling point:
465.6±44.0 °C(Predicted)
Density 
1.263±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
soluble in Methanol
pka
15.95±0.20(Predicted)
form 
Solid
color 
White to Almost white
InChI
InChI=1S/C13H16N2O3/c14-12(16)11-7-4-8-15(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H2,14,16)/t11-/m0/s1
InChIKey
ZCGHEBMEQXMRQL-NSHDSACASA-N
SMILES
N1(C(OCC2=CC=CC=C2)=O)CCC[C@H]1C(N)=O
CAS DataBase Reference
34079-31-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
36
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
663220
Product name
Z-L-Prolinamide
Purity
97%
Packaging
1g
Price
$95.8
Updated
2023/06/20
Sigma-Aldrich
Product number
663220
Product name
Z-L-Prolinamide
Purity
97%
Packaging
5g
Price
$417
Updated
2023/06/20
TCI Chemical
Product number
C3005
Product name
N-Carbobenzoxy-L-prolinamide
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$53
Updated
2025/07/31
TCI Chemical
Product number
C3005
Product name
N-Carbobenzoxy-L-prolinamide
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$167
Updated
2025/07/31
Usbiological
Product number
287783
Product name
Z-L-proline amide
Packaging
10g
Price
$353
Updated
2021/12/16
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Z-PRO-NH2 Chemical Properties,Usage,Production

Chemical Properties

White crystals

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

1148-11-4

34079-31-7

General procedure for the synthesis of (S)-1-N-benzyloxycarbonylproline from N-benzyloxycarbonyl-L-proline: 1-{[(phenylmethyl)oxy]carbonyl}-L-proline (8.0 g, 32.09 mmol) was solubilized in 1,4-dioxane (40 mL), and pyridine (1.5 mL) and di-tert-butyl dicarbonate ((Boc)2O, 9.1 g 41.72 mmol). Ammonium bicarbonate (3.2 g, 40.43 mmol) was then added. The reaction mixture was stirred at room temperature overnight and then diluted with ethyl acetate (100 mL) and washed sequentially with water (50 mL) and 5% sulfuric acid (H2SO4). The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4) and filtered. The solvent was removed by distillation under reduced pressure to give a clarified oil. The oily material was ground with ether, the precipitate was collected by filtration and dried under vacuum to afford (S)-1-N-Benzyloxycarbonylprolinamide as a white solid (3.9 g, 49% yield). The mass spectrum showed [M+H]+ of 249.

References

[1] Organic and Biomolecular Chemistry, 2005, vol. 3, # 1, p. 84 - 96
[2] Synlett, 2004, # 3, p. 558 - 560
[3] Patent: WO2005/121135, 2005, A1. Location in patent: Page/Page column 240-241
[4] Canadian Journal of Chemistry, 2007, vol. 85, # 2, p. 85 - 95
[5] Journal of the American Chemical Society, 2018, vol. 140, # 5, p. 1627 - 1631

Z-PRO-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-PRO-NH2 Suppliers

Americas 1 China 170 Europe 1 Germany 6 India 3 Japan 4 South Korea 1 Switzerland 3 United Kingdom 5 United States 30 Global 224
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from Z-PRO-NH2 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Z-PRO-NH2 34079-31-7
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-08-02
Shanghai Xinchem Co., Ltd.
Product
Z-PRO-NH2 34079-31-7
Price
US $0.00-0.00/drums
Min. Order
1drums
Purity
99%min.
Supply Ability
10tons
Release date
2023-10-22
Career Henan Chemical Co
Product
Z-PRO-NH2 34079-31-7
Price
US $100.00/KG
Min. Order
1KG
Purity
99
Supply Ability
Customized
Release date
2018-07-31

34079-31-7, Z-PRO-NH2Related Search:

Z-PRO-GLY-NH2 Z-PHE-NH2 N-Benzyloxycarbonyl-L-proline Z-PRO-ONP Z-PRO-OSU Z-PHG-OH Cbz-L-Threonine benzyl ester Benzyl (2R,3S)-(1-carbamoyl-2-hydroxypropyl)carbamate Z-TRP-OSU Z-TYR-OH Z-PYR-OH Z-SAR-OH Z-PRO-BETANA Z-PRO-GLY-OH Z-PRO-PHE-OH Z-PRO-PRO-OH Z-PRO-NH2 Ac-L-Pro-NH2

  • N-ALPHA-CARBOBENZOXY-L-PYRROLIDINE-2-CARBOXYLIC ACID ALPHA-AMIDE
  • N-ALPHA-CARBOBENZOXY-L-PROLINE AMIDE
  • N-CARBOBENZOXY-L-PROLINE AMIDE
  • (S)-2-CARBAMOYL-1-CBZ-PYRROLIDINE
  • (S)-2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER
  • (S)-1-N-CBZ-PROLINAMIDE
  • Z-L-PROLINAMIDE
  • Z-L-PROLINE AMIDE
  • Z-PYRD(2)-NH2
  • Z-PROLINE-NH2
  • Z-PRO-NH2
  • 2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER
  • CARBOBENZYLOXY-L-PROLINAMIDE
  • CBZ-PRO-NH2
  • CBZ-L-PROLINAMIDE
  • CBZ-L-PRO NH2
  • BENZYLOXYCARBONYL-L-PROLINAMIDE
  • N-BENZYLOXYCARBONYL-L-PROLINAMIDE
  • N-alpha-Benzyloxycarbonyl-L-proline amide
  • Z-L-Pro-NH2
  • benzyl (2S)-2-carbamoylpyrrolidine-1-carboxylate
  • Z-Pro-Nh2 92.5%
  • N-Carbobenzyloxy-L-Prolinamide
  • 1-(Benzyloxycarbonyl)-L-prolinamide
  • 1-Benzyloxycarbonyl-L-prolinamide
  • Z-L-P
  • (2S)-1-Phenylmethoxycarbonylpyrrolidine-2-carboxylicacid
  • (S)-benzyl 2-carbamoylpyrrolidine-1-carboxylate
  • (S)-1-Carbobenzoxypyrrolidine-2-carboxamide
  • Benzyloxycarbonyl-L-proline aMide
  • 1-Pyrrolidinecarboxylicacid, 2-(aMinocarbonyl)-, phenylMethyl ester, (2S)-
  • N-Carbobenzoxy-L-prolinamide
  • (S)-Z-pyrrolidine-2-carboxylic acid amide
  • Z-L-proline amide98 - 102% (Assay)
  • N-Carbobenzoxy-L-prolinamide &gt
  • N-Cbz-L-prolinamide
  • Cbz-l-proline amide / N-benzyloxycarbonyl L-proline amide
  • Benzyl (S)-2-carbamoylpyrrolidine-1-carboxylate
  • Z-<sc>L</sc>-Prolinamide
  • (S)-1-Cbz-2-carbamoylpyrrolidine
  • 34079-31-7
  • Proline [Pro, P]
  • Z-Amino Acids and Derivatives
  • Z-Amino acid series