1-(4-Aminophenyl)cyclopentanecarbonitrile
- Product Name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- CAS No.
- 115279-73-7
- Chemical Name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Synonyms
- KML-54;ASISCHEM D50964;1-(4-AMINOPHENYL)CYCLOPENTANECARBONITRILE;Cyclopentanecarbonitrile, 1-(4-aminophenyl)-;1-(4-aminophenyl)-1-cyclopentanecarbonitrile;1-(4-aminophenyl)cyclopentane-1-carbonitrile;1-(4-aminophenyl)cyclopentanecarbonitrile(SALTDATA: FREE)
- CBNumber
- CB1799242
- Molecular Formula
- C12H14N2
- Formula Weight
- 186.25
- MOL File
- 115279-73-7.mol
1-(4-Aminophenyl)cyclopentanecarbonitrile Property
- Boiling point:
- 375.0±35.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 5.05±0.10(Predicted)
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H341Suspected of causing genetic defects
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A615550
- Product name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- OR952958
- Product name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Packaging
- 250mg
- Price
- $156
- Updated
- 2021/12/16
- Product number
- FA153769
- Product name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FA153769
- Product name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 3H37-1-8W
- Product name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Purity
- 95%
- Packaging
- 250mg
- Price
- $184
- Updated
- 2021/12/16
1-(4-Aminophenyl)cyclopentanecarbonitrile Chemical Properties,Usage,Production
Uses
1-(4-Aminophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
Synthesis
1-(4-Aminophenyl)cyclopentanecarbonitrile is synthesised using 1-(4-nitrophenyl)cyclopentanecarbonitrile as a raw material by chemical reaction. The specific synthesis steps are as follows:
General procedure: The kilogram-scale reaction was performed in a 50 L single-deckglass reactor with the following conditions: 3 m (3 kg, 6.3 mol), FeO(OH)/C (460 g, 0.63 mol, 0.1 equiv), ethanol (20 L) and 80% N2H4H2O(800 g, 12.6 mol, 2 equiv) were added to a 50 L single-deck glass reactorat N2 atmosphere, then rising up the temperature to 75 C. The reactantwas stirred at 75 C for about 5 h. After the reaction was finished, the FeO(OH)/C catalyst was filtered off and washed with dichloromethane(5 L). The solvents were removed in vacuo and dried overnight byvacuum drying oven to get off-white powder 4m (2.67 kg, 6 mol), withHPLC purity >99.5%, yield 92.5%.
1-(4-Aminophenyl)cyclopentanecarbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
1-(4-Aminophenyl)cyclopentanecarbonitrile Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94838
- Advantage
- 76
- Tel
- +86-21-68182121
- Fax
- +86-21-68182121
- Country
- China
- ProdList
- 882
- Advantage
- 52
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7891
- Advantage
- 64
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11660
- Advantage
- 64
- Tel
- 0510-0510-83593305
- Fax
- 0086-510-83593305
- sales@huifeichem.com
- Country
- China
- ProdList
- 104
- Advantage
- 62
- Tel
- 025-66099280 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19918
- Advantage
- 55
- Tel
- sales@witofly.com
- Country
- China
- ProdList
- 2867
- Advantage
- 52
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9352
- Advantage
- 58
- Tel
- 18019252918
- Fax
- QQ:1454668768
- sale@amkchem.com
- Country
- China
- ProdList
- 15415
- Advantage
- 55
View Lastest Price from 1-(4-Aminophenyl)cyclopentanecarbonitrile manufacturers
- Product
- 1-(4-Aminophenyl)cyclopentanecarbonitrile 115279-73-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 98% Min.
- Supply Ability
- 500kg
- Release date
- 2024-01-25
- Product
- ASISCHEM D50964 115279-73-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-19
- Product
- ASISCHEM D50964 115279-73-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-19