N-Benzyloxycarbonyl-L-proline
- Product Name
- N-Benzyloxycarbonyl-L-proline
- CAS No.
- 1148-11-4
- Chemical Name
- N-Benzyloxycarbonyl-L-proline
- Synonyms
- Z-Pro;Z-PRO-OH;CBZ-PRO-OH;Z-L-PRO-OH;N-CBZ-L-PROLINE;CBZ-L-Pro-OH;CARBOBENZYLOXY-L-PROLINE;N-CARBOBENZYLOXY-L-PROLINE;(S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid;Z-PROLINE
- CBNumber
- CB0370381
- Molecular Formula
- C13H15NO4
- Formula Weight
- 249.26
- MOL File
- 1148-11-4.mol
N-Benzyloxycarbonyl-L-proline Property
- Melting point:
- 75-77 °C
- alpha
- -60 º (c=2,AcOH)
- Boiling point:
- 392.36°C (rough estimate)
- Density
- 1.1952 (rough estimate)
- refractive index
- -40 ° (C=2, EtOH)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Solubility in methanol, almost transparency.
- form
- Crystalline Powder or Crystals
- pka
- 3.99±0.20(Predicted)
- color
- White to off-white
- optical activity
- [α]20/D 42°, c = 2 in ethanol
- BRN
- 88579
- InChI
- InChI=1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m0/s1
- InChIKey
- JXGVXCZADZNAMJ-NSHDSACASA-N
- SMILES
- N1(C(OCC2=CC=CC=C2)=O)CCC[C@H]1C(O)=O
- CAS DataBase Reference
- 1148-11-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 62-36/37/38-20/21/22
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 3
- RTECS
- UY0745000
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C8601
- Product name
- Z-Pro-OH
- Purity
- 99%
- Packaging
- 10g
- Price
- $153
- Updated
- 2025/07/31
- Product number
- C0713
- Product name
- N-Carbobenzoxy-L-proline
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- C0713
- Product name
- N-Carbobenzoxy-L-proline
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- 264205
- Product name
- N-Benzyloxycarbonyl-L-proline
- Packaging
- 100g
- Price
- $333
- Updated
- 2021/12/16
- Product number
- B287810
- Product name
- N-(Benzyloxycarbonyl)-L-proline
- Packaging
- 100g
- Price
- $405
- Updated
- 2021/12/16
N-Benzyloxycarbonyl-L-proline Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
N-(Benzyloxycarbonyl)-L-proline is a potent in vitro and in vivo inhibitor of prolidase; a specific peptidase that cleaves dipeptides with a C-terminal prolyl and hydroxylprolyl residue. It is also used in the synthesis of N-(L-Prolyl)-β-alanine which is a derivative of the naturally occurring beta amino acid β-Alanine.
Preparation
Caution! All procedures must be carried out in an efficient fume cupboard, wearing latex gloves and chemical-proof safety goggles. ι-Proline (10.0 g, 8.7 mmol) was dissolved in 2 m sodium hydroxide solution (40 mL), and the solution was cooled to ice-water temperature. Z-Cl (20.5 g, 12 mmol) was added portionwise, with vigorous stirring or occasional shaking, over a period of 30 min at 0–5 °C to the solution of l-proline. The ice bath was then removed and stirring or occasional shaking was continued for 30 min while the reaction mixture warmed to room temperature. The mixture was then acidified to Congo red by the gradual addition of concentrated hydrochloric acid, and the oil was extracted into ethyl acetate. The extract was dried over magnesium sulfate, the mixture was filtered, and the filtrate was concentrated in vacuo. The residue was extracted/triturated with warm tetrachloromethane. The washings were decanted and the residue was further purified by recrystallization from ethyl acetate/petroleum ether.
reaction suitability
reaction type: solution phase peptide synthesis
N-Benzyloxycarbonyl-L-proline Preparation Products And Raw materials
Raw materials
Preparation Products
N-Benzyloxycarbonyl-L-proline Suppliers
- Tel
- 021-57790084; 13918007836
- Fax
- 021-51685238
- sales@hoborchem.com
- Country
- China
- ProdList
- 392
- Advantage
- 60
- Tel
- 19135651983 19135651206
- 243332738@qq.com
- Country
- China
- ProdList
- 908
- Advantage
- 58
- Tel
- 0510-88770633 13961738808
- jingyaobiotech@126.com
- Country
- China
- ProdList
- 346
- Advantage
- 55
- Tel
- 0531-82371986 15269101859
- Fax
- 0531-82375893
- 3276840968@qq.com
- Country
- China
- ProdList
- 1604
- Advantage
- 58
- Tel
- 025-025-58367986 18913956109
- Fax
- QQ:3209878052
- amy.xiang@ally-chem.com
- Country
- China
- ProdList
- 567
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- +86 351 7031519
- Fax
- +86 351 7031519
- sales@RHFChem.com
- Country
- China
- ProdList
- 2338
- Advantage
- 56
View Lastest Price from N-Benzyloxycarbonyl-L-proline manufacturers
- Product
- N-Benzyloxycarbonyl-L-proline 1148-11-4
- Price
- US $0.00/KG
- Min. Order
- 10g
- Purity
- 99%min
- Supply Ability
- 100kgs
- Release date
- 2021-08-23
- Product
- Cbz-L-Pro-OH 1148-11-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T
- Release date
- 2023-12-18
- Product
- N-Benzyloxycarbonyl-L-proline 1148-11-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-23