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N-Benzyloxycarbonyl-L-proline

Product Name
N-Benzyloxycarbonyl-L-proline
CAS No.
1148-11-4
Chemical Name
N-Benzyloxycarbonyl-L-proline
Synonyms
Z-Pro;Z-PRO-OH;CBZ-PRO-OH;Z-L-PRO-OH;N-CBZ-L-PROLINE;CBZ-L-Pro-OH;CARBOBENZYLOXY-L-PROLINE;N-CARBOBENZYLOXY-L-PROLINE;(S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid;Z-PROLINE
CBNumber
CB0370381
Molecular Formula
C13H15NO4
Formula Weight
249.26
MOL File
1148-11-4.mol
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N-Benzyloxycarbonyl-L-proline Property

Melting point:
75-77 °C
alpha 
-60 º (c=2,AcOH)
Boiling point:
392.36°C (rough estimate)
Density 
1.1952 (rough estimate)
refractive index 
-40 ° (C=2, EtOH)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Solubility in methanol, almost transparency.
form 
Crystalline Powder or Crystals
pka
3.99±0.20(Predicted)
color 
White to off-white
optical activity
[α]20/D 42°, c = 2 in ethanol
BRN 
88579
InChIKey
JXGVXCZADZNAMJ-NSHDSACASA-N
CAS DataBase Reference
1148-11-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
62-36/37/38-20/21/22
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
UY0745000
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C8601
Product name
Z-Pro-OH
Purity
99%
Packaging
10g
Price
$88.8
Updated
2024/03/01
TCI Chemical
Product number
C0713
Product name
N-Carbobenzoxy-L-proline
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$17
Updated
2024/03/01
TCI Chemical
Product number
C0713
Product name
N-Carbobenzoxy-L-proline
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$33
Updated
2024/03/01
Alfa Aesar
Product number
B21672
Product name
N-Benzyloxycarbonyl-L-proline, 98+%
Packaging
5g
Price
$28.65
Updated
2024/03/01
Alfa Aesar
Product number
B21672
Product name
N-Benzyloxycarbonyl-L-proline, 98+%
Packaging
50g
Price
$141.65
Updated
2024/03/01
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N-Benzyloxycarbonyl-L-proline Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

N-(Benzyloxycarbonyl)-L-proline is a potent in vitro and in vivo inhibitor of prolidase; a specific peptidase that cleaves dipeptides with a C-terminal prolyl and hydroxylprolyl residue. It is also used in the synthesis of N-(L-Prolyl)-β-alanine which is a derivative of the naturally occurring beta amino acid β-Alanine.

Preparation

Caution! All procedures must be carried out in an efficient fume cupboard, wearing latex gloves and chemical-proof safety goggles. ι-Proline (10.0 g, 8.7 mmol) was dissolved in 2 m sodium hydroxide solution (40 mL), and the solution was cooled to ice-water temperature. Z-Cl (20.5 g, 12 mmol) was added portionwise, with vigorous stirring or occasional shaking, over a period of 30 min at 0–5 °C to the solution of l-proline. The ice bath was then removed and stirring or occasional shaking was continued for 30 min while the reaction mixture warmed to room temperature. The mixture was then acidified to Congo red by the gradual addition of concentrated hydrochloric acid, and the oil was extracted into ethyl acetate. The extract was dried over magnesium sulfate, the mixture was filtered, and the filtrate was concentrated in vacuo. The residue was extracted/triturated with warm tetrachloromethane. The washings were decanted and the residue was further purified by recrystallization from ethyl acetate/petroleum ether.

N-Benzyloxycarbonyl-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Benzyloxycarbonyl-L-proline Suppliers

Americas 1 Belgium 1 Canada 1 China 340 Europe 3 France 3 Germany 6 Hungary 1 India 45 Japan 9 Russia 2 South Korea 1 Spain 1 Switzerland 6 United Kingdom 15 United States 72 Global 507
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23680
Advantage
75
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View Lastest Price from N-Benzyloxycarbonyl-L-proline manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Cbz-L-Pro-OH 1148-11-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-12-18
Henan Fengda Chemical Co., Ltd
Product
Z-Pro-OH 1148-11-4
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-02
Hebei Duling International Trade Co. LTD
Product
N-Benzyloxycarbonyl-L-proline 1148-11-4
Price
US $56.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 tons
Release date
2023-03-02

1148-11-4, N-Benzyloxycarbonyl-L-prolineRelated Search:

L-PROLINE-(4-3H(N)) Trimethoprim cis-4-Hydroxy-L-proline L-Proline D-Proline N-Carbobenzyloxyglycine Z-PRO-GLY-OH N-Cbz-L-Serine Z-PRO-PHE-OH N-alpha-Benzyloxycarbonyl-L-proline amide N-Cbz-L-Tryptophan N-Cbz-L-Threonine N-Cbz-L-Phenylalanine N-Cbz-L-glutamic acid Z-PRO-GLY-NH2 Z-PRO-BETANA Z-PRO-PRO-OH Z-PRO-ONP

  • n-benzyloxycarbonylproline
  • N-Benzyloxycarbonyl-L-proline~Z-Pro-OH
  • N-cbz-L-proline crystalline
  • N-CBZ-L-Proline N-Carbobenzyloxy-L-proline
  • N-Cbz-L-Pro-OH
  • carbobenzoxyproline
  • CBZ-L-Pro-OH
  • N-Benzyloxycarbonyl-L-proline, 98+%
  • L-Cbz-ProlineN
  • Z-L-PROLINE extrapure
  • N-Cbz-L-proline, 98+%
  • (S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid
  • 1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L-
  • N-[(Phenylmethoxy)carbonyl]-L-proline
  • N-Benzyloxycarbonyl-(S)-proline
  • (2S)-1,2-Pyrrolidinedicarboxylic acid 1-benzyl ester
  • (2S)-1,2-Pyrrolidinedicarboxylic acid hydrogen 1-benzyl ester
  • N-Carbobenzyloxy-L-proline,99%
  • (2S)-Pyrrolidine-2-carboxylic acid, N-CBZ protected
  • L-Proline, N-CBZ protected, (2S)-1-[(Benzyloxy)carbonyl]pyrrolidine-2-carboxylic acid
  • N-Carbobenzyloxy-L-proline, 99% 10GR
  • N-Cbz-L-proline Z-Pro-OH
  • (2S)-1-[(benzyloxy)carbonyl]-2-pyrrolidinecarboxylic acid
  • (S)-N-Benzyloxycarbonyl-L-proline
  • 1-benzylester,l-2-pyrrolidinedicarboxylicacid
  • benzyloxycarbonylproline
  • carbobenzoxy-l-proline
  • carbobenzoxy-s-proline
  • Z-Pro-OH 99%
  • l-1,2-pyrrolidinedicarboxylicacid1-benzylester
  • Z-Pro
  • 1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)-
  • 1-[oxo-(phenylmethoxy)methyl]-2-pyrrolidinecarboxylic acid
  • (S)-Z-pyrrolidine-2-carboxylic acid
  • Z-L-proline≥ 99% (HPLC)
  • 1-[(BENZYLOXY)CARBONYL]-L-PROLINE
  • 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(PHENYLMETHYL) ESTER, (2S)-
  • (2S)-1-[(BENZYLOXY)CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID
  • CBZ-L-PROLINE
  • CBZ-PRO-OH
  • L-CBZ-PROLINE
  • BENZYLOXYCARBONYL-L-PROLINE
  • CARBOBENZYLOXY-L-PROLINE
  • (S)-N-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID
  • N-ALPHA-BENZYLOXYCARBONYL-L-PROLINE
  • N-BENZYLOXYCARBONYL-L-PROLINE
  • N-ALPHA-CARBOBENZOXY-L-PYRROLIDINE-2-CARBOXYLIC ACID
  • N-ALPHA-CARBOBENZOXY-L-PROLINE
  • N-ALPHA-CBZ-L-PROLINE
  • N-CBZ-L-PROLINE
  • N-CBZ-L-PROLINE-OH
  • N-CARBOBENZOXY-L-PROLINE
  • N-CARBOBENZYLOXY-L-PROLINE
  • Z-PROLINE
  • Z-PRO-OH
  • Z-PYRD(2)-OH
  • Z-L-PRO-OH
  • 1-(phenylmethyl)ester,(s)-2-pyrrolidinedicarboxylicacid