4-NITROPHENYL-2-METHOXYETHYL ETHER

4-NITROPHENYL-2-METHOXYETHYL ETHER Property

Melting point:

87 °C

Boiling point:

317.0±22.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

Safety

HS Code 

2909309090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-NITROPHENYL-2-METHOXYETHYL ETHER Chemical Properties,Usage,Production

Synthesis

To a solution of N,N-dimethylformamide (DMF, 10 mL) of 4-nitrophenol (2.78 g, 20 mmol) and 2-bromoethyl methyl ether (3.6 g, 26 mmol) was added anhydrous potassium carbonate (K2CO3, 5.52 g, 40 mmol). The reaction mixture was stirred at 80 °C for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was subsequently quenched with deionized water (30 mL) and ethyl acetate (EtOAc, 40 mL). The organic and aqueous layers were separated and the aqueous layer was further extracted with ethyl acetate (2 x 25 mL). All organic extracts were combined, washed with saturated sodium chloride solution (brine, 2×20 mL), dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford the target product, 4-nitrophenyl-2-methoxyethyl ether (3.9 g, 100% yield) as a yellow solid.

References

[1] Patent: WO2014/130693, 2014, A1. Location in patent: Paragraph 00544; 00546
[2] Patent: WO2015/6754, 2015, A2. Location in patent: Paragraph 00243; 00244
[3] European Journal of Medicinal Chemistry, 1980, vol. 15, # 5, p. 399 - 404
[4] Patent: US2005/277668, 2005, A1. Location in patent: Page/Page column 17