ChemicalBook > CAS DataBase List > Thalidomide-NH-CH2-COOH
Thalidomide-NH-CH2-COOH
- Product Name
- Thalidomide-NH-CH2-COOH
- CAS No.
- 927670-97-1
- Chemical Name
- Thalidomide-NH-CH2-COOH
- Synonyms
- Thalidomide-NH-CH2-COOH;Thalidomide-4-NH-C1-COOH;6-dioxopiperidin-3-yl)-1;Pomalidomide acetic acid;3-dioxoisoindolin-4-yl)glycine;3-dioxoisoindol-4-yl]amino]acetic acid;Thalidomide-NH-CH2-COOH, 10 mM in DMSO;(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine;2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]acetic acid;Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
- CBNumber
- CB18197022
- Molecular Formula
- C15H13N3O6
- Formula Weight
- 331.28
- MOL File
- 927670-97-1.mol
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Thalidomide-NH-CH2-COOH Property
- Boiling point:
- 713.9±60.0 °C(Predicted)
- Density
- 1.637±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : 50 mg/mL (150.93 mM; Need ultrasonic)
- pka
- 3.92±0.10(Predicted)
- form
- Solid
- color
- Light yellow to green yellow
- InChI
- InChI=1S/C15H13N3O6/c19-10-5-4-9(13(22)17-10)18-14(23)7-2-1-3-8(12(7)15(18)24)16-6-11(20)21/h1-3,9,16H,4-6H2,(H,20,21)(H,17,19,22)
- InChIKey
- LRGLFYOYKPSPJQ-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
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Thalidomide-NH-CH2-COOH Chemical Properties,Usage,Production
Uses
Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937)[1].
Definition
Thalidomide-NH-CH2-COOH contains a thalidomide group, an amide, an alkylC2 chain, and a terminal carboxylic acid. This product is ready for conjugation to target proteins for PROTAC R&D. It is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. This compound also can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937).
IC 50
Cereblon
References
[1] Calla M Olson, et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170. DOI:10.1038/nchembio.2538
Thalidomide-NH-CH2-COOH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Thalidomide-NH-CH2-COOH manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- Thalidomide-NH-CH2-COOH 927670-97-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-08