ChemicalBook > CAS DataBase List > 1-(4-Aminophenyl)cyclopentanecarbonitrile
1-(4-Aminophenyl)cyclopentanecarbonitrile
- Product Name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- CAS No.
- 115279-73-7
- Chemical Name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Synonyms
- KML-54;ASISCHEM D50964;1-(4-AMINOPHENYL)CYCLOPENTANECARBONITRILE;Cyclopentanecarbonitrile, 1-(4-aminophenyl)-;1-(4-aminophenyl)-1-cyclopentanecarbonitrile;1-(4-aminophenyl)cyclopentane-1-carbonitrile;1-(4-aminophenyl)cyclopentanecarbonitrile(SALTDATA: FREE)
- CBNumber
- CB1799242
- Molecular Formula
- C12H14N2
- Formula Weight
- 186.25
- MOL File
- 115279-73-7.mol
More
Less
1-(4-Aminophenyl)cyclopentanecarbonitrile Property
- Boiling point:
- 375.0±35.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 5.05±0.10(Predicted)
More
Less
Safety
- HS Code
- 2926907090
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H341Suspected of causing genetic defects
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- A615550
- Product name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR952958
- Product name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Packaging
- 250mg
- Price
- $156
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA153769
- Product name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA153769
- Product name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H37-1-8W
- Product name
- 1-(4-Aminophenyl)cyclopentanecarbonitrile
- Purity
- 95%
- Packaging
- 250mg
- Price
- $184
- Updated
- 2021/12/16
More
Less
1-(4-Aminophenyl)cyclopentanecarbonitrile Chemical Properties,Usage,Production
Uses
1-(4-Aminophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
Synthesis
1-(4-Aminophenyl)cyclopentanecarbonitrile is synthesised using 1-(4-nitrophenyl)cyclopentanecarbonitrile as a raw material by chemical reaction. The specific synthesis steps are as follows:
General procedure: The kilogram-scale reaction was performed in a 50 L single-deckglass reactor with the following conditions: 3 m (3 kg, 6.3 mol), FeO(OH)/C (460 g, 0.63 mol, 0.1 equiv), ethanol (20 L) and 80% N2H4H2O(800 g, 12.6 mol, 2 equiv) were added to a 50 L single-deck glass reactorat N2 atmosphere, then rising up the temperature to 75 C. The reactantwas stirred at 75 C for about 5 h. After the reaction was finished, the FeO(OH)/C catalyst was filtered off and washed with dichloromethane(5 L). The solvents were removed in vacuo and dried overnight byvacuum drying oven to get off-white powder 4m (2.67 kg, 6 mol), withHPLC purity >99.5%, yield 92.5%.
1-(4-Aminophenyl)cyclopentanecarbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
1-(4-Aminophenyl)cyclopentanecarbonitrile Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +86-21-68182121
- Fax
- +86-21-68182121
- Country
- China
- ProdList
- 882
- Advantage
- 52
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7893
- Advantage
- 64
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11660
- Advantage
- 64
- Tel
- 0510-0510-83593305
- Fax
- 0086-510-83593305
- sales@huifeichem.com
- Country
- China
- ProdList
- 104
- Advantage
- 62
- Tel
- 025-66099280 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19918
- Advantage
- 55
- Tel
- sales@witofly.com
- Country
- China
- ProdList
- 2867
- Advantage
- 52
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9352
- Advantage
- 58
- Tel
- 18019252918
- Fax
- QQ:1454668768
- sale@amkchem.com
- Country
- China
- ProdList
- 15415
- Advantage
- 55
- Tel
- 025-66113011 18112977050
- cb6@aikonchem.com
- Country
- China
- ProdList
- 16687
- Advantage
- 50
- Tel
- 010-88755821 13911359480
- sophia_818@126.com
- Country
- China
- ProdList
- 278
- Advantage
- 55
- Tel
- 021-58088081 Q3382968513
- Fax
- QQ3382968513
- hailey@shsendpharm.com
- Country
- China
- ProdList
- 3139
- Advantage
- 55
- Tel
- 021-54718086
- Fax
- 021-54711707
- sales5@ruiyitech.com
- Country
- China
- ProdList
- 281
- Advantage
- 58
- Tel
- 3429815786 13301662590
- Fax
- +86-21-51619052
- sales@atkchemical.com
- Country
- China
- ProdList
- 10004
- Advantage
- 55
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 9038
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- +86-530-529 6766，+86-15666160102 15666160102
- Fax
- 0530-529 6766
- info@chuangli-chem.com
- Country
- China
- ProdList
- 876
- Advantage
- 55
- Tel
- 13913522962
- 180642609@qq.com
- Country
- China
- ProdList
- 4966
- Advantage
- 58
- Tel
- 400-8210725 18016230971
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 24971
- Advantage
- 58
- Tel
- 029-88764766; 18191268030
- Fax
- 029 88764766
- wang.yali@xatuochao.com
- Country
- China
- ProdList
- 991
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- 021-18017654 18017654809
- Fax
- 2271705492
- sales@vigorchem.cn
- Country
- China
- ProdList
- 958
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55936
- Advantage
- 58
- Tel
- 028-84641798 18782128315
- 3302391190@qq.com
- Country
- China
- ProdList
- 9861
- Advantage
- 55
- Tel
- 028-86617873 18113025300
- yukijiangli@amanbio.com
- Country
- China
- ProdList
- 107
- Advantage
- 58
- Tel
- 0512-65816829 18662214788
- Fax
- 0512-65816829
- info@rovathin.com.cn
- Country
- China
- ProdList
- 9422
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19105
- Advantage
- 58
- Tel
- +8613288715578
- sales@hbmojin.com
- Country
- China
- ProdList
- 12468
- Advantage
- 58
- Tel
- 0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25363
- Advantage
- 58
- Tel
- 13981836672
- 2560370848@qq.com
- Country
- China
- ProdList
- 2803
- Advantage
- 58
- Tel
- 0510-15312278075 15312278075
- xxl_hotmail@163.com
- Country
- China
- ProdList
- 280
- Advantage
- 58
- Tel
- 0371-63682289 15538176268
- Fax
- QQ：1875164801
- jacschem@163.com
- Country
- China
- ProdList
- 10105
- Advantage
- 58
- Tel
- 15982321820
- abby@arkpharm.com
- Country
- CHINA
- ProdList
- 3279
- Advantage
- 58
- Tel
- +86-0371-86658258 15093356674;
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29826
- Advantage
- 58
- Tel
- 13522808617
- omiget@qq.com
- Country
- China
- ProdList
- 9213
- Advantage
- 58
- Tel
- 16621358918
- Fax
- QQ:402135374
- botuopharma888@163.com
- Country
- China
- ProdList
- 9215
- Advantage
- 58
- Tel
- 0371-53736046 13393710386
- Fax
- QQ:2853979814
- 2853979814@qq.com
- Country
- China
- ProdList
- 10007
- Advantage
- 58
- Tel
- 15021598081,571034478; 15021598081
- product001@xiushipharm.com
- Country
- China
- ProdList
- 4191
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44843
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39668
- Advantage
- 58
- Tel
- 2122619822
- czbjpharma@126.com
- Country
- China
- ProdList
- 18488
- Advantage
- 58
- Tel
- 13552142508
- 766912840@qq.com
- Country
- China
- ProdList
- 210
- Advantage
- 58
- Tel
- 400-8675577 19945755304
- sales@chemany.com
- Country
- China
- ProdList
- 9935
- Advantage
- 58
- Tel
- 021-50706066 15221275939
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 29803
- Advantage
- 58
- Tel
- 18989489206
- hongxitechnology@163.com
- Country
- China
- ProdList
- 4804
- Advantage
- 58
- Tel
- 0573-85609002 18157336032
- zhejia01@163.com
- Country
- China
- ProdList
- 7859
- Advantage
- 58
- Tel
- 19821570922
- angela@labgogo.com
- Country
- China
- ProdList
- 9901
- Advantage
- 58
- Tel
- 17755122868 17755122868
- 2049639868@qq.com
- Country
- China
- ProdList
- 9807
- Advantage
- 58
More
Less
View Lastest Price from 1-(4-Aminophenyl)cyclopentanecarbonitrile manufacturers
WEIFANG OUCHEM TRADE CO.,LTD.
- Product
- 1-(4-Aminophenyl)cyclopentanecarbonitrile 115279-73-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 98% Min.
- Supply Ability
- 500kg
- Release date
- 2024-01-25
Hebei Mojin Biotechnology Co., Ltd
- Product
- ASISCHEM D50964 115279-73-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-19
Hebei Mojin Biotechnology Co., Ltd
- Product
- ASISCHEM D50964 115279-73-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-19
115279-73-7, 1-(4-Aminophenyl)cyclopentanecarbonitrileRelated Search:
1-(4-BROMOPHENYL)CYCLOBUTANECARBOXYLIC ACID
2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE
BENZENAMINE, 4-CYCLOPENTYL-
2-(4-aminophenyl)propiononitrile
1-(4-Aminophenyl)cyclopentanecarbonitrile
1-Phenyl-1-cyclopentanecarbonitrile
ASISCHEM D50965