ChemicalBook > CAS DataBase List > N-Benzyloxycarbonyl-L-proline
N-Benzyloxycarbonyl-L-proline
- Product Name
- N-Benzyloxycarbonyl-L-proline
- CAS No.
- 1148-11-4
- Chemical Name
- N-Benzyloxycarbonyl-L-proline
- Synonyms
- Z-Pro;Z-PRO-OH;CBZ-PRO-OH;Z-L-PRO-OH;N-CBZ-L-PROLINE;CBZ-L-Pro-OH;CARBOBENZYLOXY-L-PROLINE;N-CARBOBENZYLOXY-L-PROLINE;(S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid;Z-PROLINE
- CBNumber
- CB0370381
- Molecular Formula
- C13H15NO4
- Formula Weight
- 249.26
- MOL File
- 1148-11-4.mol
More
Less
N-Benzyloxycarbonyl-L-proline Property
- Melting point:
- 75-77 °C
- alpha
- -60 º (c=2,AcOH)
- Boiling point:
- 392.36°C (rough estimate)
- Density
- 1.1952 (rough estimate)
- refractive index
- -40 ° (C=2, EtOH)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Solubility in methanol, almost transparency.
- form
- Crystalline Powder or Crystals
- pka
- 3.99±0.20(Predicted)
- color
- White to off-white
- optical activity
- [α]20/D 42°, c = 2 in ethanol
- BRN
- 88579
- InChIKey
- JXGVXCZADZNAMJ-NSHDSACASA-N
- CAS DataBase Reference
- 1148-11-4(CAS DataBase Reference)
More
Less
Safety
- Hazard Codes
- Xn
- Risk Statements
- 62-36/37/38-20/21/22
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 3
- RTECS
- UY0745000
- HazardClass
- IRRITANT
- HS Code
- 29339900
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- C8601
- Product name
- Z-Pro-OH
- Purity
- 99%
- Packaging
- 10g
- Price
- $88.8
- Updated
- 2024/03/01
TCI Chemical
- Product number
- C0713
- Product name
- N-Carbobenzoxy-L-proline
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $17
- Updated
- 2024/03/01
TCI Chemical
- Product number
- C0713
- Product name
- N-Carbobenzoxy-L-proline
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $33
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- B21672
- Product name
- N-Benzyloxycarbonyl-L-proline, 98+%
- Packaging
- 5g
- Price
- $28.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- B21672
- Product name
- N-Benzyloxycarbonyl-L-proline, 98+%
- Packaging
- 50g
- Price
- $141.65
- Updated
- 2024/03/01
More
Less
N-Benzyloxycarbonyl-L-proline Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
N-(Benzyloxycarbonyl)-L-proline is a potent in vitro and in vivo inhibitor of prolidase; a specific peptidase that cleaves dipeptides with a C-terminal prolyl and hydroxylprolyl residue. It is also used in the synthesis of N-(L-Prolyl)-β-alanine which is a derivative of the naturally occurring beta amino acid β-Alanine.
Preparation
Caution! All procedures must be carried out in an efficient fume cupboard, wearing latex gloves and chemical-proof safety goggles. ι-Proline (10.0 g, 8.7 mmol) was dissolved in 2 m sodium hydroxide solution (40 mL), and the solution was cooled to ice-water temperature. Z-Cl (20.5 g, 12 mmol) was added portionwise, with vigorous stirring or occasional shaking, over a period of 30 min at 0–5 °C to the solution of l-proline. The ice bath was then removed and stirring or occasional shaking was continued for 30 min while the reaction mixture warmed to room temperature. The mixture was then acidified to Congo red by the gradual addition of concentrated hydrochloric acid, and the oil was extracted into ethyl acetate. The extract was dried over magnesium sulfate, the mixture was filtered, and the filtrate was concentrated in vacuo. The residue was extracted/triturated with warm tetrachloromethane. The washings were decanted and the residue was further purified by recrystallization from ethyl acetate/petroleum ether.
N-Benzyloxycarbonyl-L-proline Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
N-Benzyloxycarbonyl-L-proline Suppliers
- Tel
- 0757-18928797409 13078814179
- 1670287326@qq.com
- Country
- China
- ProdList
- 829
- Advantage
- 58
- Tel
- 21-21-61026752 13918007836
- Fax
- 021-51685238
- sales@hoborchem.com
- Country
- China
- ProdList
- 405
- Advantage
- 60
- Tel
- 19135651206 19135651206
- 243332738@qq.com
- Country
- China
- ProdList
- 895
- Advantage
- 58
- Tel
- 022-022-83946278 13820372920
- Fax
- 022-83945176
- sales@creasyn.com
- Country
- China
- ProdList
- 994
- Advantage
- 68
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006608290; 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40241
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30132
- Advantage
- 84
- Tel
- +86 351 7031519
- Fax
- +86 351 7031519
- sales@RHFChem.com
- Country
- China
- ProdList
- 2341
- Advantage
- 56
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24539
- Advantage
- 81
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44751
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35906
- Advantage
- 56
- Tel
- 21-61263452 13641803416
- Fax
- 86-21-61263399
- ymbetter@glbiochem.com
- Country
- China
- ProdList
- 9981
- Advantage
- 64
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18217
- Advantage
- 66
- Tel
- 010-82967028 13552068683
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12458
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9984
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9551
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11660
- Advantage
- 64
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9816
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 17987
- Advantage
- 64
- Tel
- 021-54306202 13764082696;
- info@hanhongsci.com
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15421
- Advantage
- 60
- Tel
- 0712-0712-2580635 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8849
- Advantage
- 52
- Tel
- 13355009207 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18739
- Advantage
- 57
- Tel
- 021-50460086-9 15921403865
- Fax
- +86-21-50462321
- han_yajun@dctc.daicel.com
- Country
- China
- ProdList
- 6854
- Advantage
- 65
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12990
- Advantage
- 57
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11726
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14443
- Advantage
- 57
- Tel
- +86-028-60911900 13540204019
- sales@afbiochem.com
- Country
- China
- ProdList
- 493
- Advantage
- 57
- Tel
- +86 (573) 82222445 (0)18006601000 452520369
- Fax
- +86 (573) 82222643
- sales@maya-r.com
- Country
- China
- ProdList
- 11714
- Advantage
- 57
- Tel
- 0370-2785118 15343847665
- Fax
- QQ：3470079902
- huawenchem@163.com
- Country
- China
- ProdList
- 3206
- Advantage
- 55
- Tel
- 027-027-59207852 13308628970
- Fax
- QQ3130921841
- buy@fortunachem.com
- Country
- China
- ProdList
- 2893
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9872
- Advantage
- 52
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17779
- Advantage
- 75
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- 400-810-7969 010-59572699
- Fax
- 010-59572688
- ningzi.li@inno-chem.com.cn
- Country
- China
- ProdList
- 6139
- Advantage
- 55
- Tel
- 13901585132
- Fax
- +86-25-52131256
- 799750417@qq.com
- Country
- China
- ProdList
- 8888
- Advantage
- 55
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4171
- Advantage
- 58
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22519
- Advantage
- 55
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4576
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9906
- Advantage
- 55
- Tel
- 025-84699383-8003 18013301590
- Fax
- 025-84699383-8003
- njduly@126.com
- Country
- China
- ProdList
- 973
- Advantage
- 55
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 15366717998
- Fax
- 0523-86201489
- thbiochem@126.com
- Country
- China
- ProdList
- 87
- Advantage
- 58
- Tel
- 021-61119791,13386096464
- Fax
- 021-50190009
- bzswkf@foxmail.com
- Country
- China
- ProdList
- 3924
- Advantage
- 50
- Tel
- 015380367604 15380367604
- Fax
- 0514-83828236
- Country
- China
- ProdList
- 509
- Advantage
- 55
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9908
- Advantage
- 55
- Tel
- 0574-87365517 18074210286
- Fax
- 87367735
- sales@taikangchem.com
- Country
- China
- ProdList
- 303
- Advantage
- 58
More
Less
View Lastest Price from N-Benzyloxycarbonyl-L-proline manufacturers
Sichuan HongRi Pharma-Tech Co.,Ltd
- Product
- Cbz-L-Pro-OH 1148-11-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T
- Release date
- 2023-12-18
Henan Fengda Chemical Co., Ltd
- Product
- Z-Pro-OH 1148-11-4
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-02
Hebei Duling International Trade Co. LTD
- Product
- N-Benzyloxycarbonyl-L-proline 1148-11-4
- Price
- US $56.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 tons
- Release date
- 2023-03-02
1148-11-4, N-Benzyloxycarbonyl-L-prolineRelated Search:
L-PROLINE-(4-3H(N))
Trimethoprim
cis-4-Hydroxy-L-proline
L-Proline
D-Proline
N-Carbobenzyloxyglycine
Z-PRO-GLY-OH
N-Cbz-L-Serine
Z-PRO-PHE-OH
N-alpha-Benzyloxycarbonyl-L-proline amide
N-Cbz-L-Tryptophan
N-Cbz-L-Threonine
N-Cbz-L-Phenylalanine
N-Cbz-L-glutamic acid
Z-PRO-GLY-NH2
Z-PRO-BETANA
Z-PRO-PRO-OH
Z-PRO-ONP