Thalidomide-NH-CH2-COOH

Product Name: Thalidomide-NH-CH2-COOH
CAS No.: 927670-97-1
Chemical Name: Thalidomide-NH-CH2-COOH
Synonyms: Thalidomide-NH-CH2-COOH;Thalidomide-4-NH-C1-COOH;6-dioxopiperidin-3-yl)-1;Pomalidomide acetic acid;3-dioxoisoindolin-4-yl)glycine;3-dioxoisoindol-4-yl]amino]acetic acid;Thalidomide-NH-CH2-COOH, 10 mM in DMSO;(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine;2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]acetic acid;N-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]glycine
CBNumber: CB18197022
Molecular Formula: C15H13N3O6
Formula Weight: 331.28
MOL File: 927670-97-1.mol

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Thalidomide-NH-CH2-COOH Property

Boiling point:: 713.9±60.0 °C(Predicted)
Density: 1.637±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : 50 mg/mL (150.93 mM; Need ultrasonic)
pka: 3.92±0.10(Predicted)
form: Solid
color: Light yellow to green yellow
InChI: InChI=1S/C15H13N3O6/c19-10-5-4-9(13(22)17-10)18-14(23)7-2-1-3-8(12(7)15(18)24)16-6-11(20)21/h1-3,9,16H,4-6H2,(H,20,21)(H,17,19,22)
InChIKey: LRGLFYOYKPSPJQ-UHFFFAOYSA-N
SMILES: C(O)(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Repr. 2
STOT RE 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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Thalidomide-NH-CH2-COOH Chemical Properties,Usage,Production

Uses

Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937)[1].

Definition

Thalidomide-NH-CH2-COOH contains a thalidomide group, an amide, an alkylC2 chain, and a terminal carboxylic acid. This product is ready for conjugation to target proteins for PROTAC R&D. It is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. This compound also can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937).

IC 50

Cereblon

References

[1] Calla M Olson, et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170. DOI:10.1038/nchembio.2538

Thalidomide-NH-CH2-COOH Preparation Products And Raw materials

Raw materials

Preparation Products

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Thalidomide-NH-CH2-COOH Suppliers

China 42 United States 2 Global 44

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
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Bide Pharmatech Ltd.

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Hangzhou J&H Chemical Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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TargetMol Chemicals Inc.

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CR Corporation Limited

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Lingyuan Bebiansen Biological Technology Co., Ltd

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Shandong Territorial sea Biological Technology Co., LTD

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View Lastest Price from Thalidomide-NH-CH2-COOH manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Thalidomide-NH-CH2-COOH 927670-97-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-08

927670-97-1, Thalidomide-NH-CH2-COOHRelated Search:

[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]acetic acid

Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-

Thalidomide-NH-CH2-COOH

3-dioxoisoindol-4-yl]amino]acetic acid

3-dioxoisoindolin-4-yl)glycine

6-dioxopiperidin-3-yl)-1

(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine

inhibit,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor,Thalidomide NH CH2 COOH,ThalidomideNHCH2COOH,cereblon,Thalidomide-NH-CH-2-COOH,CRBN,Thalidomide

2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]acetic acid

Thalidomide-4-NH-C1-COOH

Thalidomide-NH-CH2-COOH, 10 mM in DMSO

Pomalidomide acetic acid

N-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]glycine

927670-97-1