BW 723C86

Product Name: BW 723C86
CAS No.: 160521-72-2
Chemical Name: BW 723C86
Synonyms: BW 723C8;BW 723C86;BW723C86HCl;Zinc02379519;BW 723C86[B175];BW 723C86 hydrochlor;BW-723C86 (BW 723C86;BW 723C86 HYDROCHLORIDE;A-Methyl-5-(2-Thienylmethox;BW 723C86 \ 5-HT2B SEROTONIN RECEPTOR AG ONIST
CBNumber: CB1771558
Molecular Formula: C16H19ClN2OS
Formula Weight: 322.85
MOL File: 160521-72-2.mol

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BW 723C86 Property

storage temp.: Desiccate at +4°C
solubility: DMSO: >10 mg/mL
form: solid
color: white
Water Solubility: H2O: 1mg/mL, clear
InChI: 1S/C16H18N2OS.ClH/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14;/h2-6,8-9,11,18H,7,10,17H2,1H3;1H
InChIKey: PYJBJMIBANAOFJ-UHFFFAOYSA-N
SMILES: Cl.CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12

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Safety

WGK Germany: 3
RTECS: NL8504715
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B175
Product name: BW 723C86
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $233
Updated: 2025/07/31

Sigma-Aldrich

Product number: B175
Product name: BW 723C86
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $748
Updated: 2025/07/31

Cayman Chemical

Product number: 70090
Product name: BW 723C86
Purity: ≥98%
Packaging: 1mg
Price: $18
Updated: 2024/03/01

Cayman Chemical

Product number: 70090
Product name: BW 723C86
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 70090
Product name: BW 723C86
Purity: ≥98%
Packaging: 10mg
Price: $129
Updated: 2024/03/01

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BW 723C86 Chemical Properties,Usage,Production

Uses

BW 723C86 is a selective 5-HT2B receptor agonist. It is used in the treatment of certain CNS disorders, in particular epilepsy, migraine and feeding disorders.

Biological Activity

Selective 5-HT 2B receptor agonist.

Biochem/physiol Actions

5-HT2B serotonin receptor agonist.

in vivo

BW-723C86 (1-20 mg/kg, s.c., 30 min pre-test (grooming)) causes hyperphagia and decreased grooming in rats, with increasing the time spent in feeding behaviour^[2].
BW-723C86 (10-30 mg/kg, i.p. 30 min pre-test) shows anxiolytic effects in rats via 5-HT_2B receptor^[3].
BW-723C86 (3-10 mg/kg, s.c. 30 min pretest) exerts an appreciable anxiolytic-like profile in rats, with increasing total social interaction^[4].
BW-723C86 (5 mg/kg, p.o., 20 or 30 min before the liquid meal) inhibits liquid meal-induced gastric accommodation in normal Hartley guinea pigs^[5].

Animal Model:	Male Sprague Dawley (CD) rats (220–250 g) for vogel conflict test^[3]
Dosage:	0.3, 1, 3, 10, 30 mg/kg
Administration:	Intraperitoneal injection (i.p.), 30 min pre-test
Result:	Increased the number of punishments accepted in the rat Vogel conflict test over 3 min. Had no significant effect on either the amount of time spent drinking or the latency to drink. Did not affect apparent shock sensitivity.

IC 50

5-HT_2B Receptor

storage

Desiccate at +4°C

References

[1]. kennett ga, bright f, trail b, et al. effects of the 5-ht2b receptor agonist, bw 723c86, on three rat models of anxiety. br j pharmacol, 1996, 117(7): 1443-1448.
[2]. dergacheva o, wang x, kamendi h, et al. 5ht2 receptor activation facilitates p2x receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus. neuropharmacology, 2008, 54(7): 1095-1102.
[3]. kennett ga, trail b, bright f. anxiolytic-like actions of bw 723c86 in the rat vogel conflict test are 5-ht2b receptor mediated. neuropharmacology, 1998, 37(12): 1603-1610.
[4]. urtikova n, berson n, van steenwinckel j, et al. antinociceptive effect of peripheral serotonin 5-ht2b receptor activation on neuropathic pain. pain, 2012, 153(6): 1320-1331.

BW 723C86 Preparation Products And Raw materials

Raw materials

Preparation Products

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BW 723C86 Suppliers

Canada 1 China 45 Europe 1 Germany 3 Switzerland 1 United Kingdom 2 United States 9 USA 1 Global 63

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
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3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
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Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
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Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
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EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
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Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
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Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471;
Email: sales@sarms4muscle.com
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
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Email: sales@hzclap.com
Country: CHINA
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
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CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
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160521-72-2, BW 723C86Related Search:

Trimethylamine hydrochloride 5-Methoxytryptamine BW 723C86 5-Methoxy-alpha-methyltryptaminehydrochloride 5-Methoxy-alpha-methyltryptamine

BW 723C86

BW 723C86 HYDROCHLORIDE

ALPHA-METHYL-5-(2-THIENYLMETHOXY)-1H-INDOLE-3-ETHANAMINE HYDROCHLORIDE

ALPHA-METHYL-5-(2-THIENYLMETHOXY)-1H-INDOLE-3-ETHANAMINE, MONOHYDROCHLORIDE

BW 723C86 \ 5-HT2B SEROTONIN RECEPTOR AG ONIST

a-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanaminehydrochloride

BW723C86HCl

a-Methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine Monohydrochloride

BW 723C8

α-Methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine Monohydrochloride

Zinc02379519

α-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanaminehydrochloride

1-(5-(Thiophen-2-ylmethoxy)-1H-indol-3-yl)propan-2-amine hydrochloride

A-Methyl-5-(2-Thienylmethox

BW-723C86 (BW 723C86

Α-METHYL-5-(2-THIENYLMETHOXY)-1H-INDOLE-3-,ETHANAMINEMONOHYDROCHLORIDE(BW723C86)

BW 723C86 hydrochlor

1H-Indole-3-ethanamine, α-methyl-5-(2-thienylmethoxy)-, hydrochloride (1:1)

BW 723C86[B175]

α-Methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine Monohydrochloride

160521-72-2

C16H19ClN2OS

C16H18N2OSHCl

Intermediates & Fine Chemicals

Pharmaceuticals

Serotonin receptor