N-Benzyloxycarbonyl-L-proline

Product Name: N-Benzyloxycarbonyl-L-proline
CAS No.: 1148-11-4
Chemical Name: N-Benzyloxycarbonyl-L-proline
Synonyms: Z-Pro;Z-PRO-OH;CBZ-PRO-OH;Z-L-PRO-OH;N-CBZ-L-PROLINE;CBZ-L-Pro-OH;CARBOBENZYLOXY-L-PROLINE;N-CARBOBENZYLOXY-L-PROLINE;(S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid;Z-PROLINE
CBNumber: CB0370381
Molecular Formula: C13H15NO4
Formula Weight: 249.26
MOL File: 1148-11-4.mol

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N-Benzyloxycarbonyl-L-proline Property

Melting point:: 75-77 °C
alpha: -60 º (c=2,AcOH)
Boiling point:: 392.36°C (rough estimate)
Density: 1.1952 (rough estimate)
refractive index: -40 ° (C=2, EtOH)
storage temp.: Sealed in dry,Room Temperature
solubility: Solubility in methanol, almost transparency.
form: Crystalline Powder or Crystals
pka: 3.99±0.20(Predicted)
color: White to off-white
optical activity: [α]20/D 42°, c = 2 in ethanol
BRN: 88579
InChIKey: JXGVXCZADZNAMJ-NSHDSACASA-N
CAS DataBase Reference: 1148-11-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 62-36/37/38-20/21/22
Safety Statements: 22-24/25-36-26
WGK Germany: 3
RTECS: UY0745000
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C8601
Product name: Z-Pro-OH
Purity: 99%
Packaging: 10g
Price: $88.8
Updated: 2024/03/01

TCI Chemical

Product number: C0713
Product name: N-Carbobenzoxy-L-proline
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $17
Updated: 2024/03/01

TCI Chemical

Product number: C0713
Product name: N-Carbobenzoxy-L-proline
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $33
Updated: 2024/03/01

Alfa Aesar

Product number: B21672
Product name: N-Benzyloxycarbonyl-L-proline, 98+%
Packaging: 5g
Price: $28.65
Updated: 2024/03/01

Alfa Aesar

Product number: B21672
Product name: N-Benzyloxycarbonyl-L-proline, 98+%
Packaging: 50g
Price: $141.65
Updated: 2024/03/01

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N-Benzyloxycarbonyl-L-proline Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

N-(Benzyloxycarbonyl)-L-proline is a potent in vitro and in vivo inhibitor of prolidase; a specific peptidase that cleaves dipeptides with a C-terminal prolyl and hydroxylprolyl residue. It is also used in the synthesis of N-(L-Prolyl)-β-alanine which is a derivative of the naturally occurring beta amino acid β-Alanine.

Preparation

Caution! All procedures must be carried out in an efficient fume cupboard, wearing latex gloves and chemical-proof safety goggles. ι-Proline (10.0 g, 8.7 mmol) was dissolved in 2 m sodium hydroxide solution (40 mL), and the solution was cooled to ice-water temperature. Z-Cl (20.5 g, 12 mmol) was added portionwise, with vigorous stirring or occasional shaking, over a period of 30 min at 0–5 °C to the solution of l-proline. The ice bath was then removed and stirring or occasional shaking was continued for 30 min while the reaction mixture warmed to room temperature. The mixture was then acidified to Congo red by the gradual addition of concentrated hydrochloric acid, and the oil was extracted into ethyl acetate. The extract was dried over magnesium sulfate, the mixture was filtered, and the filtrate was concentrated in vacuo. The residue was extracted/triturated with warm tetrachloromethane. The washings were decanted and the residue was further purified by recrystallization from ethyl acetate/petroleum ether.

N-Benzyloxycarbonyl-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Benzyloxycarbonyl-L-proline Suppliers

Americas 1 Belgium 1 Canada 1 China 354 Europe 3 France 3 Germany 6 Hungary 1 India 46 Japan 9 Russia 2 South Korea 1 Spain 1 Switzerland 6 United Kingdom 15 United States 71 Global 521

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View Lastest Price from N-Benzyloxycarbonyl-L-proline manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Cbz-L-Pro-OH 1148-11-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-12-18

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-Benzyloxycarbonyl-L-proline 1148-11-4
Price: US $0.00/KG
Min. Order: 10g
Purity: 99%min
Supply Ability: 100kgs
Release date: 2021-08-23

Nanjing Fred Technology Co., Ltd

Product: N-Benzyloxycarbonyl-L-proline 1148-11-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-23

1148-11-4, N-Benzyloxycarbonyl-L-prolineRelated Search:

L-PROLINE-(4-3H(N)) Trimethoprim cis-4-Hydroxy-L-proline L-Proline D-Proline N-Carbobenzyloxyglycine Z-PRO-GLY-OH N-Cbz-L-Serine Z-PRO-PHE-OH N-alpha-Benzyloxycarbonyl-L-proline amide N-Cbz-L-Tryptophan N-Cbz-L-Threonine N-Cbz-L-Phenylalanine N-Cbz-L-glutamic acid Z-PRO-GLY-NH2 Z-PRO-BETANA Z-PRO-PRO-OH Z-PRO-ONP

n-benzyloxycarbonylproline

N-Benzyloxycarbonyl-L-proline~Z-Pro-OH

N-cbz-L-proline crystalline

N-CBZ-L-Proline N-Carbobenzyloxy-L-proline

N-Cbz-L-Pro-OH

carbobenzoxyproline

CBZ-L-Pro-OH

N-Benzyloxycarbonyl-L-proline, 98+%

L-Cbz-ProlineN

Z-L-PROLINE extrapure

N-Cbz-L-proline, 98+%

(S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid

1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L-

N-[(Phenylmethoxy)carbonyl]-L-proline

N-Benzyloxycarbonyl-(S)-proline

(2S)-1,2-Pyrrolidinedicarboxylic acid 1-benzyl ester

(2S)-1,2-Pyrrolidinedicarboxylic acid hydrogen 1-benzyl ester

N-Carbobenzyloxy-L-proline,99%

(2S)-Pyrrolidine-2-carboxylic acid, N-CBZ protected

L-Proline, N-CBZ protected, (2S)-1-[(Benzyloxy)carbonyl]pyrrolidine-2-carboxylic acid

N-Carbobenzyloxy-L-proline, 99% 10GR

N-Cbz-L-proline Z-Pro-OH

(2S)-1-[(benzyloxy)carbonyl]-2-pyrrolidinecarboxylic acid

(S)-N-Benzyloxycarbonyl-L-proline

1-benzylester,l-2-pyrrolidinedicarboxylicacid

benzyloxycarbonylproline

carbobenzoxy-l-proline

carbobenzoxy-s-proline

Z-Pro-OH 99%

l-1,2-pyrrolidinedicarboxylicacid1-benzylester

Z-Pro

1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)-

1-[oxo-(phenylmethoxy)methyl]-2-pyrrolidinecarboxylic acid

(S)-Z-pyrrolidine-2-carboxylic acid

Z-L-proline≥ 99% (HPLC)

1-[(BENZYLOXY)CARBONYL]-L-PROLINE

1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(PHENYLMETHYL) ESTER, (2S)-

(2S)-1-[(BENZYLOXY)CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID

CBZ-L-PROLINE

CBZ-PRO-OH

L-CBZ-PROLINE

BENZYLOXYCARBONYL-L-PROLINE

CARBOBENZYLOXY-L-PROLINE

(S)-N-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID

N-ALPHA-BENZYLOXYCARBONYL-L-PROLINE

N-BENZYLOXYCARBONYL-L-PROLINE

N-ALPHA-CARBOBENZOXY-L-PYRROLIDINE-2-CARBOXYLIC ACID

N-ALPHA-CARBOBENZOXY-L-PROLINE

N-ALPHA-CBZ-L-PROLINE

N-CBZ-L-PROLINE

N-CBZ-L-PROLINE-OH

N-CARBOBENZOXY-L-PROLINE

N-CARBOBENZYLOXY-L-PROLINE

Z-PROLINE

Z-PRO-OH

Z-PYRD(2)-OH

Z-L-PRO-OH

1-(phenylmethyl)ester,(s)-2-pyrrolidinedicarboxylicacid